John C. Adair
YOU?
Author Swipe
View article: Blood-brain barrier disruption measured by albumin index correlates with inflammatory fluid biomarkers
Blood-brain barrier disruption measured by albumin index correlates with inflammatory fluid biomarkers Open
Introduction: The blood-brain barrier (BBB) is important in vascular cognitive impairment dementia (VCID) and Alzheimer's disease (AD). There are two methods uto measures BBB permeability: 1) the ratio of the concentration of albumin in bl…
View article: A Trichotomy Method for Defining Homogeneous Subgroups in a Dementia Population Improves Patient Classification
A Trichotomy Method for Defining Homogeneous Subgroups in a Dementia Population Improves Patient Classification Open
Introduction: Clinical diagnosis of dementia is difficult due to the presence of multiple etiologies with mixed dementia (MX) the most common. MX has been found at autopsy but has been difficult to diagnose during life. Earlier we reported…
View article: A trichotomy method for defining homogeneous subgroups in a dementia population
A trichotomy method for defining homogeneous subgroups in a dementia population Open
Introduction Diagnosis of dementia in the aging brain is confounded by the presence of multiple pathologies. Mixed dementia (MX), a combination of Alzheimer's disease (AD) proteins with vascular disease (VD), is frequently found at autopsy…
View article: Blood-brain barrier disruption measured by albumin index correlates with inflammatory fluid biomarkers
Blood-brain barrier disruption measured by albumin index correlates with inflammatory fluid biomarkers Open
Blood-brain barrier (BBB) permeability can be measured by the ratio of albumin in cerebrospinal fluid (CSF) and blood and by dynamic contrast-enhanced MRI (DCEMRI). Albumin is a large molecule measured in CSF and blood to form the albumin …
View article: Inflammatory Biomarkers Aid in Diagnosis of Dementia
Inflammatory Biomarkers Aid in Diagnosis of Dementia Open
Dual pathology of Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) commonly are found together at autopsy, but mixed dementia (MX) is difficult to diagnose during life. Biological criteria to diagnose AD have …
View article: A Multimodal Approach to Stratification of Patients with Dementia: Selection of Mixed Dementia Patients Prior to Autopsy
A Multimodal Approach to Stratification of Patients with Dementia: Selection of Mixed Dementia Patients Prior to Autopsy Open
Alzheimer’s disease (AD) and vascular cognitive impairment and dementia (VCID) are major causes of dementia, and when combined lead to accelerated cognitive loss. We hypothesized that biomarkers of neurodegeneration and neuroinflammation c…
View article: Altered static and dynamic functional network connectivity in Alzheimer's disease and subcortical ischemic vascular disease: shared and specific brain connectivity abnormalities
Altered static and dynamic functional network connectivity in Alzheimer's disease and subcortical ischemic vascular disease: shared and specific brain connectivity abnormalities Open
Subcortical ischemic vascular disease (SIVD) is a major subtype of vascular dementia with features that overlap clinically with Alzheimer's disease (AD), confounding diagnosis. Neuroimaging is a more specific and biologically based approac…
View article: MEG biomarker of Alzheimer's disease: Absence of a prefrontal generator during auditory sensory gating
MEG biomarker of Alzheimer's disease: Absence of a prefrontal generator during auditory sensory gating Open
Magnetoencephalography (MEG), a direct measure of neuronal activity, is an underexplored tool in the search for biomarkers of Alzheimer's disease (AD). In this study, we used MEG source estimates of auditory gating generators, nonlinear co…
View article: Brain structure and verbal function across adulthood while controlling for cerebrovascular risks
Brain structure and verbal function across adulthood while controlling for cerebrovascular risks Open
The development and decline of brain structure and function throughout adulthood is a complex issue, with cognitive aging trajectories influenced by a host of factors including cerebrovascular risk. Neuroimaging studies of age‐related cogn…