Johannes Wölfer
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View article: Blockade of inhibitory killer cell immunoglobulin-like receptors and IL-2 triggering reverses the functional hypoactivity of tumor-derived NK-cells in glioblastomas
Blockade of inhibitory killer cell immunoglobulin-like receptors and IL-2 triggering reverses the functional hypoactivity of tumor-derived NK-cells in glioblastomas Open
View article: Combined Fluorescence-Guided Resection and Intracavitary Thermotherapy with Superparamagnetic Iron-Oxide Nanoparticles for Recurrent High-Grade Glioma: Case Series with Emphasis on Complication Management
Combined Fluorescence-Guided Resection and Intracavitary Thermotherapy with Superparamagnetic Iron-Oxide Nanoparticles for Recurrent High-Grade Glioma: Case Series with Emphasis on Complication Management Open
Background: Concepts improving local tumor control in high-grade glioma (HGG) are desperately needed. The aim of this study is to report an extended series of cases treated with a combination of 5-ALA-fluorescence-guided resection (FGR) an…
View article: SURG-12. “NANOPASTE” THERAPY AS POTENTIAL TREATMENT OPTION FOR RECURRENT GLIOBLASTOMA
SURG-12. “NANOPASTE” THERAPY AS POTENTIAL TREATMENT OPTION FOR RECURRENT GLIOBLASTOMA Open
BACKGROUND We recently showed that intracavitary thermotherapy with superparamagnetic iron-oxide nanoparticles can induce persistent inflammatory reactions which might lead to long-term stabilization in recurrent glioblastoma (GBM) patient…
View article: Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients
Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients Open
View article: Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas?
Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? Open
BACKGROUND Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration. OBJECTIVE To determine if fluorescence represents a prognostic marker in…
View article: Conscious sedation with dexmedetomidine compared with asleep-awake-asleep craniotomies in glioma surgery: an analysis of 180 patients
Conscious sedation with dexmedetomidine compared with asleep-awake-asleep craniotomies in glioma surgery: an analysis of 180 patients Open
OBJECTIVE Awake craniotomies have become a feasible tool over time to treat brain tumors located in eloquent regions. Different techniques have been applied in neurooncology centers. Both “asleep-awake-asleep” (asleep) and “conscious sedat…
View article: SURG-32. COMBINED INTRACAVITARY THERMOTHERAPY WITH IRON-OXIDE NANOPARTICLES AND RADIOTHERAPY AS A PROMISING TREATMENT MODALITY IN RECURRENT GBM
SURG-32. COMBINED INTRACAVITARY THERMOTHERAPY WITH IRON-OXIDE NANOPARTICLES AND RADIOTHERAPY AS A PROMISING TREATMENT MODALITY IN RECURRENT GBM Open
BACKGROUND: Treatment options for glioblastoma patients (GBM) at the time of recurrence are still limited. METHODS: We report a series of six recurrent GBM patients (median age: 62.5 years, median time to first recurrence: 5.7 months, rang…
View article: P16.22 Awake-Awake-Awake with dexmedetomidine compared to asleep-awake-asleep craniotomies in glioma surgery - an analysis from 180 glioma patients
P16.22 Awake-Awake-Awake with dexmedetomidine compared to asleep-awake-asleep craniotomies in glioma surgery - an analysis from 180 glioma patients Open
\nIntroduction: For over 70Â years, awake craniotomies have been part of treatment of gliomas located in so called âeloquent regionsâ. The patientsâ compliance plays an important role in the success of each surgery. Finding the optim…
View article: Dual-labeling with 5–aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note
Dual-labeling with 5–aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note Open
OBJECTIVE Fluorescence guidance with 5–aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas. However, one limitation is the low intensity of blue light for background illumination. Fluorescein has recently been reintro…
View article: Multimodal Imaging of Patients With Gliomas Confirms <sup>11</sup>C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy
Multimodal Imaging of Patients With Gliomas Confirms <sup>11</sup>C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy Open
The value of combined L-( methyl-[ 11 C]) methionine positron-emitting tomography (MET-PET) and magnetic resonance imaging (MRI) with regard to tumor extent, entity prediction, and therapy effects in clinical routine in patients with suspi…
View article: RTHP-22. INFLAMMATORY RESPONSE AFTER MODIFIED NANOTHERM AND RADIOTHERAPY OF RECURRENT GLIOBLASTOMA
RTHP-22. INFLAMMATORY RESPONSE AFTER MODIFIED NANOTHERM AND RADIOTHERAPY OF RECURRENT GLIOBLASTOMA Open
There is increasing interest in local tumor ablative treatment modalities which induce immunogenic cell death and the generation of tumor specific immune responses. We report the case of a 42-years old female with recurrent GBM who was tre…
View article: Surgery for meningioma in the elderly and long-term survival: comparison with an age- and sex-matched general population and with younger patients
Surgery for meningioma in the elderly and long-term survival: comparison with an age- and sex-matched general population and with younger patients Open
OBJECTIVE The purpose of this study was to compare long-term prognosis after meningioma surgery in elderly and younger patients as well as to compare survival of elderly patients with surgically treated meningioma to survival rates for the…
View article: CD4<sup>+</sup>T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients
CD4<sup>+</sup>T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients Open
Background Myeloid-derived suppressor cells (MDSCs) comprise a heterogeneous population of myeloid cells that are significantly expanded in cancer patients and are associated with tumor progression. Methods Multicolor flow cytometry was u…
View article: The Value of 5-Aminolevulinic Acid in Low-grade Gliomas and High-grade Gliomas Lacking Glioblastoma Imaging Features
The Value of 5-Aminolevulinic Acid in Low-grade Gliomas and High-grade Gliomas Lacking Glioblastoma Imaging Features Open
Age, tumor volume, and F-FET PET uptake are factors predicting 5-ALA-induced fluorescence in gliomas without typical glioblastoma imaging features. Fluorescence was associated with an increased Ki-67/MIB-1 index and high-grade pathology. W…
View article: Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study
Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study Open
OBJECT Delayed ischemic neurological deficits (DINDs) and cerebral vasospasm (CVS) are responsible fora poor outcome in patients with aneurysmal subarachnoid hemorrhage (SAH), most likely because of a decreased availability of nitric oxide…
View article: Simultaneous fluorescein sodium and 5-ALA in fluorescence-guided glioma surgery
Simultaneous fluorescein sodium and 5-ALA in fluorescence-guided glioma surgery Open
Dear Editor, Five-aminolevulinic acid (5-ALA)-derived fluorescence is approved for fluorescence-guided resections of malignant gliomas, relying on selective synthesis and accumulation of protoporphyrin IX (PPIX) within malignant glioma cel…