Johannes Kreuzer
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View article: Supplementary Figures S1-S9 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Figures S1-S9 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Supplementary Figures associated with each Main Figure
View article: Supplementary Table S6 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S6 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Excel file containing all data corresponding to Figure 5
View article: Supplementary Table S4 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S4 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Excel file containing all data corresponding to Figure 3
View article: Supplementary Table S3 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S3 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Excel file containing all data corresponding to Figure 2
View article: Supplementary Table S9 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S9 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Excel file summarizing top dependencies, groupings and molecular features associated with BTC.
View article: Supplementary Table S1 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S1 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Excel file containing primary datasets used in this study
View article: Data from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Data from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Biliary tract cancers (BTC) are aggressive malignancies encompassing intrahepatic and extrahepatic cholangiocarcinoma, gallbladder carcinoma, and ampullary carcinoma. Here, we report integrative analysis of 63 BTC cell lines via multi-omic…
View article: Supplementary Table S8 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S8 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Excel file containing all data corresponding to Figure 7
View article: Supplementary Table S7 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S7 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Excel file containing all data corresponding to Figure 6
View article: Supplementary Table S2 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S2 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Excel file containing all data corresponding to Figure 1
View article: Supplementary Table S5 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S5 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
Excel file containing all data corresponding to Figure 4
View article: Supplementary Table S10 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
Supplementary Table S10 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets Open
List of resources and reagents used in this study
View article: Author response: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics
Author response: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics Open
View article: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics
Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics Open
Oocyte meiotic divisions represent a critical process in sexual reproduction, as a diploid non-dividing oocyte is transformed into a haploid fertilizable egg, as a prelude for the subsequent embryonic divisions and differentiation. Althoug…
View article: CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors
CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors Open
The mitotic inhibitor docetaxel (DTX) is often used to treat endocrine-refractory metastatic breast cancer, but initial responses are mitigated as patients develop disease progression. Using a cohort of ex vivo cultured circulating tumor c…
View article: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics
Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics Open
Oocyte meiotic divisions represent a critical process in sexual reproduction, as a diploid non-dividing oocyte is transformed into a haploid fertilizable egg, as a prelude for the subsequent embryonic divisions and differentiation. Althoug…
View article: Author response: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics
Author response: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics Open
View article: LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers Open
The efficacy of molecularly targeted therapies may be limited by co-occurring mutations within a tumor. Conversely, these alterations may confer collateral vulnerabilities that can be therapeutically leveraged. KRAS -mutant lung cancers ar…
View article: Loss of P. falciparum Amino Acid Transporter (ApiAT2) Increases Intracellular Proline and Confers Resistance to Prolyl-tRNA Synthetase Inhibitors
Loss of P. falciparum Amino Acid Transporter (ApiAT2) Increases Intracellular Proline and Confers Resistance to Prolyl-tRNA Synthetase Inhibitors Open
View article: Author response: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics
Author response: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics Open
View article: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics
Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics Open
Oocyte meiotic divisions represent a critical process in sexual reproduction, as a diploid non-dividing oocyte is transformed into a haploid fertilizable egg, as a prelude for the subsequent embryonic divisions and differentiation. Althoug…
View article: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics
Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics Open
Oocyte meiotic divisions represent a critical process in sexual reproduction, as a diploid non-dividing oocyte is transformed into a haploid fertilizable egg, as a prelude for the subsequent embryonic divisions and differentiation. Althoug…
View article: Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics
Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics Open
Oocyte meiotic divisions represent a critical process in sexual reproduction, as a diploid non-dividing oocyte is transformed into a haploid fertilizable egg, as a prelude for the subsequent embryonic divisions and differentiation. Althoug…
View article: Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets Open
Biliary tract cancers (BTCs) are a group of deadly malignancies encompassing intrahepatic and extrahepatic cholangiocarcinoma, gallbladder carcinoma, and ampullary carcinoma. Here, we present the integrative analysis of 63 BTC cell lines v…
View article: FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma
FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma Open
Genomic alterations that activate Fibroblast Growth Factor Receptor 2 (FGFR2) are common in intrahepatic cholangiocarcinoma (ICC) and confer sensitivity to FGFR inhibition. However, the depth and duration of response is often limited. Here…
View article: FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma
FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma Open
Genomic alterations that activate Fibroblast Growth Factor Receptor 2 (FGFR2) are common in intrahepatic cholangiocarcinoma (ICC) and confer sensitivity to FGFR inhibition. However, the depth and duration of response is often limited. Here…
View article: APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease
APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease Open
View article: <i>CDKN1B</i>(p27<sup>kip1</sup>) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors
<i>CDKN1B</i>(p27<sup>kip1</sup>) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors Open
The mitotic inhibitor docetaxel (DTX) is often used to treat endocrine-refractory metastatic breast cancer, but initial responses are mitigated as patients eventually have disease progression. Using a cohort of ex vivo cultures of circulat…
View article: Genetic retargeting of E3 ligases to enhance CAR T cell therapy
Genetic retargeting of E3 ligases to enhance CAR T cell therapy Open
View article: Regulation of RNA methylation by therapy treatment, promotes tumor survival
Regulation of RNA methylation by therapy treatment, promotes tumor survival Open
Our data previously revealed that chemosurviving cancer cells translate specific genes. Here, we find that the m6A-RNA-methyltransferase, METTL3, increases transiently in chemotherapy-treated breast cancer and leukemic cells in vitro and i…