Explanipedia

Predicting cognitive aging through brain structural covariance networks: A decade of longitudinal insights using source-based morphometry Open

Xingsong Wang, Christina J. Herold, Li Kong, Raymond C. K. Chan, Johannes Schröder · 2025

Cognitive aging presents significant challenges to public health as the global population ages. While functional connectivity changes in aging have been extensively studied, the predictive value of structural covariance networks remains un…

Structural Cerebral Correlates of Perplexity: Exploring a Linguistic Marker in Cognitive Aging Open

Xingsong Wang, Christina J. Herold, C. Frankenberg, Ayimnisagul Ablimit, Tanja Schultz , et al. · 2025

Language changes are among the earliest indicators of cognitive decline in aging. Perplexity, a linguistic measure derived from information theory that quantifies speech predictability, has emerged as a potential marker for detecting early…

Pronoun use in preclinical and early stages of Alzheimer's dementia Open

Dagmar Bittner, C. Frankenberg, Johannes Schröder · 2023

The present study aims at improving the predictive power of the use of pronouns in computational modeling of the risk of Alzheimer's dementia (AD) by (i) further determining the onset of increased pronoun use in AD and (ii) providing insig…

Perplexity and its structural cerebral correlates: A promising marker for cognitive decline? Open

Christina Herold, C. Frankenberg, Ayimunishagu Abulimiti, Tanja Schultz, Li Kong , et al. · 2023

Background Recent studies identified linguistic changes as a promising marker of early Alzheimer´s disease (AD) and mild cognitive impairment (MCI). Perplexity – i.e. a measure of content complexity and therefore predictability of speech –…

Neurological soft signs and brain morphology in people living with HIV Open

Christina J. Herold, Li Kong, María Elena Ceballos, Johannes Schröder, Pablo Toro · 2022

Neurological soft signs (NSS) are a common feature of severe psychiatric disorders such as schizophrenia but are also prevalent in organic brain diseases like HIV-associated neurocognitive disorder (HAND) or Alzheimer’s disease. While dist…

Differences in Cognitive Functioning in Two Birth Cohorts Born 20 Years Apart: Data from the Interdisciplinary Longitudinal Study of Ageing Open

Christina Degen, C. Frankenberg, Pablo Toro, Johannes Schröder · 2022

We compared neuropsychological functioning and prevalence of mild cognitive impairment (MCI) in two birth cohorts born 20 years apart when participants had reached the same age, i.e., the mid-60s. The study followed up 500 volunteers born …

Changes in Pronoun Use a Decade before Clinical Diagnosis of Alzheimer’s Dementia—Linguistic Contexts Suggest Problems in Perspective-Taking Open

Dagmar Bittner, C. Frankenberg, Johannes Schröder · 2022

The use of pronouns has been shown to change pathologically in the early phases of Alzheimer’s Dementia (AD). So far, the findings have been of a quantitative nature. Little is known, however, about the developmental path of the change, it…

Neural Correlates of Autobiographical Memory: Evidence From a Positron Emission Tomography Study in Patients With Mild Cognitive Impairment and Alzheimer's Disease Open

C. Frankenberg, Johannes Pantel, Uwe Haberkorn, Christina Degen, Monte S. Buchsbaum , et al. · 2021

Background: Autobiographical memory (AM) changes are the hallmark of Alzheimer's disease (AD) and mild cognitive impairment (MCI). In recent neuroimaging studies, AM changes have been associated with numerous cerebral sites, such as the fr…

Research diagnostic criteria for Alzheimer’s disease: findings from the LipiDiDiet randomized controlled trial Open

Anna Rosenberg, Alina Solomon, Hilkka Soininen, Pieter Jelle Visser, Kaj Blennow , et al. · 2021

Background To explore the utility of the International Working Group (IWG)-1 criteria in recruitment for Alzheimer’s disease (AD) clinical trials, we applied the more recently proposed research diagnostic criteria to individuals enrolled i…

Cerebral correlates of autobiographical memory in MCI and AD: Evidence from a positron‐emission tomography study Open

C. Frankenberg, Johannes Schröder, Uwe Haberkorn, Christina Degen, Monte S. Buchsbaum · 2020

Background Autobiographical memory (AM) changes are the hallmark of Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). In recent neuroimaging studies, AM changes were associated with numerous cerebral sites, such as the frontal …

Neurological soft signs (NSS) and cognitive deficits in HIV associated neurocognitive disorder Open

Gonzalo Forno, Fernando Henríquez, María Elena Ceballos, Matías González, Johannes Schröder , et al. · 2020

Neurological soft signs and cognition in the late course of chronic schizophrenia: a longitudinal study Open

Christina J. Herold, Céline Duval, Johannes Schröder · 2020

Neurological soft signs (NSS) and brain morphology in patients with chronic schizophrenia and healthy controls Open

Christina J. Herold, Marco Essig, Johannes Schröder · 2020

Subtle abnormalities in sensory integration, motor coordination and sequencing of complex motor acts or neurological soft signs (NSS) are characteristic phenomena in patients with schizophrenia at any stage of the illness. Previous MRI stu…

Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia Open

Li Kong, Christina J. Herold, Eric Cheung, Raymond C. K. Chan, Johannes Schröder · 2019

Neurological soft signs (NSS) are often found in patients with schizophrenia. A wealth of neuroimaging studies have reported that NSS are related to disturbed cortical-subcortical-cerebellar circuitry in schizophrenia. However, the associa…

Falscher Liebhaber. Alt werden und jung bleiben Open

Christine Hildesheim, Johannes Schröder, Hans‐Werner Wahl · 2019

„Mit 66 Jahren ist noch lange nicht Schluss!“ – so sang Udo J ürgens in den 1970er-Jahren. Heute könnte die Zeile auch „Mit 77 Jahren ...“ lauten, denn was früher noch als „Greis“ galt, wird nun als „fortgeschrittener Erwachsener“ angese…

Editorial: Neurological Soft Signs in Neuropsychiatric Conditions Open

Pablo Toro, Johannes Schröder · 2019

EDITORIAL article Front. Psychiatry, 14 January 2019Sec. Psychological Therapy and Psychosomatics Volume 9 - 2018 | https://doi.org/10.3389/fpsyt.2018.00736

Neurological soft signs (NSS) and cognitive impairment in chronic schizophrenia Open

Christina J. Herold, Céline Duval, Marc M. Lässer, Johannes Schröder · 2018

Neurological soft signs and grey matter abnormalities in individuals with ultra‐high risk for psychosis Open

Li Kong, HuiRu Cui, Tianhong Zhang, Ya Wang, Jia Huang , et al. · 2018

Neurological soft signs (NSSs), conventionally defined as subtle neurological abnormalities, are frequently found in individuals with schizophrenia. Many neuroimaging studies have also reported that NSSs are associated with grey matter cha…

Retrograde Amnesia and Disorientation after Intraocular Injection of Anti-VEGF Agents Open

Peter-Wolfgang Meyer, Matthias N. Ungerer, Johannes Schröder · 2018

We present a case of a 77-year-old male patient who was treated in our outpatient clinic for memory disorders because of episodic confusion and retrograde amnesia. The patient reported having symptoms repeatedly following intraocular treat…

F175. NEUROLOGICAL SOFT SIGNS (NSS) AND BRAIN MORPHOLOGY IN PATIENTS WITH CHRONIC SCHIZOPHRENIA AND HEALTHY CONTROLS Open

Christina J. Herold, Marc M. Lässer, Ulrich Seidl, Dušan Hirjak, Philipp A. Thomann , et al. · 2018

Subtle abnormalities in sensory integration, motor coordination and sequencing of complex motor acts or neurological soft signs (NSS) are a characteristic phenomenon in patients with schizophrenia at any stage of the illness. Previous MRI …

T67. NEUROLOGICAL SOFT SIGNS IN THE COURSE OF SCHIZOPHRENIA: A LONGITUDINAL ANALYSIS IN CHRONIC SCHIZOPHRENIA Open

Christina Herold, Céline Duval, Marc M. Lässer, Ulrich Seidl Seidl, Dušan Hirjak , et al. · 2018

Neurological soft signs (NSS) are minor (‘soft’) neurological abnormalities in sensory and motor performance, which are frequently reported in patients with schizophrenia at any stage of their illness. It has been demonstrated that NSS var…

T8. NEUROLOGICAL SOFT SIGNS (NSS) IN SCHIZOPHRENIA: AN UPDATE ON THE STATE- VERSUS TRAIT-PERSPECTIVE Open

Silke Bachmann, Johannes Schröder · 2018

Neurological soft signs (NSS) represent minor neurological signs which indicate non-specific cerebral dysfunction. Numerous studies have confirmed their presence in schizophrenia across all stages of the disease. NSS have been looked at as…

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease Open

Niklas Mattsson, Colin Groot, Willemijn J. Jansen, Susan Landau, Victor L. Villemagne , et al. · 2018

Introduction Apolipoprotein E ( APOE ) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. Methods We inclu…

Neurological Soft Signs and Psychopathology in Chronic Schizophrenia: A Cross-Sectional Study in Three Age Groups Open

Christina J. Herold, Marc M. Lässer, Ulrich Seidl, Dušan Hirjak, Philipp A. Thomann , et al. · 2018

As established in a wealth of studies subtle motor and sensory neurological abnormalities or neurological soft signs (NSS) are frequently found in patients with schizophrenia at any stage of their illness. However, the potential impact of …

Neurological Soft Signs in Schizophrenia: An Update on the State- versus Trait-Perspective Open

Silke Bachmann, Johannes Schröder · 2018

Studies manifest a conformity regarding the presence of NSS in schizophrenia patients on the one hand. On the other hand, fluctuations of NSS scores have been widely described in subgroups. Taken together results strongly support a state-t…

Demenz, die drohende Gefahr? Open

Johannes Schröder · 2018

Die Lebenserwartung in Deutschland steigt seit den 60er Jahren durchgehend an. Inzwischen liegt sie bei über 81 Jahren – das sind 10 Jahre mehr als im weltweiten Durchschnitt. Gleichzeitig wächst bei uns die Angst davor, im Alter an Demenz…

Knowledge Workers: Deregulated Work, Psychological Contracts and How These Affect Them Open

Johannes Schröder · 2018

Background: Knowledge work has been described in a boundaryless context with increasingly deregulated working conditions. How common deregulated work is and how the psychological contract (PC) of knowledge workers is affected remains uncle…

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial Open

Hilkka Soininen, Alina Solomon, Pieter Jelle Visser, Suzanne Hendrix, Kaj Blennow , et al. · 2017

Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia Open

Lutz Frölich, Oliver Peters, Piotr Lewczuk, Oliver Gruber, Stefan Teipel , et al. · 2017

Oral health-related quality of life and prosthetic status of nursing home residents with or without dementia Open

Anna‐Luisa Klotz, Alexander J. Hassel, Johannes Schröder, Peter Rammelsberg, Andreas Zenthöfer · 2017

The OHRQoL of elderly nursing home residents is substantially compromised. Several prosthetic treatment needs for residents living with or without dementia were identified. Edentulism without tooth replacement and having <5 teeth resulted …

Johannes Schröder YOU? Author Swipe