Explanipedia

Clinical Characteristics of Necrotizing Enterocolitis Diagnosed by Independent Adjudication of Abdominal Radiographs, Laparotomy, or Autopsy in Preterm Infants in the “Connection Trial” Open

Josef Neu, Rachana Singh, Mihaela Demetrian, Jaime Flores-Torres, Mark L. Hudak , et al. · 2024

Objective Necrotizing enterocolitis (NEC) classically is diagnosed by radiographic demonstration of pneumatosis intestinalis/portal venous gas (PI/PVG). This study examines clinical characteristics of NEC confirmed by independent evaluatio…

Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis Open

Ariel A. Salas, Elizabeth Gunn, Waldemar A. Carlo, Edward F. Bell, Abhik Das , et al. · 2024

Importance Observational studies often report that anemia and red blood cell (RBC) transfusions are associated with a higher risk of necrotizing enterocolitis (NEC) among extremely low-birthweight (ELBW) infants. Objective To evaluate whet…

Measuring practice preference variation for quality improvement: development of the Neonatology Survey of Interdisciplinary Groups in Healthcare Tool (NSIGHT) Open

Emily Whitesel, Helen Healy, Wenyang Mao, DeWayne M. Pursley, John A. F. Zupancic , et al. · 2023

Background Understanding behavioural psychology and the human side of change are guiding principles for quality improvement (QI). Tools to measure these to guide improvement efforts are lacking. Methods We created a clinical vignette-based…

Asperger’s syndrome – about time to rename it? Open

Cynthia F. Bearer, Steven H. Abman, Carlo Agostoni, Phil Ballard, Joe Bliss , et al. · 2023

Systemic corticosteroids for the prevention of bronchopulmonary dysplasia, a network meta-analysis Open

Susanne Hay, Colleen Ovelman, John A. F. Zupancic, Lex W. Doyle, Wes Onland , et al. · 2023

While early treatment with moderate-dose dexamethasone or late treatment with high-dose dexamethasone may lead to the best effects for survival without BPD, the certainty of the evidence is low. There is insufficient evidence to guide this…

Prediction and Prevention of Preterm Birth: Secondary Analysis of a Randomized Intervention Trial Open

C. Andrew Combs, John A. F. Zupancic, Michael Walker, Jing Shi · 2023

Our objective was to evaluate whether pregnancy is prolonged by the use of a proteomics-based maternal serum screening test followed by treatment interventions. This is a secondary analysis of the PREVENT-PTB randomized trial comparing scr…

Prediction and Prevention of Preterm Birth: Secondary Analysis of a Randomized Intervention Trial Open

C. Andrew Combs, John A. F. Zupancic, Michael Walker, Jing Shi · 2023

Our objective was to evaluate whether pregnancy is prolonged by use of a proteomics-based maternal serum screening test followed by treatment interventions. This is a secondary analysis of the PREVENT-PTB randomized trial comparing screeni…

Machine learning: remember the fundamentals Open

Kristyn Beam, John A. F. Zupancic · 2022

Clinical and economic evaluation of a proteomic biomarker preterm birth risk predictor: cost-effectiveness modeling of prenatal interventions applied to predicted higher-risk pregnancies within a large and diverse cohort Open

Julja Burchard, Glenn Markenson, George R. Saade, Louise C. Laurent, Kent Heyborne , et al. · 2022

Modeled evaluation of a biomarker-based test-and-treat strategy in a diverse population predicts clinically and economically meaningful improvements in neonatal and maternal outcomes.

Physician wellbeing during the COVID-19 pandemic: an acute on chronic condition Open

Amanda A. Sandford, John A. F. Zupancic · 2021

Clinical and economic evaluation of a proteomic biomarker preterm birth risk predictor: Cost-effectiveness modeling of prenatal interventions applied to predicted higher-risk pregnancies within a large and diverse cohort Open

Julja Burchard, Glenn Markenson, George R. Saade, Louise C. Laurent, Kent Heyborne , et al. · 2021

Objectives Preterm birth occurs in more than 10% of U.S. births and is the leading cause of U.S. neonatal deaths, with estimated annual costs exceeding $25 billion USD. Using real-world data, we modeled the potential clinical and economic …

Cost-Effectiveness of a Proteomic Test for Preterm Birth Prediction Open

Michael Grabner, Julja Burchard, Chi Nguyen, Haechung Chung, Nilesh Gangan , et al. · 2021

Use of a novel prognostic test during pregnancy to identify women at risk of PTB combined with evidence-based treatment is estimated to reduce total costs while preventing PTBs and their consequences.

Quantifying the variation in neonatal transport referral patterns using network analysis Open

Sarah N. Kunz, Daniel Helkey, Marinka Žitnik, Ciaran S. Phibbs, Joseph Rigdon , et al. · 2021

COVID-19 preparedness—a survey among neonatal care providers in low- and middle-income countries Open

Claus Klingenberg, Sahil Tembulkar, Anna Lavizzari, Charles Christoph Roehr, Danielle E. Y. Ehret , et al. · 2021

Neonates in the COVID-19 pandemic Open

Eleanor J. Molloy, Anna Lavizzari, Claus Klingenberg, Jochen Profit, John A. F. Zupancic , et al. · 2020

Quantifying the Where and How Long of Newborn Care Open

John A. F. Zupancic, Sarah N. Kunz, DeWayne M. Pursley · 2020

* Abbreviation: RU-IP — : resource use inflection point In this issue of Pediatrics , Goldin et al1 report their exploration of a “resource use inflection point” (RU-IP) for infants in 43 NICUs. They define the RU-IP as the da…

Using Neonatal Intensive Care Units More Wisely for At-Risk Newborns and Their Families Open

DeWayne M. Pursley, John A. F. Zupancic · 2020

David Braun, MD; Eric Braun, BA; Vicki Chiu, MS; Anthony E. Burgos, MD, MPH; Mandhir Gupta, MD; Marianna Volodarskiy, MSN, RN, NE-BC; Darios Getahun, MD, MPH, PhD

International comparison of guidelines for managing neonates at the early phase of the SARS-CoV-2 pandemic Open

Anna Lavizzari, Claus Klingenberg, Jochen Profit, John A. F. Zupancic, Alexis S. Davis , et al. · 2020

Caring for Newborns Born to Mothers With COVID-19: More Questions Than Answers Open

Munish Gupta, John A. F. Zupancic, DeWayne M. Pursley · 2020

As the coronavirus disease 2019 (COVID-19) pandemic continues, its impact on newborns remains uncertain. Early reports from China suggested that although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection could be assoc…

Cost-effectiveness of Antenatal Corticosteroid Therapy vs No Therapy in Women at Risk of Late Preterm Delivery Open

Cynthia Gyamfi‐Bannerman, John A. F. Zupancic, Grecio J. Sandoval, William A. Grobman, Sean C. Blackwell , et al. · 2019

The findings suggest that antenatal betamethasone treatment is associated with a statistically significant decrease in health care costs and with improved outcomes; thus, this treatment may be an economically desirable strategy.

Evaluating the Efficacy of Seattle-PAP for the Respiratory Support of Premature Neonates: Study Protocol for a Randomized Controlled Trial Open

Carl H. Backes, RNC-NIC BSN Jennifer L. Notestine, RN-BC MS Jane M. Lamp, IBCLC FACCE RN MSN Jeanne C. Balough, Allison M. Notestine , et al. · 2018

Background : At birth, the majority of neonates born at <30 weeks of gestation require respiratory support to facilitate transition and ensure adequate gas exchange. Although the optimal approach to the initial respiratory management is un…

Adherence of Newborn-Specific Antibiotic Stewardship Programs to CDC Recommendations Open

Timmy Ho, Madge E. Buus‐Frank, Erika M. Edwards, Kate A. Morrow, Karla Ferrelli , et al. · 2018

BACKGROUND: The Centers for Disease Control and Prevention (CDC) published the Core Elements of Hospital Antibiotic Stewardship Programs (ASPs), while the Choosing Wisely for Newborn Medicine Top 5 list identified antibiotic therapy as an …

Seattle-PAP trial: A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Neonates Open

Carl H. Backes, RNC-NIC BSN Jennifer L. Notestine, RN-BC MS Jane M. Lamp, IBCLC FACCE RN MSN Jeanne C. Balough, Allison M. Notestine , et al. · 2018

Background: At birth, the majority of neonates born at <30 weeks of gestation require respiratory support to facilitate transition and ensure adequate gas exchange. Although the optimal approach to the initial respiratory management is unc…

Value-based care: the preference of outcome over prediction Open

Timmy Ho, Dmitry Dukhovny, John A. F. Zupancic, DeWayne M. Pursley · 2018

Network analysis: a novel method for mapping neonatal acute transport patterns in California Open

S. Kunz, John A. F. Zupancic, Joseph Rigdon, Ciaran S. Phibbs, H C Lee , et al. · 2017

Longer and deeper cooling for hypoxic ischemic encephalopathy in neonates does not reduce mortality Open

Dmitry Dukhovny, John A. F. Zupancic · 2017

Commentary on: Shankaran S, Laptook AR, Pappas A, McDonald SA, Das A, Tyson JE, Poindexter BB, Schibler K, Bell EF, Heyne RJ, Pedroza C, Bara R, Van Meurs KP, Grisby C, Petrie Huitema CM, Garg M, Ehrenkranz RA, Shepherd EG, Chalak LF, Hamr…

Clinical and Cost Impact Analysis of a Novel Prognostic Test for Early Detection of Preterm Birth Open

John A. F. Zupancic, James M. Greenberg, Susan Garfield, Stephen Thung, Jay D. Iams , et al. · 2016

Objective The objective of this study was to evaluate the potential impact to the U.S. health care system by adopting a novel test that identifies women at risk for spontaneous preterm birth. Methods A decision-analytic model…

“Waste not, want not”, or the cost of doing the wrong thing Open

Haresh Kirpalani, John A. F. Zupancic · 2016

“Waste not, want not”, or the cost of doing the wrong thing Open

Haresh Kirpalani, John A. F. Zupancic · 2015

Choosing Wisely in Newborn Medicine: Five Opportunities to Increase Value Open

Timmy Ho, Dmitry Dukhovny, John A. F. Zupancic, Don Goldmann, Jeffrey D. Horbar , et al. · 2015

BACKGROUND: The use of unnecessary tests and treatments contributes to health care waste. The “Choosing Wisely” campaign charges medical societies with identifying such items. This report describes the identification of 5 tests and treatme…

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