J. Simon Bell
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View article: Identifying dementia risk profiles for targeted interventions: A latent class analysis of at‐risk middle‐aged Australians
Identifying dementia risk profiles for targeted interventions: A latent class analysis of at‐risk middle‐aged Australians Open
INTRODUCTION This study aimed to identify distinct dementia risk profiles in middle‐aged adults with two or more potential dementia risk factors, to inform targeted prevention strategies. METHODS Cross‐sectional analysis of baseline sociod…
View article: A digital health-supported community pharmacy-based lifestyle intervention program for overweight or obese adults with prediabetes, the PRediabetes Intervention, Management and Evaluation (PRIME) Program: A cluster randomized controlled trial
A digital health-supported community pharmacy-based lifestyle intervention program for overweight or obese adults with prediabetes, the PRediabetes Intervention, Management and Evaluation (PRIME) Program: A cluster randomized controlled trial Open
The intervention showed greater weight loss than the usual care, but the proportion of individuals achieving clinically meaningful weight loss (≥5 %) was not significant. PRIME program can be an important and useful tool to improve risk fa…
View article: Exploring quality improvement processes for psychotropic medication use in Australian residential aged care homes: a qualitative study
Exploring quality improvement processes for psychotropic medication use in Australian residential aged care homes: a qualitative study Open
Recent changes in policies, procedures and infrastructure have provided clearer oversight of psychotropic medication use. Individual and system approaches to psychotropic medication use in aged care have shifted. Key opportunities for impr…
View article: National Aged Care Reforms and Trends in Psychotropic Medication Use in 428 Residential Age Care Facilities, 2018-2022
National Aged Care Reforms and Trends in Psychotropic Medication Use in 428 Residential Age Care Facilities, 2018-2022 Open
Between 2018 and 2022, use of 3 psychotropic medication classes declined in Australian RAC. However, antidepressant use increased in people with dementia, potentially as a form of chemical restraint. Ongoing monitoring of the national Qual…
View article: Rapid Access Atrial Fibrillation Clinics in Australia - Modelling outcomes and cost effectiveness
Rapid Access Atrial Fibrillation Clinics in Australia - Modelling outcomes and cost effectiveness Open
Aims Stroke prevention in patients with atrial fibrillation (AF) requires both estimation of risk and the initiation of anticoagulation treatment where indicated. Rapid access atrial fibrillation (RAAF) clinics are an accepted model of mul…
View article: Risk of Infections with <scp>SGLT2</scp> Inhibitors Versus <scp>DPP4</scp> Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data
Risk of Infections with <span>SGLT2</span> Inhibitors Versus <span>DPP4</span> Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data Open
This study compared the number and cumulative dose of antibiotic dispensings among new users of sodium–glucose cotransporter‐2 (SGLT2) inhibitors and dipeptidyl peptidase‐4 (DPP4) inhibitors following hospital discharge in individuals with…
View article: Medication persistence trajectories among individuals prescribed lipid‐lowering therapy in primary care settings: A retrospective cohort study
Medication persistence trajectories among individuals prescribed lipid‐lowering therapy in primary care settings: A retrospective cohort study Open
Aims This study aimed to identify distinct trajectories of lipid‐modifying medication (LMM) persistence over time and to explore characteristics associated with each pattern. Methods Using primary care data from IQVIA, we conducted a retro…
View article: Development of an Australian Clinical Practice Guideline on methylenedioxymethamphetamine (MDMA)-assisted Psychotherapy for Post-traumatic Stress Disorder
Development of an Australian Clinical Practice Guideline on methylenedioxymethamphetamine (MDMA)-assisted Psychotherapy for Post-traumatic Stress Disorder Open
The Guideline will be published on the digital platform MAGICapp and disseminated in peer-reviewed publications, professional conferences and via specific stakeholder groups. A Companion Guide will be developed for people living with PTSD …
View article: Analgesic and adjuvant co‐prescribing in Australian and Finnish residential care homes
Analgesic and adjuvant co‐prescribing in Australian and Finnish residential care homes Open
Objective To explore the co‐prescribing of analgesic and/or adjuvant medications among residents of Australian and Finnish residential care homes. Method Secondary cross‐sectional analyses of prescribing data from residents of 12 Australia…
View article: [RETRACTED] Understanding the Mental Health Impacts of Blue and Green Spaces through Experimental Approaches: A Scoping Review from 2009 to 2024 v1
[RETRACTED] Understanding the Mental Health Impacts of Blue and Green Spaces through Experimental Approaches: A Scoping Review from 2009 to 2024 v1 Open
[RETRACTED] The mental health benefits of blue and green spaces (BGSs) have gained increasing attention for their role in mitigating the adverse effects of urban living on residents, such as stress reduction, mental restoration, and well-b…
View article: Discontinuation of lipid-modifying agents and failure to achieve target LDL cholesterol levels across cardiovascular risk groups
Discontinuation of lipid-modifying agents and failure to achieve target LDL cholesterol levels across cardiovascular risk groups Open
Long-term adherence to LMAs remains a challenge, particularly in low-risk. Target achievement was poor, highlighting gaps in therapeutic optimization, patient engagement, and monitoring.
View article: National audit of the structure and function of Australian residential care medication advisory committees
National audit of the structure and function of Australian residential care medication advisory committees Open
Objective All Australian residential care facilities are recommended to have access to a medication advisory committee (MAC) to provide governance of medication management. The objective was to explore the structure and function of Austral…
View article: Trajectories of new opioid use after hip fracture surgery: a population-based cohort study
Trajectories of new opioid use after hip fracture surgery: a population-based cohort study Open
Introduction: The global annual incidence of hip fractures is projected to double over the next 20 to 30 years. The rates and risk factors for new persistent opioid use after hip fracture surgery remain poorly quantified. Objective: To des…
View article: Dual‐stream algorithms for dementia detection: Harnessing structured and unstructured electronic health record data, a novel approach to prevalence estimation
Dual‐stream algorithms for dementia detection: Harnessing structured and unstructured electronic health record data, a novel approach to prevalence estimation Open
INTRODUCTION Identifying individuals with dementia is crucial for prevalence estimation and service planning, but reliable, scalable methods are lacking. We developed novel set algorithms using both structured and unstructured electronic h…
View article: The impact of real-world evidence in implementing and optimizing Alzheimer’s disease care
The impact of real-world evidence in implementing and optimizing Alzheimer’s disease care Open
Real-world evidence (RWE) can complement clinical trials by addressing gaps in how approved anti-amyloid therapies for early Alzheimer's disease (AD) are used in everyday practice. This article outlines strategies to generate RWE that brid…
View article: Diabetes medication management recommendations for older adults: A systematic review of the Western Pacific region
Diabetes medication management recommendations for older adults: A systematic review of the Western Pacific region Open
Aim The Western Pacific region has the fastest aging population and 38% of the world's diabetes population. It is unknown to what extent medication management recommendations are included for older adults in type 2 diabetes (T2D) clinical …
View article: A digital health-supported Prediabetes Intervention, Management and Evaluation (PRIME) Program improves Healthy Eating Index score: A cluster randomized controlled trial
A digital health-supported Prediabetes Intervention, Management and Evaluation (PRIME) Program improves Healthy Eating Index score: A cluster randomized controlled trial Open
There has been increasing interest in digital health-supported interventions to facilitate lifestyle change for diabetes prevention. In this secondary analysis of a digital health-supported Prediabetes Intervention, Management and Evaluati…
View article: Assessing the impact of an intensive dietitian-led telehealth intervention focusing on nutritional adequacy, symptom control and optional supplemental jejunal feeding, on quality of life in patients with pancreatic cancer: a randomised controlled trial protocol
Assessing the impact of an intensive dietitian-led telehealth intervention focusing on nutritional adequacy, symptom control and optional supplemental jejunal feeding, on quality of life in patients with pancreatic cancer: a randomised controlled trial protocol Open
Background Pancreatic cancer is the third leading cause of cancer-related death in Australia, with a persistently poor 5-year survival rate of around 13%. Symptoms arising from the disease and chemotherapy such as epigastric pain, anorexia…
View article: Comparative risk of major health events among individuals prescribed different antiseizure medications following ischemic stroke
Comparative risk of major health events among individuals prescribed different antiseizure medications following ischemic stroke Open
Objective The aim of this study was to compare the risk of seizure, recurrent stroke, fall or fracture, and mortality in individuals prescribed different antiseizure medications (ASMs) following an ischemic stroke. Methods We identified al…
View article: Evaluating the implementation of a rapid access atrial fibrillation clinic utilising a pharmacist-physician model of care
Evaluating the implementation of a rapid access atrial fibrillation clinic utilising a pharmacist-physician model of care Open
A pharmacist-physician model of care was successfully implemented in a regional health setting, leading to improved access and medication management, with high levels of patient acceptance.
View article: Current and Future Cost Burden of Myocardial Infarction in Australia: Dynamic Multistate Markov Model
Current and Future Cost Burden of Myocardial Infarction in Australia: Dynamic Multistate Markov Model Open
Introduction Myocardial infarction (MI) imposes a significant health burden to the Australian population. However, detailed economic implication of MI on the Australian healthcare system has not been exhaustively explored. Objective To est…
View article: Implementing Australia's new guidelines for appropriate psychotropic medication use in residential aged care: Applying the Consolidated Framework For Implementation Research
Implementing Australia's new guidelines for appropriate psychotropic medication use in residential aged care: Applying the Consolidated Framework For Implementation Research Open
Objectives Accumulating evidence about psychotropic medication‐related adverse events has had minimal apparent impact on overall rates of psychotropic medication use across Australian residential aged care facilities (RACFs). Australia's n…
View article: Development of an Australian Clinical Practice Guideline on methylenedioxymethamphetamine (MDMA)-assisted Psychotherapy for Post-traumatic Stress Disorder
Development of an Australian Clinical Practice Guideline on methylenedioxymethamphetamine (MDMA)-assisted Psychotherapy for Post-traumatic Stress Disorder Open
Introduction Despite recent clinical and research interest, medical use of psychedelics has not been legalised in most jurisdictions. The Australian Therapeutic Goods Administration rescheduled methylenedioxymethamphetamine (MDMA) in July …
View article: Safety and efficacy of methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in post-traumatic stress disorder: An overview of systematic reviews and meta-analyses
Safety and efficacy of methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in post-traumatic stress disorder: An overview of systematic reviews and meta-analyses Open
Objective: To critically evaluate published and unpublished systematic reviews and meta-analyses on the safety and efficacy of methylenedioxymethamphetamine-assisted psychotherapy for post-traumatic stress disorder. Methods: Six bibliometr…
View article: SGLT2 Inhibitors and the Risk of Infections in Type 2 Diabetes: Systematic Review and Meta‐Analyses of Real‐World Evidence
SGLT2 Inhibitors and the Risk of Infections in Type 2 Diabetes: Systematic Review and Meta‐Analyses of Real‐World Evidence Open
Background People with diabetes are at increased risk of infections. Emerging evidence suggests sodium–glucose cotransporter 2 (SGLT2) inhibitors have pleiotropic effects that may protect against certain infections. We systematically revie…