John A. Jansen
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View article: The Current State and Future of Oral Health: A Position Paper Exploring the Role of Regenerative Dentistry
The Current State and Future of Oral Health: A Position Paper Exploring the Role of Regenerative Dentistry Open
Review The Current State and Future of Oral Health: A Position Paper Exploring the Role of Regenerative Dentistry John A. Jansen Department of Dentistry-Regenerative Biomaterials, Radboud University Medical Center, P.O. Box 9101, 6500 HB N…
View article: Compositional Variations in Calcium Phosphate Cement and Poly(Lactic‐Co‐Glycolic‐Acid) Porogens Do Not Affect the Orthotopic Performance of Calcium Phosphate Cement/Poly(Lactic‐Co‐Glycolic‐Acid) Cements
Compositional Variations in Calcium Phosphate Cement and Poly(Lactic‐Co‐Glycolic‐Acid) Porogens Do Not Affect the Orthotopic Performance of Calcium Phosphate Cement/Poly(Lactic‐Co‐Glycolic‐Acid) Cements Open
Calcium phosphate cement (CPC) has evolved as an appealing bone substitute material, especially since CPCs were combined with poly(lactic‐co‐glycolic acid) (PLGA) porogens to render the resulting CPC/PLGA composite degradable. In view of t…
View article: Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia
Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia Open
Clozapine is the only licensed medication for treatment-resistant schizophrenia (TRS). Few predictors for variation in response to clozapine have been identified, but clozapine metabolism is known to influence therapeutic response and adve…
View article: Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count
Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count Open
Clozapine is effective at reducing symptoms of treatment-resistant schizophrenia, but it can also induce several adverse outcomes including neutropenia and agranulocytosis. We used linear mixed-effect models and structural equation modelli…
View article: Mediation and Longitudinal Analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count
Mediation and Longitudinal Analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count Open
Clozapine is effective at reducing symptoms of treatment-resistant schizophrenia, but it can also induce several adverse outcomes including neutropenia and agranulocytosis. We used linear mixed-effect models and structural equation modelli…
View article: Influence of bisphosphonate treatment on bone substitute performance in osteoporotic conditions
Influence of bisphosphonate treatment on bone substitute performance in osteoporotic conditions Open
Objective Considering the elevated number of osteoporotic patients in need of bone graft procedures, we here evaluated the effect of alendronate (ALN) treatment on the regeneration of bone defects in osteoporotic rats. Bone formation was h…
View article: Lateral Bone Augmentation Using a Three-Dimensional-Printed Polymeric Chamber to Compare Biomaterials
Lateral Bone Augmentation Using a Three-Dimensional-Printed Polymeric Chamber to Compare Biomaterials Open
The aim of this study was to test the suitability of calcium phosphate cement mixed with poly(lactic-co-glycolic acid) (CPC-PLGA) microparticles into a ring-shaped polymeric space-maintaining device as bone graft material for lateral bone …
View article: Tunable calcium phosphate cement formulations for predictable local release of doxycycline
Tunable calcium phosphate cement formulations for predictable local release of doxycycline Open
Background Osteomyelitis is a bacterial infection, which leads to bone loss. Local treatment focuses on elimination of bacteria, which is preferable for simultaneous management of the bone defect after sequestrectomy and bone reconstructio…
View article: A histological evaluation of cellular response on bone regeneration scaffold
A histological evaluation of cellular response on bone regeneration scaffold Open
Biocompatibility testing for a new implant material is necessary before clinical use. The materials for bone scaffolding must also go through biocompatibility tests both in vitro and in vivo. The purpose of this study was to compare differ…
View article: Rare Variants in Pharmacogenes Influence Clozapine Metabolism in Individuals with Schizophrenia
Rare Variants in Pharmacogenes Influence Clozapine Metabolism in Individuals with Schizophrenia Open
Clozapine is the only licensed medication for treatment-resistant schizophrenia (TRS). Few predictors for variation in response to clozapine have been identified, but clozapine metabolism is known to influence therapeutic response and the …
View article: Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model
Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model Open
Polyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings. These gels are thermo-sensitive, allow application as a cold liquid, and rely on gelation through body heat. It is supposed that the gel can be easily removed b…
View article: Repair of complex ovine segmental mandibulectomy utilizing customized tissue engineered bony flaps
Repair of complex ovine segmental mandibulectomy utilizing customized tissue engineered bony flaps Open
Craniofacial defects require a treatment approach that provides both robust tissues to withstand the forces of mastication and high geometric fidelity that allows restoration of facial architecture. When the surrounding soft tissue is comp…
View article: Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring data
Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring data Open
UK Academy of Medical Sciences, UK Medical Research Council, and European Commission.
View article: Fast Degradable Calcium Phosphate Cement for Maxillofacial Bone Regeneration
Fast Degradable Calcium Phosphate Cement for Maxillofacial Bone Regeneration Open
The aim of this preclinical study was to test the applicability of calcium phosphate cement (CPC)-poly(lactic-co-glycolic acid) (PLGA)-carboxymethylcellulose (CMC) as a bone substitute material for guided bone regeneration (GBR) procedures…
View article: Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: A longitudinal analysis and GWAS using clinical monitoring data from the UK
Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: A longitudinal analysis and GWAS using clinical monitoring data from the UK Open
Background The antipsychotic clozapine is the only drug with proven effectiveness against the treatment-resistant symptoms that affect 20-30% of those with schizophrenia. Despite this, clozapine is markedly under-prescribed, partly due to …
View article: Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores
Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores Open
BACKGROUND Treatment-resistant schizophrenia (TRS) affects ∼30% of individuals with the disorder. Clozapine is the medication of choice in TRS but optimizing administration and dose titration are complex. The identification of predictive f…
View article: Histological evaluation of titanium fiber mesh-coated implants in a rabbit femoral condyle model
Histological evaluation of titanium fiber mesh-coated implants in a rabbit femoral condyle model Open
This in vivo study demonstrated that implants with a flexible coating of TFM improve bone formation within the inter-fiber space and the peri-implant region.
View article: Comment on esurf-2021-54
Comment on esurf-2021-54 Open
In steep landscapes, river incision sets the pace of landscape evolution. Transport of coarse sediment controls incision by evacuating material delivered to river channels by landslides. However, large landslide-derived boulders that imped…
View article: Innovative implant design for continuous implant stability: A mechanical and histological experimental study in the iliac crest of goats
Innovative implant design for continuous implant stability: A mechanical and histological experimental study in the iliac crest of goats Open
It is a challenge to optimize implants with continuous primary stability and rapid transition into secondary stability to minimize the duration of the lag-phase. The results of this study prove the absence of a lag-phase in implant stabili…
View article: Comment on esurf-2021-7
Comment on esurf-2021-7 Open
Abstract. Erosion is directly tied to landscape evolution through the relationship between sediment flux and vertical lowering of the land surface. Therefore, the analysis of erosion rates across the planet measured over different temporal…
View article: Regenerating Critical Size Rat Segmental Bone Defects with a Self‐Healing Hybrid Nanocomposite Hydrogel: Effect of Bone Condition and BMP‐2 Incorporation
Regenerating Critical Size Rat Segmental Bone Defects with a Self‐Healing Hybrid Nanocomposite Hydrogel: Effect of Bone Condition and BMP‐2 Incorporation Open
The aim of the current study is to assess the biological performance of self‐healing hydrogels based on calcium phosphate (CaP) nanoparticles and bisphosphonate (BP) conjugated hyaluronan (HA) in a critical size segmental femoral bone defe…
View article: Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia
Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia Open
Up to one-third of those with schizophrenia fail to respond to standard antipsychotics and are considered to have treatment-resistant schizophrenia, a condition for which clozapine is the only evidence-based medication. While up to 60% of …
View article: Effect of Systemic Zoledronic Acid Dosing Regimens on Bone Regeneration in Osteoporotic Rats
Effect of Systemic Zoledronic Acid Dosing Regimens on Bone Regeneration in Osteoporotic Rats Open
The aim of this study was to evaluate the regeneration of bone defects created in the femoral condyle of osteoporotic rats, following intravenous (IV) zoledronate (ZA) treatment in three settings: pre-bone grafting (ZA-Pre), post-bone graf…