John M. Bennett
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View article: Experiences of Symptom Burden among Young Children Born with Esophageal Atresia-Tracheoesophageal Fistula: a US focus group study
Experiences of Symptom Burden among Young Children Born with Esophageal Atresia-Tracheoesophageal Fistula: a US focus group study Open
Background Children born with esophageal atresia-tracheoesophageal fistula (EA-TEF) can suffer from aerodigestive morbidity that impairs their quality of life and can persist into adulthood. Ameliorating their symptom burden requires a tho…
View article: 193 Endoluminal Vacuum Therapy (EVT) as a Gold Standard for Upper Gastrointestinal Perforations: A 13 Year Experience in a Tertiary Referral Centre
193 Endoluminal Vacuum Therapy (EVT) as a Gold Standard for Upper Gastrointestinal Perforations: A 13 Year Experience in a Tertiary Referral Centre Open
Background There are around 2,800 oesophageal perforations and leaks in the UK each year, with mortality reaching 50% when diagnosis and subsequent treatment is delayed. Management traditionally involved high-risk invasive surgery with pro…
View article: NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 2.2025
NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 2.2025 Open
The NCCN Guidelines for Myelodysplastic Syndromes (MDS) provide recommendations for the evaluation, diagnosis, and comprehensive care of patients with MDS based on a review of recent clinical evidence that has led to important advances in …
View article: EGS SO29 - Therapeutic Endoluminal Vacuum Therapy (EVT) as first line management for oesophageal and selected gastric and duodenal perforations
EGS SO29 - Therapeutic Endoluminal Vacuum Therapy (EVT) as first line management for oesophageal and selected gastric and duodenal perforations Open
Background Upper gastro-intestinal (GI) perforations and leaks affect roughly 2,800 patients annually in the UK. They can occur spontaneously, as a complication of medical intervention, or be due to trauma. Mortality rates are around 20%, …
View article: 443. IMPLEMENTATION OF A PROTOCOL FOR THE DIAGNOSIS AND MANAGEMENT OF LONG-TERM COMPLICATIONS FOLLOWING ESOPHAGECTOMY AND GASTRECTOMY
443. IMPLEMENTATION OF A PROTOCOL FOR THE DIAGNOSIS AND MANAGEMENT OF LONG-TERM COMPLICATIONS FOLLOWING ESOPHAGECTOMY AND GASTRECTOMY Open
Background Surgery remains the mainstay of curative pathway treatment for most patients with esophageal and gastric cancer. Both esophagectomy and gastrectomy carry a significant risk of early post-operative morbidity. The gastrointestinal…
View article: Assessing sociodemographic and regional disparities in Oncotype DX Genomic Prostate Score uptake
Assessing sociodemographic and regional disparities in Oncotype DX Genomic Prostate Score uptake Open
Background The Oncotype DX Genomic Prostate Score (ODX‐GPS) is a gene expression assay that predicts disease aggressiveness. The objective of this study was to identify sociodemographic and regional factors associated with ODX‐GPS uptake. …
View article: Validation of a PHIS Esophageal Atresia and Tracheoesophageal Fistula Cohort in ICD‐10
Validation of a PHIS Esophageal Atresia and Tracheoesophageal Fistula Cohort in ICD‐10 Open
Objective Validation of a contemporary International Classification of Diseases, 10th Revision, Clinical Modification (ICD‐10‐CM) congenital esophageal atresia/tracheoesophageal atresia (EA/TEF) cohort in the Pediatric Health Information S…
View article: EGS P17 Expanding the technical armamentarium to treat complex oesophageal perforations with Endoluminal Vacuum Therapy
EGS P17 Expanding the technical armamentarium to treat complex oesophageal perforations with Endoluminal Vacuum Therapy Open
Background Endoluminal vacuum therapy (EVT) is increasingly the default treatment modality for oesophageal leaks. If the leak cavity is large or has a dependent element, placement of the endoluminal vacuum device within the leak cavity fac…
View article: OGC P03 A protocol for investigation and management of late effects after Upper GI surgery
OGC P03 A protocol for investigation and management of late effects after Upper GI surgery Open
Background Upper GI surgery, and particularly upper GI cancer surgery can result in quality of life limiting symptoms months and years later. While some of these symptoms may be unavoidable, there are a number of conditions which can be tr…
View article: OGC P54 Catastrophic dumping after gastrectomy in a patient with absent pituitary treated with octreotide – case report
OGC P54 Catastrophic dumping after gastrectomy in a patient with absent pituitary treated with octreotide – case report Open
Background Gastrectomy results in a profound change in appetite, satiety and response to food. Most people will adapt and manage to maintain adequate enteral nutrition, however severe symptoms can hamper quality of life. Early dumping, def…
View article: 713 The Role of Enteral Feed Composition on Chyle Leak Prevalence and Severity in Post-Oesophagectomy Patients
713 The Role of Enteral Feed Composition on Chyle Leak Prevalence and Severity in Post-Oesophagectomy Patients Open
Aim Chyle leak presents as an uncommon yet significant complication for post-oesophagectomy patients. This study aims to evaluate the role of enteral feed in the prevalence and severity of chyle leaks post-oesophagectomy. Method We identif…
View article: Acute myelofibrosis superseding B‐lymphoblastic leukemia/lymphoma
Acute myelofibrosis superseding B‐lymphoblastic leukemia/lymphoma Open
The patient is a 68-year-old man diagnosed with B-acute lymphoblastic leukemia/lymphoma (B-ALL) replacing the bone marrow, without evidence of myelofibrosis by morphology and reticulin stain (Figure 1A–C). By flow cytometry analysis, blast…
View article: S170: MYELODYSPLASTIC NEOPLASMS (MDS) CLASSIFICATION FROM WHO 2017 TO WHO 2022 AND ICC 2022): AN EXPANDED ANALYSIS OF 7017 PATIENTS ON BEHALF OF THE INTERNATIONAL CONSORTIUM FOR MDS (ICMDS)
S170: MYELODYSPLASTIC NEOPLASMS (MDS) CLASSIFICATION FROM WHO 2017 TO WHO 2022 AND ICC 2022): AN EXPANDED ANALYSIS OF 7017 PATIENTS ON BEHALF OF THE INTERNATIONAL CONSORTIUM FOR MDS (ICMDS) Open
Topic: 10. Myelodysplastic syndromes - Clinical Background: In 2022 two new classifications for myeloid neoplasms were published: the World Health Organization (WHO) and International Consensus Classification (ICC). Aims: To validate and c…
View article: Left ventricular cellular regression occurs without matrix changes at two months post aortic valve replacement in severe aortic stenosis
Left ventricular cellular regression occurs without matrix changes at two months post aortic valve replacement in severe aortic stenosis Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): British Heart Foundation Background Increased left ventricular mass (LVM) in severe aortic stenosis (AS) is a result of the combined expansion of myocard…
View article: <scp>ICC</scp>‐2022 versus <scp>WHO</scp>‐2022 classification systems for acute leukemias and myeloid neoplasms: The perspective from two classical morphologists
<span>ICC</span>‐2022 versus <span>WHO</span>‐2022 classification systems for acute leukemias and myeloid neoplasms: The perspective from two classical morphologists Open
To the Editor: The recent evolutions of classification approaches in the critical field of the classification of neoplasms of the hematopoietic system1-4 lead us to bring to your attention some considerations, in the hope that they may be …
View article: Obesity in adult acute myeloid leukemia is not associated with inferior response or survival even when dose capping anthracyclines: An ECOG‐ACRIN analysis
Obesity in adult acute myeloid leukemia is not associated with inferior response or survival even when dose capping anthracyclines: An ECOG‐ACRIN analysis Open
Background Obesity (body mass index [BMI] ≥30 kg/m 2 ) is an important epidemiological risk factor for developing acute myeloid leukemia (AML). Therefore, the authors studied the association of obesity with clinical and genetic phenotype a…
View article: Selection of a stress-based soil compaction test to determine potential impact of machine wheel load
Selection of a stress-based soil compaction test to determine potential impact of machine wheel load Open
The use of heavy machinery is increasing in agricultural industries in particular cotton farming systems, which induces an increased risk of soil compaction and yield reduction. Hence, there is a need for a technical solution to use availa…
View article: OGBN P12 Minimising the systemic effects of an oesophageal leak following high risk myotomy repair using Prophylactic Endoluminal Vacuum Therapy (EVT) - time for a change?
OGBN P12 Minimising the systemic effects of an oesophageal leak following high risk myotomy repair using Prophylactic Endoluminal Vacuum Therapy (EVT) - time for a change? Open
Background Endoluminal Vacuum Therapy (EVT) continues to gain momentum as a first line treatment for oesophageal perforations. Outside the emergency setting there is growing interest in using EVT prophylactically to protect high-risk elect…
View article: Mast cell leukemia morphologic illustration of a rare entity
Mast cell leukemia morphologic illustration of a rare entity Open
A 72-year-old woman with no oncologic past medical history presented to the emergency department with several weeks of progressive fatigue, dyspnea, night sweats, intermittent rash, and a 30 lb unintended weight loss. Initial imaging demon…
View article: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arising in the setting of polycythemia vera (PV): An illustration of the emerging role of flow cytometry analysis in monitoring progression of myeloproliferative neoplasms
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arising in the setting of polycythemia vera (PV): An illustration of the emerging role of flow cytometry analysis in monitoring progression of myeloproliferative neoplasms Open
This report highlights the value of flow cytometry analysis, particularly in the setting of myeloproliferative neoplasms showing features of progression, as neoplastic plasmacytoid dendritic cell (PDC) proliferations may be present, repres…
View article: 231 Diagnostic Outcomes in Suspected Appendicitis Before and During the COVID-19 Pandemic
231 Diagnostic Outcomes in Suspected Appendicitis Before and During the COVID-19 Pandemic Open
Introduction Routine operative treatment of appendicitis was temporarily interrupted during the COVID-19 pandemic. Non-operative management in suspected appendicitis makes a definitive diagnosis difficult. This study investigated diagnosti…
View article: NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 3.2022
NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 3.2022 Open
The NCCN Guidelines for Myelodysplastic Syndromes (MDS) provide recommendations for the evaluation, diagnosis, and management of patients with MDS based on a review of clinical evidence that has led to important advances in treatment or ha…
View article: Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update
Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update Open
Myelodysplastic syndrome (MDS) is a diverse hematological malignancy with a wide spectrum of presentations and implications. Treatment strategies for patients with MDS heavily rely on prognostic scoring systems, such as the revised interna…