Johanna M. Ospel
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View article: Influence of recent randomized MeVO trials on current practice patterns and future role of MeVO thrombectomy
Influence of recent randomized MeVO trials on current practice patterns and future role of MeVO thrombectomy Open
Introduction Numerous non-randomized studies suggest the benefit of endovascular thrombectomy (EVT) for medium vessel occlusion (MeVO) stroke, while recent randomized trials showed no benefit. In clinical practice, MeVO management remains …
View article: Association of Minimal Clinically Important Difference With Infarct Volume in Clinical Poststroke Outcomes
Association of Minimal Clinically Important Difference With Infarct Volume in Clinical Poststroke Outcomes Open
Background Infarct volume is an imaging biomarker of ischemic tissue injury strongly correlated with poststroke outcomes and reperfusion benefit. We aimed to evaluate the follow‐up infarct volume (FIV) difference corresponding to a 1%, 5%,…
View article: Decision-Making for Endovascular Thrombectomy in Patients With Large Vessel Occlusions and Mild Neurological Deficit: A Consensus Statement
Decision-Making for Endovascular Thrombectomy in Patients With Large Vessel Occlusions and Mild Neurological Deficit: A Consensus Statement Open
Acute ischemic stroke patients with mild deficits (National Institutes of Health Stroke Scale [NIHSS] of 0–5) but confirmed large vessel occlusions (LVO) present a clinical challenge for endovascular thrombectomy (EVT) decisions due to lim…
View article: Literature review and DELPHI consensus on follow-up and retreatment of intracranial aneurysms with intrasaccular devices
Literature review and DELPHI consensus on follow-up and retreatment of intracranial aneurysms with intrasaccular devices Open
Background Intracranial aneurysms are increasingly detected incidentally due to broader use of neuroimaging. Intrasaccular devices are frequently used to prevent rupture, yet standardized follow-up and retreatment strategies remain undefin…
View article: Health Economic Impact of Incomplete Reperfusion Patterns After Endovascular Thrombectomy in Acute Ischemic Stroke
Health Economic Impact of Incomplete Reperfusion Patterns After Endovascular Thrombectomy in Acute Ischemic Stroke Open
Background and Purpose Incomplete reperfusion in endovascular thrombectomy (EVT) impacts patients’ outcomes. Different incomplete reperfusion patterns may benefit from targeted therapeutic strategies, e.g. EVT-accessible incomplete reperfu…
View article: Automated ischemic stroke lesion detection on non-contrast brain CT: a large-scale clinical feasibility test AI stroke lesion detection on NCCT
Automated ischemic stroke lesion detection on non-contrast brain CT: a large-scale clinical feasibility test AI stroke lesion detection on NCCT Open
Background Non-contrast CT (NCCT) is widely used imaging modality for acute stroke imaging but often fails to detect subtle early ischemic changes. Such underestimation can lead clinicians to overlook tissue-level information. This study a…
View article: Automated Ischemic Stroke Lesion Detection On Non-Contrast Brain CT: A Large-Scale Clinical Feasibility Test
Automated Ischemic Stroke Lesion Detection On Non-Contrast Brain CT: A Large-Scale Clinical Feasibility Test Open
Background Non-contrast CT (NCCT) is widely used imaging modality for acute stroke imaging but often fails to detect subtle early ischemic changes. Such underestimation can lead clinicians to overlook tissue-level information. This study a…
View article: Detection of Medium Vessel Occlusions (MeVOs) using Velocity-Encoded Vessel Maps in Selection and Endovascular Treatment of Double MeVO – A Case Report
Detection of Medium Vessel Occlusions (MeVOs) using Velocity-Encoded Vessel Maps in Selection and Endovascular Treatment of Double MeVO – A Case Report Open
View article: E.4 Safety and outcomes of middle meningeal artery embolization for pseudoaneurysms and aneurysms: a systematic review
E.4 Safety and outcomes of middle meningeal artery embolization for pseudoaneurysms and aneurysms: a systematic review Open
Background: Middle meningeal artery embolization (MMAE) is increasingly used to treat chronic subdural hematomas, arteriovenous fistulas and meningiomas. Less commonly, MMAE is performed for pseudoaneurysms and aneurysms. While procedural …
View article: Combining Computed Tomography Perfusion and Baseline National Institutes of Health Stroke Scale to Assess the Clinical Penumbra in Ischemic Stroke
Combining Computed Tomography Perfusion and Baseline National Institutes of Health Stroke Scale to Assess the Clinical Penumbra in Ischemic Stroke Open
View article: Comparing Early National Institutes of Health Stroke Scale Versus 90‐Day Modified Rankin Scale Outcomes in Acute Ischemic Stroke Trials: A Systematic Review and Analysis
Comparing Early National Institutes of Health Stroke Scale Versus 90‐Day Modified Rankin Scale Outcomes in Acute Ischemic Stroke Trials: A Systematic Review and Analysis Open
Background Early National Institutes of Health Stroke Scale (NIHSS) assessment may provide practical benefits over 90‐day modified Rankin Scale (mRS), but it is unclear how it compares in adjudicating randomized clinical trial (RCT) result…
View article: Perfusion-derived metrics to calculate cerebral infarct growth rate, “ultrafast progressor” phenotype, and neuroprotection
Perfusion-derived metrics to calculate cerebral infarct growth rate, “ultrafast progressor” phenotype, and neuroprotection Open
Cerebral infarct growth rate (IGR) varies widely in ischemic stroke, and this has important clinical implications. In their recent article, Lin et al. explored IGR characteristics and treatment modification in so-called “ultrafast progress…
View article: Spot Sign in Intracerebral Hemorrhage: Critical Reappraisal and Future Clinical Implications
Spot Sign in Intracerebral Hemorrhage: Critical Reappraisal and Future Clinical Implications Open
Hematoma expansion (HE) is a common occurrence affecting around 10% to 30% of patients with acute intracerebral hemorrhage within the initial hours from symptom onset and is the only modifiable factor associated with poor clinical outcomes…
View article: Stepwise improvement in intracerebral haematoma expansion prediction with advanced imaging: a comprehensive comparison of existing scores
Stepwise improvement in intracerebral haematoma expansion prediction with advanced imaging: a comprehensive comparison of existing scores Open
Background We aim to comprehensively assess and compare the predictive performance of haematoma expansion (HE) scores in a homogeneous cohort of acute intracerebral haemorrhage (ICH) patients. Methods Existing scores for predicting HE in a…
View article: Initial intraventricular involvement and early intracerebral hematoma retraction: The “ventricular washout”
Initial intraventricular involvement and early intracerebral hematoma retraction: The “ventricular washout” Open
Introduction: Intraventricular hematoma (IVH) occurs in approximately 40% of acute intracerebral hemorrhage (ICH) patients and is significantly associated with worse clinical outcomes. According to cerebrospinal fluid dynamics, some blood …
View article: Improvements in endovascular stroke treatment workflow over 5 years: ESCAPE to ESCAPE-NA1
Improvements in endovascular stroke treatment workflow over 5 years: ESCAPE to ESCAPE-NA1 Open
Background and Purpose Rapid treatment is a major determinant of outcome in acute ischemic stroke patients with large vessel occlusion. We used patient-level data from the ESCAPE and ESCAPE-NA1 trials to evaluate whether and to what extent…
View article: A visual journey through medium vessel occlusion strokes: From diagnosis to treatment
A visual journey through medium vessel occlusion strokes: From diagnosis to treatment Open
Acute ischemic stroke occurs when a blood clot obstructs cerebral blood flow, leading to ischemia and potentially irreversible brain damage. While large vessel occlusions are known for their catastrophic effects, medium vessel occlusions (…
View article: Modified Rankin Scale at 90 Days Versus National Institutes of Health Stroke Scale at 24 Hours as Primary Outcome in Acute Stroke Trials
Modified Rankin Scale at 90 Days Versus National Institutes of Health Stroke Scale at 24 Hours as Primary Outcome in Acute Stroke Trials Open
Background We investigate whether the National Institutes of Health Stroke Scale (NIHSS) at 24 hours could serve as a primary outcome in acute ischemic stroke trials, and whether combining 90‐day modified Rankin Scale (mRS) and 24‐hour NIH…
View article: Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial
Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial Open
View article: Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial
Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial Open
Background and Purpose In the ESCAPE-NA1 (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischaemic Stroke) trial, treatment with nerinetide was associated with improved outcomes in patients who did not receive intravenous alt…
View article: Prevalence of ipsilateral “vulnerable carotid plaques with <50 % stenosis” on CT angiography in embolic stroke of undetermined source
Prevalence of ipsilateral “vulnerable carotid plaques with <50 % stenosis” on CT angiography in embolic stroke of undetermined source Open
In ESUS patients undergoing thrombectomy for anterior circulation large vessel occlusion, vulnerable carotid plaques are more prevalent ipsilateral to the intracranial occlusion. Irregular plaque surface, and a higher degree of stenosis we…
View article: Sex differences in brain MRI using deep learning toward fairer healthcare outcomes
Sex differences in brain MRI using deep learning toward fairer healthcare outcomes Open
This study leverages deep learning to analyze sex differences in brain MRI data, aiming to further advance fairness in medical imaging. We employed 3D T1-weighted Magnetic Resonance images from four diverse datasets: Calgary-Campinas-359, …
View article: Effects of reperfusion grade and reperfusion strategy on the clinical outcome: Insights from ESCAPE-NA1 trial
Effects of reperfusion grade and reperfusion strategy on the clinical outcome: Insights from ESCAPE-NA1 trial Open
Background We evaluated the association of reperfusion quality and different patterns of achieved reperfusion with clinical and radiological outcomes in the ESCAPE NA1 trial. Methods Data are from the ESCAPE-NA1 trial. Good clinical outcom…
View article: Contrast-Induced Encephalopathy: A Case Series Analysis
Contrast-Induced Encephalopathy: A Case Series Analysis Open
Background: Contrast-induced encephalopathy (CIE) is a rare adverse event linked to intravascular use of iodine-containing contrast media. The prevalence of CIE could increase in the future due to growing numbers of endovascular procedures…
View article: European Stroke Organisation (ESO) and European Society for Minimally Invasive Neurological Therapy (ESMINT) guideline on acute management of basilar artery occlusion
European Stroke Organisation (ESO) and European Society for Minimally Invasive Neurological Therapy (ESMINT) guideline on acute management of basilar artery occlusion Open
The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on the acute management of patients with basilar artery occlusion (BAO). These guidelines were prepared following the Standard…
View article: Endovascular treatment to improve outcomes for medium vessel occlusions: The ESCAPE-MeVO trial
Endovascular treatment to improve outcomes for medium vessel occlusions: The ESCAPE-MeVO trial Open
Rationale: Clinical outcomes in acute ischemic stroke due to medium vessel occlusion (MeVO) are often poor when treated with best medical management. Data from non-randomized studies suggest that endovascular treatment (EVT) may improve ou…
View article: Infarcts Due to Large Vessel Occlusions Continue to Grow Despite Near-Complete Reperfusion After Endovascular Treatment
Infarcts Due to Large Vessel Occlusions Continue to Grow Despite Near-Complete Reperfusion After Endovascular Treatment Open
Background and Purpose Infarcts in acute ischemic stroke (AIS) patients may continue to grow even after reperfusion, due to mechanisms such as microvascular obstruction and reperfusion injury. We investigated whether and how much infarcts …
View article: How Do Quantitative Tissue Imaging Outcomes in Acute Ischemic Stroke Relate to Clinical Outcomes?
How Do Quantitative Tissue Imaging Outcomes in Acute Ischemic Stroke Relate to Clinical Outcomes? Open
Background and Purpose Infarct volume and other imaging markers are increasingly used as surrogate measures for clinical outcome in acute ischemic stroke research, but how improvements in these imaging surrogates translate into better clin…
View article: P.029 Endovascular therapy for cerebral venous thrombosis: an international survey
P.029 Endovascular therapy for cerebral venous thrombosis: an international survey Open
Background: Cerebral venous thrombosis (CVT) is a rare cause of stroke, with 10–15% of patients experiencing dependence or death. The role of endovascular therapy (EVT) in the management of CVT remains controversial and practice patterns a…
View article: European Stroke Organisation and European Society for Minimally Invasive Neurological Therapy guideline on acute management of basilar artery occlusion
European Stroke Organisation and European Society for Minimally Invasive Neurological Therapy guideline on acute management of basilar artery occlusion Open
The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on the acute management of patients with basilar artery occlusion (BAO). These guidelines were prepared following the Standard…