Andrew J. Bennett
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View article: Alternative splicing of KLF4 in myeloid cells: implications for cellular plasticity and trained immunity in cancer and inflammatory disease
Alternative splicing of KLF4 in myeloid cells: implications for cellular plasticity and trained immunity in cancer and inflammatory disease Open
The role of transcription factor Krüppel-like factor 4 (KLF4) in the modulation of myeloid cells is well known. KLF4 is involved in the differentiation and polarization of monocytes and macrophages as part of the immune response after infe…
View article: Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells
Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells Open
Polymeric immunoglobulin receptor (PIGR) has a major role in mucosal immunity as a transporter of polymeric immunoglobulin across the epithelial cells. The aim of this study was to determine the effect of PIGR on cellular behaviours and ch…
View article: A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation
A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation Open
Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation within hepatocytes, but the relative contributions of different macronutrients is still unclear. We investigated the impact of fatty acids, glucose and fructose on li…
View article: Immunological contributions to age-dependent variations in behavioural responses to cutaneous inflammation
Immunological contributions to age-dependent variations in behavioural responses to cutaneous inflammation Open
Systemic responses to immune challenge are immature at birth. However exposure to experimental inflammogens are able to produce an immunologic response which is characterised by swelling and oedema but, unlike in adults, does not result in…
View article: Integrins as a drug target in liver fibrosis
Integrins as a drug target in liver fibrosis Open
As the worldwide prevalence of chronic liver diseases is high and continuing to increase, there is an urgent need for treatment to prevent cirrhosis‐related morbidity and mortality. Integrins are heterodimeric cell‐surface proteins that ar…
View article: O9 M1 macrophages evoke an increase in PIGR expression in MDA-MB468 breast cancer cells through interlukin-1β
O9 M1 macrophages evoke an increase in PIGR expression in MDA-MB468 breast cancer cells through interlukin-1β Open
Introduction The polymeric immunoglobulin receptor (PIGR) is a transmembrane protein, which transports polymeric immunoglobulin (pIg) across the epithelial cells. High expression of PIGR in breast cancer has been reported to associate with…
View article: O24 Predictive and prognostic roles of polymeric immunoglobuilin receptor in breast cancer
O24 Predictive and prognostic roles of polymeric immunoglobuilin receptor in breast cancer Open
Introduction Neoadjuvant chemotherapy (NAC) is used with increasing frequency as the primary treatment for breast cancer. Pathological complete response (pCR) which contributes to survival benefit is achieved in only 25–30% of patients wit…
View article: O25 Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells
O25 Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells Open
Introduction Polymeric immunoglobulin receptor (PIGR) has a major role in mucosal immunity as a transporter of polymeric immunoglobulin across the epithelial cells. PIGR expression increases in various cancers and relates to patient outcom…
View article: Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome: Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine
Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome: Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine Open
Biopsies from a well-characterized IBS-D cohort showed no substantial inflammation. Mesalazine has little effect on gene expression and its previous reported effect on fecal microbiota associated with much greater inflammation found in inf…
View article: Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release
Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release Open
We report the fabrication of a coaxial electrospun scaffold with a bioactive molecule in the core and a protein conjugated at the surface. To construct the scaffold, we chose polyethylene oxide for the core material and a polycaprolactone/…
View article: Spinal neuronal excitability and neuroinflammation in a model of chemotherapeutic neuropathic pain: targeting the resolution pathways
Spinal neuronal excitability and neuroinflammation in a model of chemotherapeutic neuropathic pain: targeting the resolution pathways Open
Background Neuroinflammation is a critical feature of sensitisation of spinal nociceptive processing in chronic pain states. We hypothesised that the resolvin pathways, a unique endogenous control system, may ameliorate aberrant spinal pro…
View article: Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain
Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain Open
Brain-derived neurotrophic factor (BDNF) and the high-affinity receptor tropomyosin receptor kinase B (TrkB) have important roles in neuronal survival and in spinal sensitization mechanisms associated with chronic pain. Recent clinical evi…
View article: Comparison of primary human hepatocytes and HepG2 cells as models to study the development of hepatic steatosis
Comparison of primary human hepatocytes and HepG2 cells as models to study the development of hepatic steatosis Open
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View article: Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB
Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB Open
Adiposity and adipokines are implicated in the loss of skeletal muscle mass with age and in several chronic disease states. The aim of this study was to determine the effects of human obese and lean subcutaneous adipose tissue secretome on…
View article: Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development
Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development Open
Significant age- and experience-dependent remodelling of spinal and supraspinal neural networks occur, resulting in altered pain responses in early life. In adults, endogenous opioid peptide and endocannabinoid (ECs) pain control systems e…
View article: Effects of short‐term energy restriction on liver lipid content and inflammatory status in severely obese adults: <scp>R</scp> esults of a randomized controlled trial using 2 dietary approaches
Effects of short‐term energy restriction on liver lipid content and inflammatory status in severely obese adults: <span>R</span> esults of a randomized controlled trial using 2 dietary approaches Open
Short‐term very‐low‐energy diets ( VLEDs ) are used in clinical practice prior to bariatric surgery, but regimens vary and outcomes of a short intervention are unclear. We examined the effect of 2 VLEDs , a food‐based diet ( FD ) and a mea…
View article: Bioprinting Using Mechanically Robust Core–Shell Cell‐Laden Hydrogel Strands
Bioprinting Using Mechanically Robust Core–Shell Cell‐Laden Hydrogel Strands Open
The strand material in extrusion‐based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical …
View article: Erratum: Skeletal Muscle Metabolic Gene Expression Is Not Affected by Dichloroacetate-Mediated Modulation of Substrate Utilisation
Erratum: Skeletal Muscle Metabolic Gene Expression Is Not Affected by Dichloroacetate-Mediated Modulation of Substrate Utilisation Open
Aim: This study investigated whether changing fuel use, by increasing pyruvate dehydrogenase complex (PDC) flux, independently of plasma substrate availability and insulin signalling, would alter metabolic gene expression. Methods: The PDC…
View article: Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain
Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain Open
Objective Pain is a major symptom of osteoarthritis (OA); currently available analgesics either do not provide adequate pain relief or are associated with serious side effects. The aim of this study was to investigate the therapeutic poten…
View article: Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models Open
Our data suggest that peripheral inflammation-mediated changes in spinal FLAP expression may contribute to the novel inhibitory effects of spinal AT-RvD1 on WDR neuronal excitability, which are mediated by FPR2/ALX receptors. Inflammatory-…
View article: The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain
The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain Open
We demonstrate that anti-NGF antibody treatment attenuates OA pain behaviour despite permitting cartilage damage and synovitis. Indirect effects on subchondral bone remodelling may contribute to the analgesic effects of NGF blockade.