Johannes Breitling
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View article: A versatile look‐up algorithm for mapping pH values and magnesium ion content using <sup>31</sup>P MRSI
A versatile look‐up algorithm for mapping pH values and magnesium ion content using <sup>31</sup>P MRSI Open
31 P MRSI allows for the non‐invasive mapping of pH and magnesium ion content (Mg) in vivo, by translating the chemical shifts of inorganic phosphate and adenosine‐5′‐triphosphate (ATP) to pH and Mg via suitable calibration equations, such…
View article: Whole-Brain Intracellular pH Mapping of Gliomas Using High-Resolution <sup>31</sup>P MR Spectroscopic Imaging at 7.0 T
Whole-Brain Intracellular pH Mapping of Gliomas Using High-Resolution <sup>31</sup>P MR Spectroscopic Imaging at 7.0 T Open
Malignant tumors commonly exhibit a reversed pH gradient compared with normal tissue, with a more acidic extracellular pH and an alkaline intracellular pH (pHi). In this prospective study, pHi values in gliomas were q…
View article: Semi‐solid <scp>MT</scp> and <scp>APTw CEST‐MRI</scp> predict clinical outcome of patients with glioma early after radiotherapy
Semi‐solid <span>MT</span> and <span>APTw CEST‐MRI</span> predict clinical outcome of patients with glioma early after radiotherapy Open
Purpose The purpose of this study was to compare the potential of asymmetry‐based (APTw asym ), Lorentzian‐fit‐based (PeakAreaAPT and MT const ), and relaxation‐compensated (MTR Rex APT and MTR Rex MT) CEST contrasts of the amide proton tr…
View article: <scp><sup>31</sup>P MRSI</scp>at 7 T enables high‐resolution volumetric mapping of the intracellular magnesium ion content in human lower leg muscles
<span><sup>31</sup>P MRSI</span>at 7 T enables high‐resolution volumetric mapping of the intracellular magnesium ion content in human lower leg muscles Open
Purpose The non‐invasive determination of the free magnesium ion concentration ([Mg 2+ free ]) using 31 P MRSI in vivo is of interest in research on various pathologies, e.g. diabetes. The purpose of this study was to demonstrate the poten…
View article: Motion correction for three‐dimensional chemical exchange saturation transfer imaging without direct water saturation artifacts
Motion correction for three‐dimensional chemical exchange saturation transfer imaging without direct water saturation artifacts Open
In chemical exchange saturation transfer (CEST) MRI, motion correction is compromised by the drastically changing image contrast at different frequency offsets, particularly at the direct water saturation. In this study, a simple extension…
View article: Mapping intracellular pH in tumors using amide and guanidyl CEST‐MRI at 9.4 T
Mapping intracellular pH in tumors using amide and guanidyl CEST‐MRI at 9.4 T Open
Purpose In principle, non‐invasive mapping of the intracellular pH (pH i ) in vivo is possible using endogenous chemical exchange saturation transfer (CEST)‐MRI of the amide and guanidyl signals. However, the application for cancer imaging…
View article: Mapping an Extended Metabolic Profile of Gliomas Using High-Resolution 31P MRSI at 7T
Mapping an Extended Metabolic Profile of Gliomas Using High-Resolution 31P MRSI at 7T Open
Phosphorus magnetic resonance spectroscopic imaging ( 31 P MRSI) is of particular interest for investigations of patients with brain tumors as it enables to non-invasively assess altered energy and phospholipid metabolism in vivo . However…
View article: Clinical routine acquisition protocol for 3D relaxation‐compensated APT and rNOE CEST‐MRI of the human brain at 3T
Clinical routine acquisition protocol for 3D relaxation‐compensated APT and rNOE CEST‐MRI of the human brain at 3T Open
Purpose The value of relaxation‐compensated amide proton transfer (APT) and relayed nuclear Overhauser effect (rNOE) chemical exchange saturation transfer (CEST)‐MRI has already been demonstrated in various neuro‐oncological clinical appli…
View article: Volumetric mapping of intra‐ and extracellular pH in the human brain using <sup>31</sup>P MRSI at 7T
Volumetric mapping of intra‐ and extracellular pH in the human brain using <sup>31</sup>P MRSI at 7T Open
Purpose In vivo 31 P MRSI enables noninvasive mapping of absolute pH values via the pH‐dependent chemical shifts of inorganic phosphates (P i ). A particular challenge is the quantification of extracellular P i with low SNR in vivo. The pu…
View article: Optimized dualCEST‐MRI for imaging of endogenous bulk mobile proteins in the human brain
Optimized dualCEST‐MRI for imaging of endogenous bulk mobile proteins in the human brain Open
Dual‐frequency irradiation chemical exchange saturation transfer (dualCEST) allows imaging of endogenous bulk mobile proteins by selectively measuring the intramolecular spin diffusion. The resulting specificity to changes in the concentra…
View article: Dynamic glucose‐enhanced (DGE) MRI in the human brain at 7 T with reduced motion‐induced artifacts based on quantitative R<sub>1ρ</sub> mapping
Dynamic glucose‐enhanced (DGE) MRI in the human brain at 7 T with reduced motion‐induced artifacts based on quantitative R<sub>1ρ</sub> mapping Open
Purpose Dynamic glucose‐enhanced (DGE)‐MRI based on chemical exchange‐sensitive MRI, that is, glucoCEST and gluco‐chemical exchange‐sensitive spin‐lock (glucoCESL), is intrinsically prone to motion‐induced artifacts because the final DGE c…
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View article: A novel normalization for amide proton transfer CEST MRI to correct for fat signal–induced artifacts: application to human breast cancer imaging
A novel normalization for amide proton transfer CEST MRI to correct for fat signal–induced artifacts: application to human breast cancer imaging Open
Purpose The application of amide proton transfer (APT) CEST MRI for diagnosis of breast cancer is of emerging interest. However, APT imaging in the human breast is affected by the ubiquitous fat signal preventing a straightforward applicat…
View article: FullHD CEST Bildgebung des Gehirns bei 7T
FullHD CEST Bildgebung des Gehirns bei 7T Open
Einleitung: Spektral hochaufgelöste in vivo Z-Spektren können zu einer besseren Identifizierung von CEST Substrukturen, aber auch für quantitative CEST Evaluierungen oder Machine-Learning Ansätze genutzt werden. Die zusätzlich benötigte Me…
View article: Dual‐frequency irradiation CEST‐MRI of endogenous bulk mobile proteins
Dual‐frequency irradiation CEST‐MRI of endogenous bulk mobile proteins Open
A novel MRI contrast is proposed which enables the selective detection of endogenous bulk mobile proteins in vivo . Such a non‐invasive imaging technique may be of particular interest for many diseases associated with pathological alterati…