Johannes Vester
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View article: Comprehensive Mitigation of Peripheral and Central Stress Responses by Nx4: Insights From EEG and Heart Rate Variability in Post‐Stress Resting State
Comprehensive Mitigation of Peripheral and Central Stress Responses by Nx4: Insights From EEG and Heart Rate Variability in Post‐Stress Resting State Open
Objective Stress from daily psychosocial challenges is a significant health concern with limited pharmacological treatment options. Psychosocial stress triggers distinct responses in the autonomic and central nervous systems, measurable vi…
View article: C-REGS2—A multinational, high-quality comparative effectiveness study of Cerebrolysin in moderate acute ischemic stroke
C-REGS2—A multinational, high-quality comparative effectiveness study of Cerebrolysin in moderate acute ischemic stroke Open
Background: The main objective of the Cerebrolysin REGistry Study in Stroke 2 (C-REGS2) was to systematically record the routine clinical use of Cerebrolysin in patients with moderate ischemic stroke (IS) following the principles of a pros…
View article: Topical Treatment Is Effective and Safe for Acute Ankle Sprains: The Multi-Center Double-Blind Randomized Placebo-Controlled TRAUMED Trial
Topical Treatment Is Effective and Safe for Acute Ankle Sprains: The Multi-Center Double-Blind Randomized Placebo-Controlled TRAUMED Trial Open
Background: Topical NSAIDs are widely used to treat ankle sprains. Traumed (Tr14) gel is a multicomponent formulation, demonstrating inflammation-resolution properties. Methods: This multicenter, double-blind trial investigated the efficac…
View article: Correction: Trait anxiety is related to Nx4’s efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers
Correction: Trait anxiety is related to Nx4’s efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers Open
View article: Trait anxiety is related to Nx4’s efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers
Trait anxiety is related to Nx4’s efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers Open
Background The multicomponent drug Neurexan (Nx4) was shown to reduce the neural stress network activation. We now investigated its effects on stress-induced resting state functional connectivity (RSFC) in dependence of trait anxiety (TA),…
View article: Nx4 Modulated Resting-State Functional Connectivity Between Amygdala and Prefrontal Cortex in a Placebo-Controlled, Crossover Trial
Nx4 Modulated Resting-State Functional Connectivity Between Amygdala and Prefrontal Cortex in a Placebo-Controlled, Crossover Trial Open
Background: The basic functional organization of the resting brain, assessed as resting-state functional connectivity (rsFC), can be affected by previous stress experience and it represents the basis on which subsequent stres…
View article: Nx4 attenuated stress‐induced activity of the anterior cingulate cortex—A <i>post‐hoc</i> analysis of a randomized placebo‐controlled crossover trial
Nx4 attenuated stress‐induced activity of the anterior cingulate cortex—A <i>post‐hoc</i> analysis of a randomized placebo‐controlled crossover trial Open
Objective Stress‐related symptoms are associated with significant health and economic burden. Several studies suggest Nx4 for the pharmacological management of the stress response and investigated the underlying neural processes. Here we h…
View article: Nx4 Reduced Susceptibility to Distraction in an Attention Modulation Task
Nx4 Reduced Susceptibility to Distraction in an Attention Modulation Task Open
Background: Stress adversely affects the attentional focus, the active concentration on stimuli, and increases susceptibility to distraction. To experimentally explore the susceptibility to distraction, the Attention Modulation by Salience…
View article: European Academy of Neurology and European Federation of Neurorehabilitation Societies guideline on pharmacological support in early motor rehabilitation after acute ischaemic stroke
European Academy of Neurology and European Federation of Neurorehabilitation Societies guideline on pharmacological support in early motor rehabilitation after acute ischaemic stroke Open
Background and purpose Early pharmacological support for post‐stroke neurorehabilitation has seen an abundance of mixed results from clinical trials, leaving practitioners at a loss regarding the best options to improve patient outcomes. T…
View article: Cerebrolysin after moderate to severe traumatic brain injury: prospective meta-analysis of the CAPTAIN trial series
Cerebrolysin after moderate to severe traumatic brain injury: prospective meta-analysis of the CAPTAIN trial series Open
The meta-analysis of the CAPTAIN trials confirms the safety and efficacy of Cerebrolysin after moderate-severe TBI, opening a new horizon for neurorecovery in this field. Integration of Cerebrolysin into existing guidelines should be consi…
View article: C-REGS 2 - Design and methodology of a high-quality comparative effectiveness observational trial
C-REGS 2 - Design and methodology of a high-quality comparative effectiveness observational trial Open
The main aim of this study is to systematically record Cerebrolysin treatment modalities and concomitant medication, according to local standards, in patients with moderate to severe neurological deficits after acute ischemic stroke and to…
View article: Replication Data for: Cerebrolysin after Moderate-Severe Traumatic Brain Injury: the CAPTAIN Meta-Analysis
Replication Data for: Cerebrolysin after Moderate-Severe Traumatic Brain Injury: the CAPTAIN Meta-Analysis Open
This dataset offers individual patient data for the CAPTAIN trials, information used to develop the CAPTAIN meta-analysis. The objective of this prospective meta-analysis was to evaluate the efficacy and safety of Cerebrolysin for moderate…
View article: fMRI Revealed Reduced Amygdala Activation after Nx4 in Mildly to Moderately Stressed Healthy Volunteers in a Randomized, Placebo-Controlled, Cross-Over Trial
fMRI Revealed Reduced Amygdala Activation after Nx4 in Mildly to Moderately Stressed Healthy Volunteers in a Randomized, Placebo-Controlled, Cross-Over Trial Open
View article: Correction to: Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I—a randomized, placebo-controlled, double-blind, Asian-Pacific trial
Correction to: Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I—a randomized, placebo-controlled, double-blind, Asian-Pacific trial Open
View article: CAPTAIN_AnalysisData.tab
CAPTAIN_AnalysisData.tab Open
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View article: Regeneration of Denervated Skeletal Muscles – Brunelli’s CNS-PNS Paradigm
Regeneration of Denervated Skeletal Muscles – Brunelli’s CNS-PNS Paradigm Open
The restoration of voluntary muscle activity in posttraumatic paraplegia in both animal experiments and other clinical applications requires reproducibility of a technically-demanding microsurgical procedure, limited by physicians’ underst…
View article: Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I—a randomized, placebo-controlled, double-blind, Asian-Pacific trial
Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I—a randomized, placebo-controlled, double-blind, Asian-Pacific trial Open
The above article was published online with incorrect abbreviations in Figures 2 and 3 last sentence of the legend. HDA should be corrected to HADS.
View article: Efficacy and safety of Cerebrolysin treatment in early recovery after acute ischemic stroke: a randomized, placebo-controlled, double-blinded, multicenter clinical trial.
Efficacy and safety of Cerebrolysin treatment in early recovery after acute ischemic stroke: a randomized, placebo-controlled, double-blinded, multicenter clinical trial. Open
Background and Purpose : The aim of this study was to evaluate the efficacy, safety, and tolerability of cerebrolysin in the early recovery phase after acute ischemic stroke. Methods. This prospective, randomized, doub…
View article: Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials
Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials Open
This meta-analysis combines the results of nine ischemic stroke trials, assessing efficacy of Cerebrolysin on global neurological improvement during early post-stroke period. Cerebrolysin is a parenterally administered neuropeptide prepara…
View article: Letter by Vester et al Regarding Article, “Hope Dies Last—Evidence Again Fails to Support a Neuroprotectant: Cerebrolysin for Acute Ischemic Stroke”
Letter by Vester et al Regarding Article, “Hope Dies Last—Evidence Again Fails to Support a Neuroprotectant: Cerebrolysin for Acute Ischemic Stroke” Open
View article: Safety and efficacy of Cerebrolysin in motor function recovery after stroke: a meta-analysis of the CARS trials
Safety and efficacy of Cerebrolysin in motor function recovery after stroke: a meta-analysis of the CARS trials Open
View article: Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial
Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial Open
Background Systemic enzyme therapy may improve symptoms of exhaustive eccentric exercise due to anti-inflammatory properties. Methods In a randomised, placebo-controlled, two-stage clinical trial, systemic enzyme therapy (Wobenzym) was adm…
View article: Cerebrolysin and Recovery After Stroke (CARS)
Cerebrolysin and Recovery After Stroke (CARS) Open
Background and Purpose— The aim of this trial was to investigate whether stroke patients who receive Cerebrolysin show improved motor function in the upper extremities at day 90 compared with patients who receive a placebo. Methods— This s…
View article: <scp>GFAP</scp> and antibodies against <scp>NMDA</scp> receptor subunit <scp>NR</scp>2 as biomarkers for acute cerebrovascular diseases
<span>GFAP</span> and antibodies against <span>NMDA</span> receptor subunit <span>NR</span>2 as biomarkers for acute cerebrovascular diseases Open
We studied whether the serum levels of glial fibrillary acidic protein ( GFAP ) and of antibodies against the N ‐methyl‐ d ‐aspartate receptor subunit NR 2 ( NR 2 R NMDA ) can discriminate between intracerebral haemorrhage ( ICH ) and isch…