John A. Todd
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View article: Improving population-scale disease prediction through multi-omics integration
Improving population-scale disease prediction through multi-omics integration Open
The early detection of common diseases is currently constrained by a dependence on single biomarkers, which often capture only a limited aspect of disease pathology. Here, we applied multi-omic factor analysis to integrate plasma proteins,…
View article: Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial
Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial Open
Leona M and Harry B Helmsley Charitable Trust.
View article: Identification of novel type 1 and type 2 diabetes genes by co-localization of human islet eQTL and GWAS variants with colocRedRibbon
Identification of novel type 1 and type 2 diabetes genes by co-localization of human islet eQTL and GWAS variants with colocRedRibbon Open
Over 1,000 genetic variants have been associated with diabetes by genome-wide association studies (GWASs), but for most, their functional impact is unknown; only 7% alter gene expression in pancreatic islets in expression quantitative trai…
View article: Epigenetic differences at immune and type 1 diabetes susceptibility genes in blood from young children after COVID-19 infection
Epigenetic differences at immune and type 1 diabetes susceptibility genes in blood from young children after COVID-19 infection Open
Children with SARS-CoV-2 infection showed sustained DNA methylation changes at genes critical for antiviral response and T1D susceptibility, potentially contributing to immune dysregulation and promotion of the autoimmune process underlyin…
View article: A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics
A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics Open
Physiological changes during pregnancy support foetal growth, including adaptations in pancreatic islets to maintain glucose homeostasis. We investigate these adaptations using rare, high-quality pancreatic tissue from pregnant human donor…
View article: Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections Open
View article: Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease
Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease Open
View article: Exploring Young Trans and Non-binary People’s Strategies and Spaces for Navigating Marginality in the United Kingdom: A Novel Resilience, Resistance, and Restoration Framework
Exploring Young Trans and Non-binary People’s Strategies and Spaces for Navigating Marginality in the United Kingdom: A Novel Resilience, Resistance, and Restoration Framework Open
Amid recent, unprecedented sociopolitical scrutiny and hypervisibility of young trans people in the United Kingdom, this article considers how trans youth develop individual and collective mechanisms, spaces, and embodied practices of resi…
View article: Type 1 Diabetes Genetics Consortium
Type 1 Diabetes Genetics Consortium Open
Type 1 diabetes (T1D) results from the autoimmune destruction of the insulin-producing β cells. Genetic factors account for approximately 50% of the risk for T1D but, by the late 1990s, the genetic basis was limited. The Type 1 Diabetes Ge…
View article: Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow‐Up Studies
Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow‐Up Studies Open
Biological datasets often consist of thousands or millions of variables, e.g. genetic variants or biomarkers, and when sample sizes are large it is common to find many associated with an outcome of interest, for example, disease risk in a …
View article: Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells
Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells Open
Insulin secretion increases progressively during pregnancy to maintain normal maternal blood glucose levels. The placenta plays a crucial role in this process by releasing hormones and extracellular vesicles into the maternal circulation, …
View article: Identification of novel type 1 and type 2 diabetes genes by co-localization of human islet eQTL and GWAS variants with colocRedRibbon
Identification of novel type 1 and type 2 diabetes genes by co-localization of human islet eQTL and GWAS variants with colocRedRibbon Open
Over 1,000 distinct genetic variants have been associated with diabetes risk by genome-wide association studies (GWAS) but for most their functional impact is unknown and less than 15% of the diabetes GWAS variants have been shown in expre…
View article: A study to determine a capillary alternative to the gold standard oral glucose tolerance test - Protocol
A study to determine a capillary alternative to the gold standard oral glucose tolerance test - Protocol Open
Type 1 diabetes (T1D) is a chronic condition caused by the immune destruction of the pancreatic beta cells. T1D has recognised asymptomatic pre-clinical stages, providing an opportunity for early diagnosis, education and treatment which ma…
View article: The recombinant shingles vaccine is associated with lower risk of dementia
The recombinant shingles vaccine is associated with lower risk of dementia Open
There is emerging evidence that the live herpes zoster (shingles) vaccine might protect against dementia. However, the existing data are limited and refer only to the live vaccine, which is now discontinued in the United States and many ot…
View article: General population screening for type 1 diabetes using islet autoantibodies at the preschool vaccination visit: a proof-of-concept study (the T1Early study)
General population screening for type 1 diabetes using islet autoantibodies at the preschool vaccination visit: a proof-of-concept study (the T1Early study) Open
Objective Type 1 diabetes (T1D) screening programmes testing islet autoantibodies (IAbs) in childhood can reduce life-threatening diabetic ketoacidosis. General population screening is required to detect the majority of children with T1D, …
View article: Effect of 48 Months of Closed-Loop Insulin Delivery on Residual C-Peptide Secretion and Glycemic Control in Newly Diagnosed Youth With Type 1 Diabetes: A Randomized Trial
Effect of 48 Months of Closed-Loop Insulin Delivery on Residual C-Peptide Secretion and Glycemic Control in Newly Diagnosed Youth With Type 1 Diabetes: A Randomized Trial Open
OBJECTIVE We evaluated the effect of long-term intensive metabolic control with hybrid closed-loop (CL) on residual C-peptide secretion and glucose control compared with standard insulin therapy in youth with type 1 diabetes over 48 months…
View article: Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry Open
View article: The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults
The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults Open
View article: Tau depletion in human neurons mitigates Aβ-driven toxicity
Tau depletion in human neurons mitigates Aβ-driven toxicity Open
Alzheimer’s disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological accumulation of extracellular plaques and intracellular neurofibrillary tangles that mainly consist …
View article: Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes
Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes Open
View article: Vitamin D insufficiency in infants with increased risk of developing type 1 diabetes: a secondary analysis of the POInT Study
Vitamin D insufficiency in infants with increased risk of developing type 1 diabetes: a secondary analysis of the POInT Study Open
Background Vitamin D insufficiency (VDI) may be a factor in the development of type 1 diabetes (T1D). The aim of this study is to investigate the presence and persistence of VDI in a large cohort of infants with increased risk of developin…
View article: Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetes
Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetes Open
Objective: C-peptide and islet autoantibodies are key type 1 diabetes biomarkers, typically requiring venous sampling, which limit their utility. We assessed transdermal capillary blood (TCB) collection as a practical alternative.Research …
View article: Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetes
Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetes Open
Objective: C-peptide and islet autoantibodies are key type 1 diabetes biomarkers, typically requiring venous sampling, which limit their utility. We assessed transdermal capillary blood (TCB) collection as a practical alternative.Research …
View article: Transdermal Blood Sampling for C-Peptide Is a Minimally Invasive, Reliable Alternative to Venous Sampling in Children and Adults With Type 1 Diabetes
Transdermal Blood Sampling for C-Peptide Is a Minimally Invasive, Reliable Alternative to Venous Sampling in Children and Adults With Type 1 Diabetes Open
OBJECTIVE C-peptide and islet autoantibodies are key type 1 diabetes biomarkers, typically requiring venous sampling, which limits their utility. We assessed transdermal capillary blood (TCB) collection as a practical alternative. RESEARCH…
View article: General population screening for type 1 diabetes using islet autoantibodies at the preschool vaccination visit: a proof-of-concept study (the T1Early study)
General population screening for type 1 diabetes using islet autoantibodies at the preschool vaccination visit: a proof-of-concept study (the T1Early study) Open
Objective Type 1 diabetes (T1D) screening programmes testing islet autoantibodies (IAbs) in childhood can reduce life-threatening diabetic ketoacidosis. General population screening is required to detect the majority of children with T1D, …
View article: SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile
SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile Open
View article: SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood Open
Importance The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etio…
View article: Issue Information
Issue Information Open
aims and scope Parasite Immunology is an international journal devoted to research on all aspects of parasite immunology in human and animal hosts.Emphasis has been placed on how hosts control parasites, and the immunopathological reaction…
View article: Gene expression signature predicts rate of type 1 diabetes progression
Gene expression signature predicts rate of type 1 diabetes progression Open
View article: Issue Information
Issue Information Open
aims and scope Parasite Immunology is an international journal devoted to research on all aspects of parasite immunology in human and animal hosts.Emphasis has been placed on how hosts control parasites, and the immunopathological reaction…