Johannes Piepgras
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View article: Glial Fibrillary Acid Protein Reflects Disease Activity in Autoimmune Encephalitis
Glial Fibrillary Acid Protein Reflects Disease Activity in Autoimmune Encephalitis Open
Background and Purpose Management of autoimmune encephalitis (AE) is challenging due to a lack of reliable biomarkers. We here assess the combination of glial fibrillary acid protein (GFAP) and neurofilament (NfL) as biomarkers for diagnos…
View article: Atypical adverse events in a real-world study of long-term immunomodulation for multiple sclerosis and neuromyelitis optica spectrum disorder
Atypical adverse events in a real-world study of long-term immunomodulation for multiple sclerosis and neuromyelitis optica spectrum disorder Open
Background: Immunotherapies are integral in managing multiple sclerosis (MS) and related demyelinating diseases, but adverse drug reactions significantly affect the tolerability of disease-modifying therapies (DMTs). Objectives: This study…
View article: A tale of two viruses: A bipolar disorder patient's path to Varicella Zoster Meningoencephalitis diagnosis in the pandemic era
A tale of two viruses: A bipolar disorder patient's path to Varicella Zoster Meningoencephalitis diagnosis in the pandemic era Open
View article: Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies
Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies Open
Together, our data provide evidence for early neuroaxonal damage and support the need for timely therapeutic interventions in GAD65 antibody-associated neurologic disorders.
View article: Enhancement of Phosphorylation and Transport Activity of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter 3 by C3bot and a 26mer C3bot Peptide
Enhancement of Phosphorylation and Transport Activity of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter 3 by C3bot and a 26mer C3bot Peptide Open
In primary murine hippocampal neurons we investigated the regulation of EAAT3-mediated glutamate transport by the Clostridium botulinum C3 transferase C3bot and a 26mer peptide derived from full length protein. Incubation with either enzym…
View article: CSF Findings in Acute NMDAR and LGI1 Antibody–Associated Autoimmune Encephalitis
CSF Findings in Acute NMDAR and LGI1 Antibody–Associated Autoimmune Encephalitis Open
NMDAR-E and LGI-E differ in their typical extent of CSF inflammation. In addition, the patterns formed by the different inflammatory CSF parameters and their relationship with disease severity, age, and disease duration are subtype-charact…
View article: Neurofilament light chain levels reflect outcome in a patient with glutamic acid decarboxylase 65 antibody–positive autoimmune encephalitis under immune checkpoint inhibitor therapy
Neurofilament light chain levels reflect outcome in a patient with glutamic acid decarboxylase 65 antibody–positive autoimmune encephalitis under immune checkpoint inhibitor therapy Open
Neurological immune‐mediated side effects are rare but often severe complications of immune checkpoint inhibitor (ICI) treatment. This report describes a severe case of nivolumab/ipilimumab‐associated glutamic acid decarboxylase 65–positiv…
View article: Der Einfluss von Clostridium botulinum C3 Proteinen auf die neuronale Glutamat-Aufnahme
Der Einfluss von Clostridium botulinum C3 Proteinen auf die neuronale Glutamat-Aufnahme Open
Einleitung: Nach Rückenmarkstraumata kann die neuronale Regeneration durch Clostridium botulinum C3 Exoenzym (C3bot) und C3bot 26mer (ein von C3bot abgeleitetes Peptid) gefördert werden. Besondere Aufmerksamkeit gilt dabei C3bot 26mer, da …
View article: Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains
Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains Open
Objective: To identify the specific domains of the presynaptic protein synapsin targeted by recently described autoantibodies to synapsin. Methods: Sera of 20 and CSF of two patients with different psychiatric and neurological disorders pr…
View article: Intrathecal immunoglobulin A and G antibodies to synapsin in a patient with limbic encephalitis
Intrathecal immunoglobulin A and G antibodies to synapsin in a patient with limbic encephalitis Open
This report identifies isoforms of the synaptic vesicle-associated protein synapsin as targets of intrathecally produced IgA and IgG antibodies in a patient with limbic encephalitis. Future studies should clarify the prevalence and pathoge…
View article: Anti-DPPX encephalitis
Anti-DPPX encephalitis Open
OBJECTIVE: To characterize pathogenic effects of antibodies to dipeptidyl-peptidase-like protein 6 (DPPX), a subunit of Kv4.2 potassium channels, on gut and brain neurons. METHODS: We identified a new patient with anti-DPPX encephalitis an…