John A. Hamilton
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View article: Therapeutic blockade of CCL17 in obesity-exacerbated osteoarthritic pain and disease
Therapeutic blockade of CCL17 in obesity-exacerbated osteoarthritic pain and disease Open
Objectives We previously reported that CCL17 gene-deficient mice are protected from developing pain-like behaviour and exhibit less disease in destabilization of medial meniscus (DMM)-induced OA, as well as in high-fat diet (HFD)-exacerbat…
View article: The Anatomic Pathology Hospitalist Model : A Novel Approach to Frozen Section Practice in a Tertiary Care Center
The Anatomic Pathology Hospitalist Model : A Novel Approach to Frozen Section Practice in a Tertiary Care Center Open
Context.— Challenges to staffing a high-quality frozen section service include consolidation of health systems and pathology practices, off-campus relocation of some pathology offices, growing numbers of stand-alone surgery centers, and su…
View article: The mode of action of IL-23 in experimental inflammatory arthritic pain and disease
The mode of action of IL-23 in experimental inflammatory arthritic pain and disease Open
Objectives We have previously reported using gene-deficient mice that the interleukin (IL)-23p19 subunit is required for the development of innate immune-driven arthritic pain and disease. We aimed to explore here, using a number of in viv…
View article: IL-23p19 in osteoarthritic pain and disease
IL-23p19 in osteoarthritic pain and disease Open
The findings support the possible targeting of IL-23 as a treatment for OA pain and disease progression.
View article: IL-23 regulation of myeloid cell biology during inflammation
IL-23 regulation of myeloid cell biology during inflammation Open
Interleukin (IL)-23 is implicated in the pathogenesis of several inflammatory diseases and is usually linked with helper T cell (Th17) biology. However, there is some data linking IL-23 with innate immune biology in such diseases. We there…
View article: Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes
Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes Open
Transforming growth factor-β (TGF-β) is a pleiotropic cytokine essential for multiple biological processes, including the regulation of inflammatory and immune responses. One of the important functions of TGF-β is the suppression of the pr…
View article: TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility
TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility Open
Background Mechanosensation is an important trigger of physiological processes in the gastrointestinal tract. Aberrant responses to mechanical input are associated with digestive disorders, including visceral hypersensitivity. Transient Re…
View article: Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis
Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis Open
Glucocorticoids (GCs) are potent anti-inflammatory agents and are broadly used in treating rheumatoid arthritis (RA) patients, albeit with adverse side effects associated with long-term usage. The negative consequences of GC therapy provid…
View article: Targeting transcription factors for therapeutic benefit in rheumatoid arthritis
Targeting transcription factors for therapeutic benefit in rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes pain and disability. Many of the currently available drugs for treating RA patients are aimed at halting the progression of the disease and alleviating …
View article: Supplementary Figure 4 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Supplementary Figure 4 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
PDF file - 120K, Supplementary Figure 4: The oral CSF-1R inhibitor, CYC11645, increases metastasis to lung.
View article: Supplementary Figure 7 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Supplementary Figure 7 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
PDF file - 106K, Supplementary Figure 7: CSF-1R expression and breast cancer survival.
View article: Supplementary Methods, Figure Legends from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Supplementary Methods, Figure Legends from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
PDF file - 114K
View article: Supplementary Figure 7 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Supplementary Figure 7 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
PDF file - 106K, Supplementary Figure 7: CSF-1R expression and breast cancer survival.
View article: Supplementary Figure 1 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Supplementary Figure 1 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
PDF file - 1316K, Supplementary Figure 1: Flow cytometric analysis of neutrophils and macrophage sub-populations.
View article: Supplementary Figure 2 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Supplementary Figure 2 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
PDF file - 406K, Supplementary Figure 2: Changes in Ly6Chi monocytes are lost when assessing FACS percentages when compared to total cell counts.
View article: Supplementary Figure 2 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Supplementary Figure 2 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
PDF file - 406K, Supplementary Figure 2: Changes in Ly6Chi monocytes are lost when assessing FACS percentages when compared to total cell counts.
View article: Data from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Data from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
Treatment options are limited for patients with breast cancer presenting with metastatic disease. Targeting of tumor-associated macrophages through the inhibition of colony-stimulating factor-1 receptor (CSF-1R), a key macrophage signaling…
View article: Supplementary Figure 1 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Supplementary Figure 1 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
PDF file - 1316K, Supplementary Figure 1: Flow cytometric analysis of neutrophils and macrophage sub-populations.
View article: Supplementary Figure 3 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Supplementary Figure 3 from The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor Open
PDF file - 56K, Supplementary Figure 3: Images of lungs from mice bearing 4T1.2 or 67NR tumors.
View article: <scp>CCL17</scp>/<scp>TARC</scp> in autoimmunity and inflammation—not just a T‐cell chemokine
<span>CCL17</span>/<span>TARC</span> in autoimmunity and inflammation—not just a T‐cell chemokine Open
Chemokine (C–C) ligand 17 (CCL17) was first identified as thymus‐ and activation‐regulated chemokine when it was found to be constitutively expressed in the thymus and identified as a T‐cell chemokine. This chemoattractant molecule has sub…
View article: 2305 Glioblastoma – inhibition of P2X7R as a potential therapeutic target for treatment of this aggressive cancer
2305 Glioblastoma – inhibition of P2X7R as a potential therapeutic target for treatment of this aggressive cancer Open
Introduction The most common and most lethal form of primary brain cancer is glioblastoma. With current treatments, prognosis of patients with glioblastoma remains poor: average survival of 10–18 months. P2X7R is a purinergic receptor and …
View article: Poster 108: Narcotic Use Following Knee Arthroscopy in Adolescent Patients: A Prospective Evaluation
Poster 108: Narcotic Use Following Knee Arthroscopy in Adolescent Patients: A Prospective Evaluation Open
Objectives: The practice of prescribing opioid medication prescribing has been at the forefront of national attention due to the opioid epidemic that affects the United States. 1,2 Over-prescribing of opioid medication has led to non-medic…
View article: Lunar Science, Resources and Innovation at Field Simulations
Lunar Science, Resources and Innovation at Field Simulations Open
Hawai`i Island has had a pivotal role in human Lunar Exploration by virtue of its high-fidelity science and technical field sites.  The geologic and historically recent volcanic landscape along with the geochemical simularity of Hawai…
View article: <p>GM-CSF: A Promising Target in Inflammation and Autoimmunity</p>
GM-CSF: A Promising Target in Inflammation and Autoimmunity Open
The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro the proliferation and differentiation of bone marrow progenitors into granulocytes and macrophages. Much precl…
View article: GM-CSF: A Promising Target in Inflammation and Autoimmunity
GM-CSF: A Promising Target in Inflammation and Autoimmunity Open
Kevin MC Lee,1 Adrian A Achuthan,1 John A Hamilton1,2 1Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, 3050, Australia; 2Australian Institute for Musculoskeletal Science (AIMSS), The Universit…
View article: Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells
Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells Open
Glioblastoma is the most aggressive form of primary brain cancer, with a median survival of 12–15 months. The P2X receptor 7 (P2X7R) is upregulated in glioblastoma and is associated with increased tumor cell proliferation. The cytokine gra…