John B. Finlay
YOU?
Author Swipe
View article: Analysis of mucosal immune dysregulation and safety and tolerability of endoscopic topical steroid therapy for long-COVID hyposmia: randomized, double-blinded pilot study
Analysis of mucosal immune dysregulation and safety and tolerability of endoscopic topical steroid therapy for long-COVID hyposmia: randomized, double-blinded pilot study Open
NIH DC020172, American Academy of Otolaryngology-Head and Neck Surgery.
View article: Olfactory biopsy analysis of Alzheimer’s pathobiology across disease stages
Olfactory biopsy analysis of Alzheimer’s pathobiology across disease stages Open
Alzheimer’s Disease (AD) is a neurodegenerative condition affecting millions worldwide. Defining early pathobiological events remains challenging, in part due to inaccessibility of neural tissue. Because olfactory neurons are accessible, a…
View article: IMMU-81. Glioblastoma and other intracranial pathologies elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses
IMMU-81. Glioblastoma and other intracranial pathologies elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses Open
Immunotherapies remain largely ineffective against intracranial malignancies such as glioblastoma (GBM), in part due to profound systemic and local immune dysfunction. Hallmarks of systemic immune dysfunction include bone marrow T cell seq…
View article: Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion Open
Whereas terminally exhausted T (Tex_term) cells retain anti-tumor cytotoxic functions, the frequencies of stem-like progenitor-exhausted T (Tex_prog) cells better reflect immunotherapeutic responsivity. Here, we examined the intratumoral c…
View article: Olfactory neuroblastoma
Olfactory neuroblastoma Open
Originating from the olfactory neuroepithelium, olfactory neuroblastoma is a rare malignant tumor of the nasal cavity that typically affects adults between the ages of 35 and 70. Clinical presentation predominantly consists of nonspecific …
View article: IMMU-09. REVERSING SYSTEMIC T CELL DYSFUNCTION TO LICENSE IMMUNOTHERAPY IN INTRACRANIAL TUMORS
IMMU-09. REVERSING SYSTEMIC T CELL DYSFUNCTION TO LICENSE IMMUNOTHERAPY IN INTRACRANIAL TUMORS Open
Intracranial tumors present unique challenges for immunotherapy. These can include both local and systemic modes of immune suppression, the mechanistic underpinnings of which are incompletely understood. Our work reveals that intracranial …
View article: IMMU-53. ANTIGEN PRESENTATION BY TUMOR-ASSOCIATED MACROPHAGES MEDIATES PROGENITOR TO TERMINAL EXHAUSTION TRANSITION IN GBM AND OTHER SOLID TUMORS
IMMU-53. ANTIGEN PRESENTATION BY TUMOR-ASSOCIATED MACROPHAGES MEDIATES PROGENITOR TO TERMINAL EXHAUSTION TRANSITION IN GBM AND OTHER SOLID TUMORS Open
While terminally exhausted T cells (Tex_term) retain important anti-tumor cytotoxic function, it is the relative preservation of renewable, stem-like progenitor exhaustion (Tex_prog) that better indicates immunotherapeutic responsivity. Al…
View article: Long‐term olfactory loss post‐COVID‐19: Pathobiology and potential therapeutic strategies
Long‐term olfactory loss post‐COVID‐19: Pathobiology and potential therapeutic strategies Open
An acute loss of smell emerged as a striking symptom present in roughly half of the people infected with the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus in the early phases of the COVID‐19 pandemic. In most COVID‐19 …
View article: Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses
Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses Open
Intracranial tumors present unique challenges for immunotherapy. These can include both local and systemic modes of immune suppression whose mechanistic underpinnings are incompletely understood. Here, we reveal that tumors harbored intrac…
View article: IMMU-49. BETA-ADRENERGIC BLOCKADE LICENSES THE USE OF IMMUNOTHERAPY IN PRIMARY AND METASTATIC BRAIN TUMORS
IMMU-49. BETA-ADRENERGIC BLOCKADE LICENSES THE USE OF IMMUNOTHERAPY IN PRIMARY AND METASTATIC BRAIN TUMORS Open
Immunotherapy is less effective against intracranial metastases compared to extracranial metastases and ineffective against primary brain tumors such as glioblastoma. Brain tumors present a unique challenge to in the context of immunothera…
View article: 891 Beta-adrenergic blockade licenses the use of immunotherapy in primary and metastatic brain tumors
891 Beta-adrenergic blockade licenses the use of immunotherapy in primary and metastatic brain tumors Open
Background Immunotherapy is less effective against intracranial metastases compared to extracranial metastases and ineffective against primary brain tumors such as glioblastoma. Brain tumors present a unique challenge to in the context of …
View article: Polycomb repressive complex 2 regulates basal cell fate during adult olfactory neurogenesis
Polycomb repressive complex 2 regulates basal cell fate during adult olfactory neurogenesis Open
Adult neurogenesis occurs in the mammalian olfactory epithelium to maintain populations of neurons that are vulnerable to injury yet essential for olfaction. Multipotent olfactory basal stem cells are activated by damage, although mechanis…
View article: Antigen presentation by tumor-associated macrophages drives tumor-infiltrating T cells from a progenitor exhaustion state to terminal exhaustion
Antigen presentation by tumor-associated macrophages drives tumor-infiltrating T cells from a progenitor exhaustion state to terminal exhaustion Open
SUMMARY Whereas terminally exhausted T (Tex_term) cells retain anti-tumor cytotoxic functions, the frequencies of stem-like progenitor exhausted T (Tex_prog) cells better reflect immunotherapeutic responsivity. Here, we examined the intrat…
View article: Safety and Feasibility of Steroid-Eluting Stent as a Bolster in Endoscopic Anterior Skull Base Reconstruction
Safety and Feasibility of Steroid-Eluting Stent as a Bolster in Endoscopic Anterior Skull Base Reconstruction Open
Background: With a rising incidence of cerebrospinal fluid (CSF) leaks, endoscopic endonasal CSF leak repair is increasingly performed. Current approaches utilize a variety of materials including free mucosal grafts and vascularized flaps,…
View article: Table S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Table S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki…
View article: Figure S4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Figure S4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Additional Kaplan-Meier survival curves based on Hyams Grade, Dulguerov T-stage, and MKI67 gene expression. Log-rank test used to determine statistical significance.
View article: Figure S3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Figure S3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.
View article: Figure S2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Figure S2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control…
View article: FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Patterns of gene expression in the normal differentiating OE. A, Trajectory UMAP depicting differentiation states across pseudotime, in seven normal olfactory mucosa biopsies scRNA-seq from Durante and colleagues, 2020 and Oliva and collea…
View article: FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Glandular and olfactory ensheathing cell markers are present in low-grade ONB and are associated with increased survival. A, UMAP visualization of non-tumor olfactory mucosa scRNA-seq data depicts the cell type–specific expression of selec…
View article: Data from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Data from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding the mechanism…
View article: Table S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Table S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki…
View article: FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Glandular and olfactory ensheathing cell markers are present in low-grade ONB and are associated with increased survival. A, UMAP visualization of non-tumor olfactory mucosa scRNA-seq data depicts the cell type–specific expression of selec…
View article: Figure S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Figure S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu…
View article: FIGURE 2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
FIGURE 2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Pseudodeconvolution of ONB bulk RNA-seq defines proportions of cell type–specific transcriptomics across low- and high-grade tumors. A, Stacked bar chart depicts predicted proportions of cell types in bulk tumors when mapped to control adu…
View article: Figure S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Figure S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu…
View article: FIGURE 4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
FIGURE 4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
PRC2 complex expression in ONB. A, PRC2 transcripts in the core complex are mostly upregulated in high-grade ONB. B, EPOP expression is significantly increased in high-grade ONB compared with low grade, with no differences between low and …
View article: FIGURE 4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
FIGURE 4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
PRC2 complex expression in ONB. A, PRC2 transcripts in the core complex are mostly upregulated in high-grade ONB. B, EPOP expression is significantly increased in high-grade ONB compared with low grade, with no differences between low and …
View article: FIGURE 1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
FIGURE 1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma Open
Schematic of the deconvolution workflow. Diagram of normal OE in the top left colored by cell identity (HBC: yellow; GBC: pink; immature OSN: blue; mature OSN: orange; Sustentacular: green; Bowman's Gland: purple; Olfactory ensheating cell…