John Abelson
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View article: Single Molecule Cluster Analysis dissects splicing pathway conformational dynamics
Single Molecule Cluster Analysis dissects splicing pathway conformational dynamics Open
The spliceosome is the dynamic RNA-protein machine responsible for faithfully splicing introns from precursor messenger RNAs (pre-mRNAs). Many of the dynamic processes required for the proper assembly, catalytic activation, and disassembly…
View article: A close-up look at the spliceosome, at last
A close-up look at the spliceosome, at last Open
Major developments in cryo-electron microscopy in the past three or four years have led to the solution of a number of spliceosome structures at high resolution, e.g., the fully assembled but not yet active spliceosome (Bact), the spliceos…