John Buscombe
YOU?
Author Swipe
View article: The Accomplishments and Legacy of Saul Hertz, MD
The Accomplishments and Legacy of Saul Hertz, MD Open
The early history of the use of radioactive iodine (RAI) is complicated and interesting, and also difficult to discover, especially since several histories have presented inaccurate content. This article is a comprehensive review of the ac…
View article: Commentary on “Radioactive Iodine: A Living History”
Commentary on “Radioactive Iodine: A Living History” Open
TO THE EDITOR: An article was recently published in Thyroid to commemorate the discovery and use of radioiodine for the management of patients with thyroid disease ([1][1]). Although "Radioactive Iodine: A Living History" is overall an exc…
View article: Clinical perspectives on dosimetry in molecular radiotherapy
Clinical perspectives on dosimetry in molecular radiotherapy Open
Molecular radiotherapy is the use of systemically administered unsealed radioactive sources to treat cancer. Theragnostics is the term used to describe paired radiopharmaceuticals localising to a specific target, one optimised for imaging,…
View article: Clinical Utility of 18Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) in Multivisceral Transplant Patients
Clinical Utility of 18Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) in Multivisceral Transplant Patients Open
Multivisceral transplant (MVTx) refers to a composite graft from a cadaveric donor, which often includes the liver, the pancreaticoduodenal complex, and small intestine transplanted en bloc. It remains rare and is performed in specialist c…
View article: Theranostic Radiopharmaceuticals: A Universal Challenging Educational Paradigm in Nuclear Medicine
Theranostic Radiopharmaceuticals: A Universal Challenging Educational Paradigm in Nuclear Medicine Open
The field of nuclear medicine traces its origin to the accidental discovery and naming of radioactivity by Henri Becquerel and Marie Curie in 1896 and 1905. In March 1936, Hamilton and Stone in California used "radiosodium," the first arti…
View article: Association of Complex Lymphatic Drainage in Head and Neck Cutaneous Melanoma With Sentinel Lymph Node Biopsy Outcomes
Association of Complex Lymphatic Drainage in Head and Neck Cutaneous Melanoma With Sentinel Lymph Node Biopsy Outcomes Open
Importance Although sentinel lymph node biopsy (SLNB) is a vital staging tool, its application in head and neck melanoma (HNM) is complicated by a higher false-negative rate (FNR) compared with other regions. This may be due to the complex…
View article: Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying
Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying Open
Objective People who are severely obese due to melanocortin‐4 receptor (MC4R) deficiency experience hyperphagia and impaired fullness after a meal (satiety). Meal‐induced satiety is influenced by hormones, such as peptide‐YY (PYY), which a…
View article: Radiological and Clinical Efficacy of Intra-Arterial 90Y-DOTATATE in Patients with Unresectable, Progressive, Liver Dominant Neuroendocrine Neoplasms
Radiological and Clinical Efficacy of Intra-Arterial 90Y-DOTATATE in Patients with Unresectable, Progressive, Liver Dominant Neuroendocrine Neoplasms Open
This study was performed to determine if intra-arterial (i.a.) administration of 90Y DOTATATE can provide an effective and safe alternative to the accepted standard for i.v. of peptide receptor radionuclide therapy (PRRT) in liver-dominant…
View article: Theragnostics: A Neologism That Generates Schism—The Hellenic Thesis
Theragnostics: A Neologism That Generates Schism—The Hellenic Thesis Open
TO THE EDITOR: Kyrie [sir]: Not as euphonic as theranostics, the term theragnostics, from the Hellenic therapevein [therapy] and “diagnosis,” harmonizes well with “gnosis” and “prognosis” ([ 1 ][1]). The glossologic chasm that can be synth…
View article: Quantifying the survival benefit of completing all the six cycles of radium-223 therapy in patients with castrate-resistant prostate cancer with predominant bone metastases
Quantifying the survival benefit of completing all the six cycles of radium-223 therapy in patients with castrate-resistant prostate cancer with predominant bone metastases Open
A retrospective analysis was performed of epidemiological data assessing the survival of patients who had received radium-223 for castrate-resistant metastatic prostate cancer treated at a regional tertiary referral center over a 5-year pe…
View article: Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT
Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT Open
Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with…
View article: COVID-19: guidance for infection prevention and control in nuclear medicine
COVID-19: guidance for infection prevention and control in nuclear medicine Open
This guidance document is a brief consensus document covering the range and breadth of nuclear medicine practice in the UK, and identifies a few steps individual nuclear medicine practitioners and departments can take in the best interests…
View article: The World Association of Radiopharmaceutical and Molecular Therapy position statement on the initial radioiodine therapy for differentiated thyroid carcinoma
The World Association of Radiopharmaceutical and Molecular Therapy position statement on the initial radioiodine therapy for differentiated thyroid carcinoma Open
The World Association of Radiopharmaceutical and Molecular
\nTherapy (WARMTH) is a worldwide nonprofit organization,
\nwhich is dedicated to educating medical professionals in
\nthe use of radionuclide therapies based on the theragnostic
\…
View article: Response to Huisstede et al. Increased eosinophil uptake in the lungs of obese asthmatics – to correct for obesity compare to obese controls
Response to Huisstede et al. Increased eosinophil uptake in the lungs of obese asthmatics – to correct for obesity compare to obese controls Open
To The Editor: We thank Huisstede and colleagues for their interest in our publication and their comments.1 Like the authors we agree wholeheartedly that weight reduction is key to improving asthma control and quality of life in obese pati…
View article: Use of 18F FDG PET and the short temporal response of Hodgkin's disease to RIT
Use of 18F FDG PET and the short temporal response of Hodgkin's disease to RIT Open
Radioimmunotherapy (RIT) has been available for some time to treat patients with non-Hodgkin's lymphoma, but its use in Hodgkin's lymphoma has been less available, partly because of the need to find an appropriate antibody. A new radioiodi…
View article: Red flag or red herring
Red flag or red herring Open
© 2018. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the o…
View article: First results and experience with PRRT in South Africa
First results and experience with PRRT in South Africa Open
Neuroendocrine tumors (NETs) are a diverse group of tumors that often present late due to nonspecific symptoms. These tumors frequently express somatostatin receptors (SSRs), which allows for positron emission tomography/computed tomograph…
View article: The use of 67Ga scintigraphy in patients with sarcoidosis
The use of 67Ga scintigraphy in patients with sarcoidosis Open
Sarcoidosis is a systemic disease of unknown aetiology characterised by the formation of noncaseating granulomas in various organs and tissues. The various imaging modalities that are useful in the investigation of lesions, staging and est…
View article: S65 Quantification of ‘whole lung’ pulmonary eosinophilic inflammation using radiolabelled autologous human eosinophils
S65 Quantification of ‘whole lung’ pulmonary eosinophilic inflammation using radiolabelled autologous human eosinophils Open
Background Eosinophils are key mediators of allergic inflammation. The ability to localise and quantify eosinophilic inflammation in vivo would facilitate patient endotyping and evaluation of eosinophil-targeted therapeutics. We aimed to q…
View article: Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management
Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management Open
Objective In adults with hyperinsulinaemic hypoglycaemia (HH), in particular those with insulinoma, the optimal diagnostic and management strategies remain uncertain. Here, we sought to characterise the biochemical and radiological assessm…
View article: D Atherosclerotic inflammation imaging using <sup>68</sup>ga-dotatate pet vs. <sup>18</sup>f-fdg pet: a prospective clinical sudy with molecular and histological validation
D Atherosclerotic inflammation imaging using <sup>68</sup>ga-dotatate pet vs. <sup>18</sup>f-fdg pet: a prospective clinical sudy with molecular and histological validation Open
Background Inflammation drives atherosclerotic plaque rupture underlying most clinical events. While inflammation can be measured using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET), 18F-FDG lacks cell-specificity and is …