Johanna Viiri
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View article: Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice
Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice Open
Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness worldwide in the elderly population. In our previous studies, we found that deficiencies in the nuclear factor, erythroid 2 like 2 (NFE2L2) and per…
View article: [Retracted] Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice
[Retracted] Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice Open
Chronic oxidative stress eventually leads to protein aggregation in combination with impaired autophagy, which has been observed in age‐related macular degeneration. We have previously shown an effective age‐related macular degeneration di…
View article: Proteostasis in retinal pigment epithelial cells: Relevance to age-related macular degeneration
Proteostasis in retinal pigment epithelial cells: Relevance to age-related macular degeneration Open
View article: Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model
Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model Open
Increased oxidative stress and mitochondrial damage are observed in protein aggregation diseases, such as age-related macular degeneration (AMD). We have recently reported elevated levels of oxidative stress markers, damaged mitochondria, …
View article: Seeing is believing: live imaging of microvascular pathology in glaucoma
Seeing is believing: live imaging of microvascular pathology in glaucoma Open
50 to 75.97.3% of ophthalmologists are satisfied/very satisfied to prescribe the PF-MD DTFC.81.7% of patients are satisfied enough to continue with the PF-MD device.Conclusions: The results confirm the interest of both ophthalmologists and…
View article: Triple procedure for treating advanced AAK with cataract
Triple procedure for treating advanced AAK with cataract Open
50 to 75.97.3% of ophthalmologists are satisfied/very satisfied to prescribe the PF-MD DTFC.81.7% of patients are satisfied enough to continue with the PF-MD device.Conclusions: The results confirm the interest of both ophthalmologists and…
View article: Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration Open
View article: NRF-2/PGC-1α deficiency induces retinal degeneration in mice
NRF-2/PGC-1α deficiency induces retinal degeneration in mice Open
View article: Mitochondrial quality control in AMD: does mitophagy play a pivotal role?
Mitochondrial quality control in AMD: does mitophagy play a pivotal role? Open
View article: Stillbene compounds induce dynamic autophagy and decrease protein aggregation during proteasome inhibition
Stillbene compounds induce dynamic autophagy and decrease protein aggregation during proteasome inhibition Open
View article: The Nrf2 and PGC-1α deficient murine retina reveals retinal pigment epithelium damage that coincides with autophagy decline and damaged mitochondria.
The Nrf2 and PGC-1α deficient murine retina reveals retinal pigment epithelium damage that coincides with autophagy decline and damaged mitochondria. Open
View article: Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells
Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Open
The impairment of autophagic and proteasomal cleansing together with changes in pigmentation has been documented in retinal pigment epithelial (RPE) cell degeneration. However, the function and co-operation of these mechanisms in melanosom…
View article: Autophagy machinery is functional in human pluripotent stem cell-derived retinal pigment epithelial cells
Autophagy machinery is functional in human pluripotent stem cell-derived retinal pigment epithelial cells Open
View article: Cytoplasmic SQSTM1/p62, ubiquitin and ELAVL1/HuR proteins in foveomacular, perimacular and peripheral RPE cells.
Cytoplasmic SQSTM1/p62, ubiquitin and ELAVL1/HuR proteins in foveomacular, perimacular and peripheral RPE cells. Open
Cytoplasmic SQSTM1/p62, ubiquitin and ELAVL1/HuR proteins in foveomacular, perimacular and peripheral RPE cells.