Johann Laubier
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View article: Label‐Free Electrochemical Microfluidic Sensing Platform for the Detection of <i>miR‐30b</i> from Milk Samples
Label‐Free Electrochemical Microfluidic Sensing Platform for the Detection of <i>miR‐30b</i> from Milk Samples Open
Circulating microRNAs (miRNAs) in biological fluids are small non‐coding RNAs identified as promising biomarkers. They are particularly abundant in milk, a fluid easily accessible without invasive techniques. However, detection methods are…
View article: CRISPR/Cas9-editing of PRNP in Alpine goats
CRISPR/Cas9-editing of PRNP in Alpine goats Open
View article: Label-Free Electrochemical Microfluidic Sensing Platform for the Detection of Mir-30b from Milk Samples
Label-Free Electrochemical Microfluidic Sensing Platform for the Detection of Mir-30b from Milk Samples Open
View article: CRISPR/Cas9-editing of PRNP in Alpine goats.
CRISPR/Cas9-editing of PRNP in Alpine goats. Open
Misfolding of the cellular PrP (PrPc) protein causes prion disease leading to neurodegenerative disorders in numerous mammalian species including goats. Lack of PrPc induces complete resistance to prion disease. The a…
View article: Variation in the prion protein gene (PRNP) open reading frame sequence in French cervids
Variation in the prion protein gene (PRNP) open reading frame sequence in French cervids Open
View article: MiRNome variations in milk fractions during feed restrictions of different intensities in dairy cows
MiRNome variations in milk fractions during feed restrictions of different intensities in dairy cows Open
Background In dairy cows, diet is one factor that can affect their milk production and composition. However, the effect of feed restriction on milk miRNome has not yet been described. Indeed, milk is the body fluid with the highest RNA con…
View article: Specific Milk Composition of miR-30b Transgenic Mice Associated with Early Duodenum Maturation in Offspring with Lasting Consequences for Growth
Specific Milk Composition of miR-30b Transgenic Mice Associated with Early Duodenum Maturation in Offspring with Lasting Consequences for Growth Open
View article: DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation
DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation Open
Mastitis is among the main reasons women cease breastfeeding, which leads to them supplementing breast milk with artificial formula. In farm animals, mastitis results in significant economic losses and the premature culling of some animals…
View article: DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part II – the impact of lactation rank
DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part II – the impact of lactation rank Open
Mastitis is among the main reasons women cease breastfeeding. In farm animals, mastitis results in significant economic losses and the premature culling of some animals. Nevertheless, the effect of inflammation on the mammary gland is not …
View article: DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part II – the impact of lactation rank
DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part II – the impact of lactation rank Open
Mastitis is among the main reasons women cease breastfeeding. In farm animals, mastitis results in significant economic losses and the premature culling of some animals. Nevertheless, the effect of inflammation on the mammary gland is not …
View article: DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation
DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation Open
Mastitis is among the main reasons women cease breastfeeding, which leads to them supplementing breast milk with artificial formula. In farm animals, mastitis results in significant economic losses and the premature culling of some animals…
View article: Characterization of the effects of a SOCS2 point mutation on mammary gland development and function
Characterization of the effects of a SOCS2 point mutation on mammary gland development and function Open
View article: Genomic DNA PCR Analysis to Assess Xenograft Development in Mouse Mammary Gland
Genomic DNA PCR Analysis to Assess Xenograft Development in Mouse Mammary Gland Open
The mouse transplantation model remains the most relevant methodology to assess the functional capacities of mammary cells and is particularly appropriate for investigations regarding mammary stem cells, whatever the species studied. Follo…
View article: Characterization of Holstein and Normande whole milk miRNomes highlights breed specificities
Characterization of Holstein and Normande whole milk miRNomes highlights breed specificities Open
View article: Influence of genetic background to the bovine milk microRNA composition
Influence of genetic background to the bovine milk microRNA composition Open
View article: Puberty is a critical window for the impact of diet on mammary gland development in the rabbit
Puberty is a critical window for the impact of diet on mammary gland development in the rabbit Open
Background Nutritional changes can affect future lactation efficiency. In a rabbit model, an obesogenic diet initiated before puberty and pursued throughout pregnancy enhances mammary differentiation, but when started during the neonatal p…
View article: Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression
Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression Open
During lactation, mammary epithelial cells secrete fat in the form of milk fat globules that originate from intracellular lipid droplets. These droplets may form de novo from the endoplasmic reticulum or be derived from existing lipid drop…
View article: Milk microRNA composition depends on dairy cow breed
Milk microRNA composition depends on dairy cow breed Open
View article: Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland
Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland Open
Oil supplementation in dairy cattle diets is used to modulate milk fat composition, as well as the expression of mammary lipogenic genes, whose regulation remains unclear. MiRNAs are small non-coding RNA considered as crucial regulators of…
View article: Influence des races bovines sur la composition en microARN du lait
Influence des races bovines sur la composition en microARN du lait Open
National audience
View article: Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy
Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy Open
R-spondin1 (Rspo1) is a member of a secreted protein family which has pleiotropic functions in development and stem cell growth. Rspo1 knock-out mice are sex-reversed, but some remain sub-fertile, so they fail to nurse their pups. A lack o…
View article: No effect of an elevated miR-30b level in mouse milk on its level in pup tissues
No effect of an elevated miR-30b level in mouse milk on its level in pup tissues Open
Recent reports have shown that ingested microRNAs may be transferred to blood, accumulate in tissues and exert canonical regulation on endogenous transcripts. In spite of several attempts to replicate these findings, they have not been con…
View article: No effect of an elevated miR-30b level in mouse milk on its level in pup tissues
No effect of an elevated miR-30b level in mouse milk on its level in pup tissues Open
Recent reports have shown that ingested microRNAs may be transferred to blood, accumulate in tissues and exert canonical regulation on endogenous transcripts. In spite of several attempts to replicate these findings, they have not been con…
View article: No effect of an elevated miR-30b level in mouse milk on its level in pup tissues.
No effect of an elevated miR-30b level in mouse milk on its level in pup tissues. Open
Recent reports have shown that ingested microRNAs may be transferred to blood, accumulate in tissues and exert canonical regulation on endogenous transcripts. In spite of several attempts to replicate these findings, they have not been con…
View article: No effect of an elevated miR-30b level in mouse milk on its level in pup tissues
No effect of an elevated miR-30b level in mouse milk on its level in pup tissues Open
Recent reports have shown that ingested microRNAs may be transferred to blood, accumulate in tissues and exert canonical regulation on endogenous transcripts. In spite of several attempts to replicate these findings, they have not been con…
View article: No effect of an elevated miR-30b level in mouse milk on its level in pup tissues
No effect of an elevated miR-30b level in mouse milk on its level in pup tissues Open
Recent reports have shown that ingested microRNAs may be transferred to blood, accumulate in tissues and exert canonical regulation on endogenous transcripts. In spite of several attempts to replicate these findings, they have not been con…
View article: No effect of an elevated miR-30b level in mouse milk on its level in pup tissues
No effect of an elevated miR-30b level in mouse milk on its level in pup tissues Open
Recent reports have shown that ingested microRNAs may be transferred to blood, accumulate in tissues and exert canonical regulation on endogenous transcripts. In spite of several attempts to replicate these findings, they have not been con…