John B. Trudeau
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View article: Corrigendum to High IFN-γ and low SLPI mark severe asthma in mice and humans
Corrigendum to High IFN-γ and low SLPI mark severe asthma in mice and humans Open
View article: Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes
Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes Open
A stable mitochondrial pool is crucial for healthy cell function and survival. Altered redox biology can adversely affect mitochondria through induction of a variety of cell death and survival pathways, yet the understanding of mitochondri…
View article: High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status
High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status Open
Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid…
View article: Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma
Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma Open
View article: PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells
PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells Open
Significance Our work identifies regulatory mechanisms between ferroptosis and autophagy. We discovered that PE-binding protein-1 (PEBP1) is pivotal for dynamic interactions between the ferroptotic cell death program and prosurvival autoph…
View article: Oxidative Stress, as Measured by Gene Expression and Airway Glutathione, Is Increased in Severe Asthma and Associated with Racial Background
Oxidative Stress, as Measured by Gene Expression and Airway Glutathione, Is Increased in Severe Asthma and Associated with Racial Background Open
View article: Mucociliary Clearance (MCC) in Mild-Asthma Without Inhaled Corticosteroid Treatment Is Inversely Proportional to Exhaled Nitric Oxide
Mucociliary Clearance (MCC) in Mild-Asthma Without Inhaled Corticosteroid Treatment Is Inversely Proportional to Exhaled Nitric Oxide Open
View article: Baseline sputum eosinophil + neutrophil subgroups’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort
Baseline sputum eosinophil + neutrophil subgroups’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort Open
View article: Age of Asthma Onset, not Severity, Predicts Environmental Allergy Clusters
Age of Asthma Onset, not Severity, Predicts Environmental Allergy Clusters Open
View article: 15-Lipoxygenase 1 in nasal polyps promotes CCL26/eotaxin 3 expression through extracellular signal-regulated kinase activation
15-Lipoxygenase 1 in nasal polyps promotes CCL26/eotaxin 3 expression through extracellular signal-regulated kinase activation Open
View article: BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications
BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications Open
Rationale: Gene expression of BAL cells, which samples the cellular milieu within the lower respiratory tract, has not been well studied in severe asthma.Objectives: To identify new biomolecular mechanisms underlying severe a…
View article: Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation
Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation Open
Although type-2-induced (T2-induced) epithelial dysfunction is likely to profoundly alter epithelial differentiation and repair in asthma, the mechanisms for these effects are poorly understood. A role for specific mucins, heavily N-glycos…
View article: Location of Pulmonary Mast Cells Predicts Asthma Outcomes
Location of Pulmonary Mast Cells Predicts Asthma Outcomes Open
View article: Dysfunctional ErbB2, an EGF receptor family member, hinders repair of airway epithelial cells from asthmatic patients
Dysfunctional ErbB2, an EGF receptor family member, hinders repair of airway epithelial cells from asthmatic patients Open
View article: IL-4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL-25 Signaling
IL-4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL-25 Signaling Open
IL-25 and IL-4 signaling in the setting of infection or allergic responses can drive Type 2 inflammation. IL-25 requires the IL-17 receptor B (IL-17Rb) to mediate signaling through nuclear factor κ B (NF-κB) transcriptional activation. Des…
View article: Airway Mast Cells on a Type-2 Inflammatory Background Confer a More Clinically Severe Asthma Phenotype Than Isolated Type-2 Inflammation
Airway Mast Cells on a Type-2 Inflammatory Background Confer a More Clinically Severe Asthma Phenotype Than Isolated Type-2 Inflammation Open
View article: Non Type-2 Severe Asthma Has Increased Bronchoalveolar Mast Cell Mediator Release and Health Care Utilization
Non Type-2 Severe Asthma Has Increased Bronchoalveolar Mast Cell Mediator Release and Health Care Utilization Open
View article: High IFN-γ and low SLPI mark severe asthma in mice and humans
High IFN-γ and low SLPI mark severe asthma in mice and humans Open
Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low doses of inhaled CS, indicating that Th2 cells, which…
View article: Brain-Derived Neurotrophic Factor Expression in Asthma. Association with Severity and Type 2 Inflammatory Processes
Brain-Derived Neurotrophic Factor Expression in Asthma. Association with Severity and Type 2 Inflammatory Processes Open
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, exists in several isoforms, which differentially impacts neuronal and immune cell survival and differentiation. The role of BDNF and its isoforms in asthma rema…
View article: IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism
IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism Open