Johannes M.I.H. Gho
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View article: MRI of the ‘Tiger’: a case series
MRI of the ‘Tiger’: a case series Open
Background Sawtooth cardiomyopathy (CMP) or ‘Tiger heart’ is a rare form of CMP of which only several cases have been described in literature. Hereby, we present two cases with this phenotype using cardiovascular magnetic resonance (CMR). …
View article: Multimodality Imaging of Cardiac Paragangliomas
Multimodality Imaging of Cardiac Paragangliomas Open
Paragangliomas are rare neuroendocrine tumors of extra-adrenal autonomic paraganglia origin. Paragangliomas rarely involve the heart, and they account for less than 1% of primary cardiac tumors. Most cardiac paragangliomas are incidentally…
View article: Transcriptional regulation profiling reveals PPARA-mediated fatty acid oxidation as a novel therapeutic target in phospholamban R14del cardiomyopathy
Transcriptional regulation profiling reveals PPARA-mediated fatty acid oxidation as a novel therapeutic target in phospholamban R14del cardiomyopathy Open
Carriers of the R14del pathogenic variant in the phospholamban ( PLN ) gene develop severe cardiomyopathy with extracellular adipocyte infiltration and intracellular cardiomyocyte mitochondrial disturbances. However, the basis of this meta…
View article: Transcriptional regulation profiling reveals disrupted lipid metabolism in failing hearts with a pathogenic phospholamban mutation
Transcriptional regulation profiling reveals disrupted lipid metabolism in failing hearts with a pathogenic phospholamban mutation Open
Background The R14del mutation in the phospholamban ( PLN ) gene is associated with various types of cardiomyopathies and increases the risk of developing life-threatening ventricular arrhythmias. In this study, we focused on a homogeneous…
View article: Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci
Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci Open
Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in …
View article: An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors
An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors Open
Objectives To investigate the incidence and determinants of heart failure (HF) following a myocardial infarction (MI) in a contemporary cohort of patients with MI using routinely collected primary and hospital care electronic health record…
View article: Heart failure following STEMI: a contemporary cohort study of incidence and prognostic factors
Heart failure following STEMI: a contemporary cohort study of incidence and prognostic factors Open
Objective The aim of the current study was to determine the contemporary incidence, risk factors and prognosis of heart failure (HF) after ST-elevation myocardial infarction (STEMI). Methods We used the Arrhythmia Genetics in the Netherlan…
View article: Additional file 1: Table S2. of Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype
Additional file 1: Table S2. of Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype Open
Supplementary file. Supporting information and analyses results. (XLSX 45Â kb)
View article: Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population‐based linked electronic health record cohort study in 2.1 million people
Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population‐based linked electronic health record cohort study in 2.1 million people Open
Aims The prognosis of patients hospitalized for worsening heart failure ( HF ) is well described, but not that of patients managed solely in non‐acute settings such as primary care or secondary outpatient care. We assessed the distribution…