John A. Jane
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View article: A Silent Threat in Post-Tuberculosis Patients: Chronic Pulmonary Aspergillosis Survey in Multiple Regions of Indonesia (I-CHROME Study)
A Silent Threat in Post-Tuberculosis Patients: Chronic Pulmonary Aspergillosis Survey in Multiple Regions of Indonesia (I-CHROME Study) Open
Background: A significant complication among post-tuberculosis patients is chronic pulmonary aspergillosis (CPA), with prevalence and outcomes varying by region. This study aimed to explore the epidemiology, clinical characteristics, and m…
View article: Risk of new tumor, carotid stenosis, and stroke after stereotactic radiosurgery for pituitary tumor: A multicenter study of 2254 patients with imaging follow-up
Risk of new tumor, carotid stenosis, and stroke after stereotactic radiosurgery for pituitary tumor: A multicenter study of 2254 patients with imaging follow-up Open
Background A higher risk of secondary brain tumor, carotid stenosis, and stroke has been reported after conventional sella irradiation for pituitary neuroendocrine tumors (PitNET). Stereotactic radiosurgery (SRS), which is a more focused a…
Prognostic Factors and Nomogram for Choroid Plexus Tumors: A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis Open
Background: Choroid plexus tumors (CPTs) are rare neoplasms found in the central nervous system, comprising 1% of all brain tumors. These tumors include choroid plexus papilloma (CPP), atypical choroid plexus papilloma (aCPP), and choroid …
Nontraumatic symptomatic de novo arachnoid cyst in an adolescent patient treated with cystoperitoneal shunting: illustrative case Open
BACKGROUND Arachnoid cysts are often congenital, asymptomatic lesions detected in the pediatric population. When seen in adults, they usually occur following trauma. De novo formation of arachnoid cysts is uncommon, with only a few instanc…
Co-occurrence of Functional Gonadotroph Adenoma and Lactotroph Adenoma: A Case Report and Literature Review Open
In patients who present with elevated gonadotropin levels despite hyperprolactinemia, we suggest considering FGA. Further research is needed to clarify whether there is underdiagnosis of lactotroph adenomas co-occurring with gonadotroph ad…
View article: QLTI-09. DEFINING GLOBAL BENCHMARK OUTCOMES FOR TRANSSPHENOIDAL SURGERY OF PITUITARY ADENOMAS: A MULTICENTER ANALYSIS OF 2862 CASES
QLTI-09. DEFINING GLOBAL BENCHMARK OUTCOMES FOR TRANSSPHENOIDAL SURGERY OF PITUITARY ADENOMAS: A MULTICENTER ANALYSIS OF 2862 CASES Open
Benchmarks are important to measure and aid in improve outcomes for surgical procedures. However, best achievable results that have been validated internationally for transsphenoidal surgery are not available. Therefore, we aimed to establ…
View article: Effect of Distance from Target on Hypopituitarism After Stereotactic Radiosurgery for Pituitary Adenomas
Effect of Distance from Target on Hypopituitarism After Stereotactic Radiosurgery for Pituitary Adenomas Open
IntroductionDelayed hypopituitarism is the most common complication after stereotactic radiosurgery (SRS) for pituitary adenomas. The aim of this study was to investigate the relationship between the distance from the hypothalamic-pituitar…
Radiological and clinical outcomes of pituitary apoplexy: comparison of conservative management versus early surgical intervention Open
OBJECTIVE Early surgical intervention for patients with pituitary apoplexy (PA) is thought to improve visual outcomes and decrease mortality. However, some patients may have good clinical outcomes without surgery. The authors sought to com…
Editorial. Craniopharyngioma classification Open
Craniopharyngiomas (CPs) are among the most surgically complex brain tumors due to their deep location and intimate involvement with critical neural and vascular structures.Furthermore, injury to the adjacent hypothalamus, infundibulum, pi…
Giant pituitary macroadenoma of stem cell origin: illustrative case Open
BACKGROUND Giant pituitary macroadenomas with a diameter >4 cm are rare tumors, accounting for only about 5% of pituitary adenomas. They are more difficult to maximally resect safely owing to limited access as well as encasement of adjacen…
Gender-Pay Equity in Academic Neurosurgery at United States Public Universities Open
Background Compensation has historically been unequal for men versus women in medical fields, particularly in surgical subspecialties. Objective We analyzed associations between gender and compensation and identified factors associated wit…
Genomic and molecular characterization of pituitary adenoma pathogenesis: review and translational opportunities Open
OBJECTIVE Innovations in genomics, epigenomics, and transcriptomics now lay the groundwork for therapeutic interventions against neoplastic disease. In the past 30 years, the molecular pathogenesis of pituitary adenomas has been characteri…
From Bench to Bedside, the Current State of Oncolytic Virotherapy in Pediatric Glioma Open
Glioma continues to be a challenging disease process, making up the most common tumor type within the pediatric population. While low-grade gliomas are typically amenable to surgical resection, higher grade gliomas often require additional…
Endoscopic endonasal surgery outcomes for pediatric craniopharyngioma: a systematic review Open
OBJECTIVE The goal of this study was to systematically review the outcomes of endoscopic endonasal surgery (EES) for pediatric craniopharyngiomas so as to assess its safety and efficacy. METHODS A systematic literature review was performed…
S7A-11 SESSION 7A: SAGITTAL SYNOSTOSIS EVOLUTION OF SURGICAL MANAGEMENT OF SAGITTAL SYNOSTOSIS – A SINGLE INSTITUTION REVIEW Open
Introduction: Craniosynostosis occurs in approximately 1 in 2000 live births with sagittal synostosis representing the most common type. Many methods for surgical correction have been described with similar outcomes. At our institution, nu…
A modern series of subdiaphragmatic craniopharyngiomas Open
OBJECTIVE The endoscopic endonasal approach has been proposed as a primary surgical strategy for select craniopharyngiomas. However, those tumors that arise from the sella have not been classified with the other craniopharyngioma subtypes …
Spindle cell oncocytoma of the pituitary gland Open
OBJECTIVE The authors report the diagnosis, management, and outcomes of 6 cases of spindle cell oncocytoma (SCO) in an effort to guide clinical diagnosis and management of these uncommon lesions. METHODS This study is a retrospective revie…
Tumor to Cerebellar Peduncle T2-Weighted Imaging Intensity Ratio Fails to Predict Pituitary Adenoma Consistency Open
Object The consistency of pituitary macroadenomas affects the complexity of surgical resection. On T2-weighted (T2W) imaging, the intensity ratio of the tumor to the cerebellar peduncle (tumor to cerebellar peduncle T2-weighted imaging int…
Severe cranial deformity following cerebrospinal fluid diversion in an adolescent with osteogenesis imperfecta Open
Osteogenesis imperfecta (OI) is an inherited connective tissue disorder that causes bone fragility and deformity. Neurological manifestations, including macrocephaly and hydrocephalus, have been reported. Increased vascular fragility or bl…
Prediction of cavernous sinus invasion in patients with Cushing’s disease by magnetic resonance imaging Open
OBJECTIVE Cavernous sinus invasion (CSI) in Cushing’s disease (CD) negatively affects the probability of complete resection, biochemical cure, and need for adjuvant therapy. However, the prediction of CSI based on MRI findings has been inc…
CRAN-16. IMPORTANCE OF SURGICAL INTERVENTION IN RECOVERY OF VISUAL FUNCTION IN A TEENAGER WITH AN ACIDOPHILIC STEM CELL ADENOMA Open
BACKGROUND: Prolactin-secreting macroadenomas are generally not life-threatening and often present with visual impairment. Medical management with a dopamine agonist is typically the treatment of choice, which significantly reduces the tum…
Presentation and outcomes in surgically and conservatively managed pediatric Rathke cleft cysts Open
OBJECTIVE Rathke cleft cysts (RCCs) are sellar lesions that are commonly encountered in adults but infrequently diagnosed in the pediatric population. As a result, the optimal management of pediatric RCCs remains a subject of controversy. …
Early versus late Gamma Knife radiosurgery following transsphenoidal surgery for nonfunctioning pituitary macroadenomas: a multicenter matched-cohort study Open
OBJECTIVE Gamma Knife radiosurgery (GKRS) is frequently used to treat residual or recurrent nonfunctioning pituitary macroadenomas. There is no consensus as to whether GKRS should be used early after surgery or if radiosurgery should be wi…
Decrease of Serum IGF-I following Transsphenoidal Pituitary Surgery for Acromegaly Open
BACKGROUND In the immediate postoperative period following resection of growth hormone (GH)-secreting pituitary tumors, serum concentrations of GH have limited ability to predict remission of acromegaly. Since many actions of GH actions ar…
View article: Abstract: Impact of Age at Whole-Vault Cranioplasty and Reoperation on Long-Term Neurocognitive Outcomes in Sagittal Craniosynostosis
Abstract: Impact of Age at Whole-Vault Cranioplasty and Reoperation on Long-Term Neurocognitive Outcomes in Sagittal Craniosynostosis Open
PURPOSE: Neurocognitive studies in school-age children with craniosynostosis reveal lower scores compared to controls. Optimal age at surgery in craniosynostosis continues to be debated. In addition, individuals with craniosynostosis may u…
Physiological growth hormone replacement and rate of recurrence of craniopharyngioma: the Genentech National Cooperative Growth Study Open
OBJECTIVE The object of this study was to establish recurrence rates in patients with craniopharyngioma postoperatively treated with recombinant human growth hormone (rhGH) as a basis for determining the risk of rhGH therapy in the develop…