John B. Chambers
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View article: Management of Echocardiography Requests for the Detection and Follow‐Up of Heart Valve Disease: A Consensus Statement From the British Heart Valve Society
Management of Echocardiography Requests for the Detection and Follow‐Up of Heart Valve Disease: A Consensus Statement From the British Heart Valve Society Open
Background In the aftermath of the Covid19 pandemic and lockdowns, there has been a growing population awaiting transthoracic echocardiograms for potential valvular heart disease. Conducting comprehensive echocardiograms for all individual…
View article: Llettuce: An Open Source Natural Language Processing Tool for the Translation of Medical Terms into Uniform Clinical Encoding
Llettuce: An Open Source Natural Language Processing Tool for the Translation of Medical Terms into Uniform Clinical Encoding Open
This paper introduces Llettuce, an open-source tool designed to address the complexities of converting medical terms into OMOP standard concepts. Unlike existing solutions such as the Athena database search and Usagi, which struggle with s…
View article: Antithrombotic therapy after heart valve surgery: contemporary practice in the UK
Antithrombotic therapy after heart valve surgery: contemporary practice in the UK Open
OBJECTIVES There is a lack of high-quality data informing the optimal antithrombotic drug strategy following bioprosthetic heart valve replacement or valve repair. Disparity in recommendations from international guidelines reflects this. T…
View article: Impact of gender, ethnicity and social deprivation on access to surgical or transcatheter aortic valve replacement in aortic stenosis: a retrospective database study in England
Impact of gender, ethnicity and social deprivation on access to surgical or transcatheter aortic valve replacement in aortic stenosis: a retrospective database study in England Open
Objective To assess gender, ethnicity, and deprivation-based differences in provision of aortic valve replacement (AVR) in England for adults with aortic stenosis (AS). Methods We retrospectively identified adults with AS from the English …
View article: Expert consensus recommendations for the provision of infective endocarditis services: updated guidance from the Joint British Societies
Expert consensus recommendations for the provision of infective endocarditis services: updated guidance from the Joint British Societies Open
Infective endocarditis (IE) remains a difficult condition to diagnose and treat and is an infection of high consequence for patients, causing long hospital stays, life-changing complications and high mortality. A new multidisciplinary, mul…
View article: Antithrombotic Therapy After Heart Valve Surgery, Contemporary Practice in the United Kingdom
Antithrombotic Therapy After Heart Valve Surgery, Contemporary Practice in the United Kingdom Open
Objectives There is a lack of high-quality data informing the optimal antithrombotic drug strategy following bioprosthetic heart valve replacement or valve repair. Disparity in recommendations from international guidelines reflects this. T…
View article: European survey on valvular heart disease clinical experience from the European Society of Cardiology council on valvular heart disease
European survey on valvular heart disease clinical experience from the European Society of Cardiology council on valvular heart disease Open
Aims The aim of this survey is to analyze how current recommendations on valvular heart disease (VHD) management have been adopted. Identifying potential discrepancies between recommendations and everyday clinical practice would enable us …
View article: Exercise Testing in Aortic Stenosis: Safety, Tolerability, Clinical Benefits and Prognostic Value
Exercise Testing in Aortic Stenosis: Safety, Tolerability, Clinical Benefits and Prognostic Value Open
Background: Routine exercise testing in asymptomatic patients with valvular heart disease (VHD) better classifies the hemodynamic severity of valve stenosis or regurgitation, and describes the symptomatic status and functional capacity of …
View article: Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement
Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement Open
Bioprosthetic valve dysfunction (BVD) and bioprosthetic valve failure (BVF) may be caused by structural or nonstructural valve dysfunction. Both surgical and transcatheter bioprosthetic valves have limited durability because of structural …
View article: Clinical significance and prognostic value of ST segment depression on ECG during exercise treadmill test in asymptomatic patients with moderate or severe aortic stenosis
Clinical significance and prognostic value of ST segment depression on ECG during exercise treadmill test in asymptomatic patients with moderate or severe aortic stenosis Open
Objectives. In patients with asymptomatic moderate or severe aortic stenosis (AS), exercise testing is used for evaluating the need for aortic valve intervention. Expert opinions about the clinical significance and prognostic value of ST s…
View article: Shared Decision-Making and Patient-Reported Outcome Measures in Valvular Heart Disease
Shared Decision-Making and Patient-Reported Outcome Measures in Valvular Heart Disease Open
Patient-centered health care emphasizes shared decision-making (SDM), incorporating both clinical evidence and patient preferences and values. SDM is important in heart valve disease, both because there might be more than one treatment opt…
View article: Echocardiographic features of left ventricular recess, cleft, diverticulum, and aneurysm: A systematic review
Echocardiographic features of left ventricular recess, cleft, diverticulum, and aneurysm: A systematic review Open
A pouch protruding into the wall of the left ventricle (LV) may be either a recess, cleft, diverticulum, or aneurysm. Being aware of these anomalies is essential to make accurate diagnosis and guide management decisions. Standard multimoda…
View article: Multi-modality imaging assessment of native valvular regurgitation: an EACVI and ESC council of valvular heart disease position paper
Multi-modality imaging assessment of native valvular regurgitation: an EACVI and ESC council of valvular heart disease position paper Open
Valvular regurgitation represents an important cause of cardiovascular morbidity and mortality. Imaging is pivotal in the evaluation of native valve regurgitation and echocardiography is the primary imaging modality for this purpose. The i…
View article: Left atrial volume index predicts adverse events in asymptomatic moderate or severe aortic stenosis
Left atrial volume index predicts adverse events in asymptomatic moderate or severe aortic stenosis Open
Objective In aortic stenosis (AS), chronic pressure overload on left ventricle (LV) leads to LV hypertrophy, impaired relaxation, increased chamber stiffness, fibrosis and left atrial (LA) dilatation. An enlarged LA may be a marker of long…
View article: Automated left ventricular dimension assessment using artificial intelligence
Automated left ventricular dimension assessment using artificial intelligence Open
Background and purpose Artificial intelligence (AI) has the potential to greatly improve efficiency and reproducibility of quantification in echocardiography, but to gain widespread use it must both meet expert standards of excellence and …
View article: First phase ejection fraction in aortic stenosis: A useful new measure of early left ventricular systolic dysfunction
First phase ejection fraction in aortic stenosis: A useful new measure of early left ventricular systolic dysfunction Open
In aortic stenosis (AS), a left ventricular (LV) ejection fraction (EF) <50% or symptoms are class I indications for aortic valve intervention. However, an EF <50% may be too conservative since subendocardial fibrosis may already have deve…
View article: Automated Left Ventricular Dimension Assessment Using Artificial Intelligence Developed and Validated by a UK-Wide Collaborative
Automated Left Ventricular Dimension Assessment Using Artificial Intelligence Developed and Validated by a UK-Wide Collaborative Open
Background: Artificial intelligence (AI) for echocardiography requires training and validation to standards expected of humans. We developed an online platform and established the Unity Collaborative to build a dataset of expertise from 17…
View article: First-phase ejection fraction by cardiovascular magnetic resonance predicts outcomes in aortic stenosis
First-phase ejection fraction by cardiovascular magnetic resonance predicts outcomes in aortic stenosis Open
EF1 is a simple robust marker of early left ventricular impairment that can be precisely measured by CMR and predicts outcome in aortic stenosis. Its measurement by CMR is more reproducible than that by TTE and may facilitate left ventricu…
View article: First phase ejection fraction in aortic stenosis; a useful new measure of early left ventricular systolic dysfunction
First phase ejection fraction in aortic stenosis; a useful new measure of early left ventricular systolic dysfunction Open
In aortic stenosis (AS), a left ventricular (LV) ejection fraction (EF) <50% or symptoms are class I indications for aortic valve intervention. However, an EF <50% may be too conservative since subendocardial fibrosis may already have deve…
View article: Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene
Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene Open
Calcium has a pivotal role in biological functions, and serum calcium levels have been associated with numerous disorders of bone and mineral metabolism, as well as with cardiovascular mortality. Here we report results from a genome-wide a…
View article: Biological, clinical and population relevance of 95 loci for blood lipids
Biological, clinical and population relevance of 95 loci for blood lipids Open
Serum concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are among the most important risk factors for coronary artery disease (CAD) and ar…
View article: Higher acceleration ejection time ratio predicts impaired prognosis in mild to moderate aortic stenosis
Higher acceleration ejection time ratio predicts impaired prognosis in mild to moderate aortic stenosis Open
Introduction Acceleration/ejection time (AT/ET) ratio is a marker of aortic stenosis (AS) severity, and a predictor of outcome in severe AS. The importance of ejection dynamics in mild and moderate AS has been less investigated. Purpose To…