Johannes Sebastian Mutzenbach
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View article: Predictors of In-Hospital Mortality after Thrombectomy in Anterior Circulation Large Vessel Occlusion: A Retrospective, Machine Learning Study
Predictors of In-Hospital Mortality after Thrombectomy in Anterior Circulation Large Vessel Occlusion: A Retrospective, Machine Learning Study Open
Background: Despite the increased use of mechanical thrombectomy (MT) in recent years, there remains a lack of research on in-hospital mortality rates following the procedure, the primary factors influencing these rates, and the potential …
View article: Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion
Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion Open
Summary Background Stroke resulting from occlusion of the middle cerebral artery (MCA) can have devastating consequences, potentially leading to a loss of independence. This study aimed to investigate the relationship between the distance …
View article: Effect of concomitant usage of alteplase and mechanical thrombectomy for M1 middle cerebral artery occlusion on clinical outcome: a retrospective analysis of 457 patients from two centers
Effect of concomitant usage of alteplase and mechanical thrombectomy for M1 middle cerebral artery occlusion on clinical outcome: a retrospective analysis of 457 patients from two centers Open
Introduction Endovascular thrombectomy (EVT) and concomitant usage of intravenous alteplase (alteplase) in large vessel occlusion stroke may produce unwanted excess intracerebral hemorrhage (ICH). Whether this applies specifically to isola…
View article: Risk of stroke in patients with prior VKA or DOAC: A population-based real-world registry analysis
Risk of stroke in patients with prior VKA or DOAC: A population-based real-world registry analysis Open
Introduction: To date, risk assessment of suffering ischemic and hemorrhagic stroke in individuals under oral anticoagulation (OAC) is limited to hospital-based cohorts and patients with atrial fibrillation. Patients and methods: Through t…
View article: Temporal Trends of Functional Outcome in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis
Temporal Trends of Functional Outcome in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis Open
Background: Intravenous thrombolysis improves functional outcome in patients with acute stroke and frequencies of r-tPA (recombinant tissue-type plasminogen activator) treatment have been increasing over time. We aimed to assess whether fu…
View article: Neurologist-Led Management of Implantable Loop-Recorders After Embolic Stroke of Undetermined Source
Neurologist-Led Management of Implantable Loop-Recorders After Embolic Stroke of Undetermined Source Open
Introduction Upon completion of the workup for stroke, etiology cannot be identified in approximately one-third of the patients, with an embolic stroke of undetermined source (ESUS) accounting for around 50% of these cryptogenic etiologies…
View article: Supplementary Material for: Severe Leukoaraiosis Is Associated with Poor Outcome after Successful Recanalization of M1 Middle Cerebral Artery Occlusion Strokes
Supplementary Material for: Severe Leukoaraiosis Is Associated with Poor Outcome after Successful Recanalization of M1 Middle Cerebral Artery Occlusion Strokes Open
Background: Severe leukoaraiosis (LA) is an established risk factor for poor outcome after mechanical thrombectomy (MT) for large vessel occlusion stroke. There is uncertainty whether this association also applies to successf…
View article: Blood pressure characteristics in patients with acute basilar artery occlusion undergoing endovascular thrombectomy
Blood pressure characteristics in patients with acute basilar artery occlusion undergoing endovascular thrombectomy Open
Acute basilar artery occlusion (BAO) is a rare but potentially life-threatening neurological condition. While endovascular therapy (EVT) has been shown to improve outcome, there is limited knowledge about prognostic factors beyond early re…
View article: Higher Blood Pressure during Endovascular Thrombectomy in Anterior Circulation Stroke Is Associated with Better Outcomes
Higher Blood Pressure during Endovascular Thrombectomy in Anterior Circulation Stroke Is Associated with Better Outcomes Open
s In the EVT-treated patients with BP managed within the recommended limits, a better functional outcome might be achieved by targeting in-procedure BP that exceeds the preprocedure values by more than 20%.
View article: Factor VII deficiency in major artery occlusion stroke
Factor VII deficiency in major artery occlusion stroke Open
An 82-year-old woman with known Factor VII (FVII) deficiency and history of atrial fibrillation had presented with sudden onset of vertigo, slurred speech, and left-sided hemiparesis starting 20 minutes ago. Symptoms progressed rapidly to …
View article: Idarucizumab in Dabigatran-Treated Patients with Acute Ischemic Stroke Receiving Alteplase: A Systematic Review of the Available Evidence
Idarucizumab in Dabigatran-Treated Patients with Acute Ischemic Stroke Receiving Alteplase: A Systematic Review of the Available Evidence Open
View article: State of the art – Akuttherapie des ischämischen Schlaganfalls
State of the art – Akuttherapie des ischämischen Schlaganfalls Open
Lange Zeit galt die systemische Thrombolyse mit rt-PA als einzige evidenzbasierte kausale Akuttherapie des ischämischen Schlaganfalls. Die Ergebnisse von 6 positiven randomisierten Studien liefern in großer Übereinstimmung eine Überlegenhe…
View article: Delayed Hospital Presentation and Neuroimaging in Non-surgical Spinal Cord Infarction
Delayed Hospital Presentation and Neuroimaging in Non-surgical Spinal Cord Infarction Open
Our study found a time lag from symptom onset to hospital presentation and spinal cord MRI in patients with acute spinal cord infarction. These findings point at low clinical suspicion of spinal cord syndromes and limited recognition as a …
View article: Real-life experience with the specific reversal agent idarucizumab for the management of emergency situations in dabigatran-treated patients: a series of 11 cases
Real-life experience with the specific reversal agent idarucizumab for the management of emergency situations in dabigatran-treated patients: a series of 11 cases Open
View article: Intracranial Thrombus Morphology and Composition Undergoes Time-Dependent Changes in Acute Ischemic Stroke: A CT Densitometry Study
Intracranial Thrombus Morphology and Composition Undergoes Time-Dependent Changes in Acute Ischemic Stroke: A CT Densitometry Study Open
The aim of our study was to assess whether cerebral artery clots undergo time-dependent morphological and compositional changes in acute ischemic stroke. We performed a retrospective chart review of patients admitted within 5 h from sympto…
View article: Intravenous thrombolysis in acute ischemic stroke after dabigatran reversal with idarucizumab – a case report
Intravenous thrombolysis in acute ischemic stroke after dabigatran reversal with idarucizumab – a case report Open
Much excitement has been generated with the approval of idarucizumab, a humanized monoclonal antigen‐binding antibody fragment that is capable of reversing the anticoagulant activity of dabigatran. Here, we describe our initial experience …
View article: Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study
Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study Open
View article: Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke
Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke Open
We explored whether clot density in middle cerebral artery (MCA) occlusion is related to clinical variables, stroke etiology, blood constituents, and prestroke medication. We performed a retrospective chart review of patients with acute is…
View article: Therapeutic challenges after successful thrombectomy in a patient with an antiphospholipid syndrome associated M1-occlusion: A case report
Therapeutic challenges after successful thrombectomy in a patient with an antiphospholipid syndrome associated M1-occlusion: A case report Open
Backround Stroke is a frequent disorder in patients with an antiphospholipid syndrome (APS). Due to a high risk for further thromboembolic events, appropriate anticoagulation therapy in patients with an APS-associated stroke seems mandator…