Explanipedia

Discovery and validation of genes driving drug‐intake and related behavioral traits in mice Open

Tyler Roy, Jason A. Bubier, Price E. Dickson, Troy Wilcox, Juliet Ndukum , et al. · 2024

Substance use disorders are heritable disorders characterized by compulsive drug use, the biological mechanisms for which remain largely unknown. Genetic correlations reveal that predisposing drug‐naïve phenotypes, including anxiety, depre…

DISCOVERY AND VALIDATION OF GENES DRIVING DRUG-INTAKE AND RELATED BEHAVIORAL TRAITS IN MICE Open

Tyler Roy, Jason A. Bubier, Price E. Dickson, Troy Wilcox, Juliet Ndukum , et al. · 2023

Substance use disorders (SUDs) are heritable disorders characterized by compulsive drug use, but the biological mechanisms driving addiction remain largely unknown. Genetic correlations reveal that predisposing drug-naïve phenotypes, inclu…

Preclinical and clinical evidence for suppression of alcohol intake by apremilast Open

Kolter B. Grigsby, Regina A. Mangieri, Amanda J. Roberts, Marcelo F. Lopez, Evan J. Firsick , et al. · 2023

Treatment options for alcohol use disorders (AUDs) have minimally advanced since 2004, while the annual deaths and economic toll have increased alarmingly. Phosphodiesterase type 4 (PDE4) is associated with alcohol and nicotine dependence.…

Midazolam, methamphetamine, morphine and nicotine intake in high‐drinking‐in‐the‐dark mice Open

Antonia M. Savarese, Pamela Metten, Tamara J. Phillips, Bryan E. Jensen, John C. Crabbe , et al. · 2022

The high‐drinking‐in‐the‐dark (HDID) lines of mice were selectively bred for achieving high blood alcohol levels in the drinking‐in‐the‐dark (DID) task and have served as a unique genetic risk model for binge‐like alcohol intake. However, …

Corticosterone Levels and Glucocorticoid Receptor Gene Expression in High Drinking in the Dark Mice and Their Heterogeneous Stock (HS/NPT) Founder Line Open

Antonia M. Savarese, Kolter B. Grigsby, Bryan E. Jensen, Marissa B. Borrego, Deborah A. Finn , et al. · 2022

The High Drinking in the Dark (HDID-1) line of mice has been selectively bred for achieving high blood alcohol levels (BALs) in the Drinking in the Dark task, a model of binge-like drinking. Recently, we determined that glucocorticoid rece…

Long‐term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects Open

John C. Crabbe, Wyatt Hack, Angela R. Ozburn, Antonia M. Savarese, Pamela Metten · 2021

We have modelled genetic risk for binge‐like drinking by selectively breeding High Drinking in the Dark‐1 and ‐2 (HDID‐1 and HDID‐2) mice for their propensity to reach intoxicating blood alcohol levels (BALs) after binge‐like drinking in a…

The FDA-approved drug apremilast suppresses alcohol intake: clinical and pre-clinical validation Open

Kolter B. Grigsby, Regina A. Mangieri, Amanda J. Roberts, Marcelo J Lopez, Alexander Tran , et al. · 2021

Treatment options for Alcohol Use Disorders (AUD) have minimally advanced since 2004, while the annual deaths and economic toll have become alarmingly high. Bringing potential therapeutics beyond the bench and into the clinic for AUD requi…

The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice Open

Antonia M. Savarese, Angela R. Ozburn, Amanda M. Barkley‐Levenson, Pamela Metten, John C. Crabbe · 2021

Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication Open

Bryan E. Jensen, Kayla G. Townsley, Kolter B. Grigsby, Pamela Metten, M.Bhavana Annie Chand M.Bhavana Annie Chand , et al. · 2021

Alcohol use disorder (AUD) is a devastating psychiatric disorder that has significant wide-reaching effects on individuals and society. Selectively bred mouse lines are an effective means of exploring the genetic and neuronal mechanisms un…

Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice Open

John C. Crabbe, Angela R. Ozburn, Robert Hitzemann, Stephanie E. Spence, Wyatt Hack , et al. · 2020

Targeting the Glucocorticoid Receptor Reduces Binge‐Like Drinking in High Drinking in the Dark (HDID‐1) Mice Open

Antonia M. Savarese, Angela R. Ozburn, Pamela Metten, Jason P. Schlumbohm, Wyatt Hack , et al. · 2020

Background Chronic alcohol exposure can alter glucocorticoid receptor (GR) function in some brain areas that promotes escalated and compulsive‐like alcohol intake. GR antagonism can prevent dependence‐induced escalation in drinking, but ve…

Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice Open

Kolter B. Grigsby, Antonia M. Savarese, Pamela Metten, Barbara J. Mason, Yuri A. Blednov , et al. · 2020

High Drinking in the Dark (HDID-1) mice represent a unique genetic risk model of binge-like drinking and a novel means of screening potential pharmacotherapies to treat alcohol use disorders (AUDs). We tested the effects of tacrolimus (0, …

Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication Open

Angela R. Ozburn, Pamela Metten, Sheena Potretzke, Kayla G. Townsley, Yuri A. Blednov , et al. · 2019

Background Rodent models of high alcohol drinking offer opportunities to better understand factors for alcohol use disorders (AUD) and test potential treatments. Selective breeding was carried out to create 2 unique High Drinking in the Da…

Suppression of voluntary ethanol intake in mice under constant light and constant darkness Open

Alan M. Rosenwasser, Walter D. McCulley, Matthew C. Hartmann, Michael C. Fixaris, John C. Crabbe · 2019

Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long‐Term Alcohol Abstinence Open

Matthew C. Hartmann, Sarah E. Holbrook, Megan M. Haney, John C. Crabbe, Alan M. Rosenwasser · 2019

Background While the acute alcohol withdrawal syndrome has been well characterized both in human clinical studies and in experimental animals, much less is known regarding long‐term affective disturbances that can sometimes persist during …

Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice Open

John C. Crabbe, Pamela Metten, Antonia M. Savarese, Angela R. Ozburn, Jason P. Schlumbohm , et al. · 2019

Two independent lines of High Drinking in the Dark (HDID-1, HDID-2) mice have been bred to reach high blood alcohol levels after a short period of binge-like ethanol drinking. Male mice of both lines were shown to have reduced sensitivity …

Stable Histone Methylation Changes at Proteoglycan Network Genes Following Ethanol Exposure Open

David P. Gavin, Joel G. Hashimoto, Nathan H. Lazar, Lucia Carbone, John C. Crabbe , et al. · 2018

Alcohol use disorder (AUD) is a chronic mental illness in which patients often achieve protracted periods of abstinence prior to relapse. Epigenetic mechanisms may provide an explanation for the persisting gene expression changes that can …

Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach Open

Laura B. Ferguson, Lingling Zhang, Daniel M. Kircher, Shi Wang, R. Dayne Mayfield , et al. · 2018

Alcohol use disorder (AUD) is a complex psychiatric disorder with strong genetic and environmental risk factors. We studied the molecular perturbations underlying risky drinking behavior by measuring transcriptome changes across the neuroc…

Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge‐Like Alcohol Drinking in Mice Open

Kush Purohit, Puja K. Parekh, Joseph R. Kern, Ryan W. Logan, Zheng Liu , et al. · 2018

Background Chronic alcohol intake leads to long‐lasting changes in reward‐ and stress‐related neuronal circuitry. The nucleus accumbens ( NA c) is an integral component of this circuitry. Here, we investigate the effects of DREADD s (Desig…

Reproducibility and replicability of rodent phenotyping in preclinical studies Open

Neri Kafkafi, Joseph Agassi, Elissa J. Chesler, John C. Crabbe, Wim E. Crusio , et al. · 2018

The scientific community is increasingly concerned with the proportion of published "discoveries" that are not replicated in subsequent studies. The field of rodent behavioral phenotyping was one of the first to raise this concern, and to …

Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice Open

Laura B. Ferguson, Angela R. Ozburn, Igor Ponomarev, Pamela Metten, Matthew T. Reilly , et al. · 2017

High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking Open

John C. Crabbe, Angela R. Ozburn, Pamela Metten, Amanda M. Barkley‐Levenson, Jason P. Schlumbohm , et al. · 2017

Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID) Open

Robert Hitzemann, Denesa Oberbeck, Ovidiu D. Iancu, Priscila Darakjian, Shannon K. McWeeney , et al. · 2017

Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence Open

Joel G. Hashimoto, David P. Gavin, Kristine M. Wiren, John C. Crabbe, Marina Guizzetti · 2017

Reproducibility and replicability of rodent phenotyping in preclinical studies Open

Neri Kafkafi, Joseph Agassi, Elissa J. Chesler, John C. Crabbe, Wim E. Crusio , et al. · 2016

The scientific community is increasingly concerned with cases of published “discoveries” that are not replicated in further studies. The field of mouse behavioral phenotyping was one of the first to raise this concern, and to relate it to …

Progress With Nonhuman Animal Models of Addiction Open

John C. Crabbe · 2016

Nonhuman animals have been major contributors to the science of the genetics of addiction. Given the explosion of interest in genetics, it is fair to ask, are we making reasonable progress toward our goals with animal models? I will argue …

Effects of acute alcohol withdrawal on nest building in mice selectively bred for alcohol withdrawal severity Open

Gian D. Greenberg, Tamara J. Phillips, John C. Crabbe · 2016

Distinct ethanol drinking microstructures in two replicate lines of mice selected for drinking to intoxication Open

Amanda M. Barkley‐Levenson, John C. Crabbe · 2016

Genes, Brain and Behavior 14(5): 398–410 DOI: 10.1111/gbb.12225 The authors have detected an error in the reporting of the statistical analysis of ethanol preference ratio. The text currently states, “Analysis of ethanol preference ratio (…

Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking Open

John C. Crabbe, Jason P. Schlumbohm, Wyatt Hack, Amanda M. Barkley‐Levenson, Pamela Metten , et al. · 2016

Nest building is a novel method for indexing severity of alcohol withdrawal in mice Open

Gian D. Greenberg, Lawrence C. Huang, Stephanie E. Spence, Jason P. Schlumbohm, Pamela Metten , et al. · 2016

John C. Crabbe YOU? Author Swipe