John C. Hancock
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View article: 923 Development of novel agonists for human iNKT cells
923 Development of novel agonists for human iNKT cells Open
View article: IMMU-82. Neuronal modulation of immunity in glioblastoma
IMMU-82. Neuronal modulation of immunity in glioblastoma Open
Recent studies determined that in glioblastoma, tumor cells integrate into neural networks, forming synapses with neurons, enhancing neuronal firing facilitating tumor growth. We sought to understand how neuronal activity alters the functi…
View article: 802 Neuronal modulation of immunity in glioblastoma
802 Neuronal modulation of immunity in glioblastoma Open
View article: 1200 Tumor-specific resident memory-like T cells induced by viral vector vaccination mediate protection against orthotopic murine glioblastoma
1200 Tumor-specific resident memory-like T cells induced by viral vector vaccination mediate protection against orthotopic murine glioblastoma Open
View article: TGF-β and BMP signaling are associated with the transformation of glioblastoma to gliosarcoma and then osteosarcoma
TGF-β and BMP signaling are associated with the transformation of glioblastoma to gliosarcoma and then osteosarcoma Open
Background Gliosarcoma, an isocitrate dehydrogenase wildtype (IDH-WT) variant of glioblastoma, is defined by clonal biphasic differentiation into gliomatous and sarcomatous components. While the transformation from a glioblastoma to gliosa…
View article: 1477 Neuronal modulation of myeloid cells in glioblastoma
1477 Neuronal modulation of myeloid cells in glioblastoma Open
Background Cancer neuroscience is emerging as an important field in glioblastoma (GBM) research. Immuno-oncology has never had a successful phase III clinical trial treating GBM patients and we hypothesize that neuronal drivers of immune c…
View article: Exploring the origin of the cancer stem cell niche and its role in anti-angiogenic treatment for glioblastoma
Exploring the origin of the cancer stem cell niche and its role in anti-angiogenic treatment for glioblastoma Open
Cancer stem cells are thought to be the main drivers of tumorigenesis for malignancies such as glioblastoma (GBM). They are maintained through a close relationship with the tumor vasculature. Previous literature has well-characterized the …
View article: CD5 Deficiency Alters Helper T Cell Metabolic Function and Shifts the Systemic Metabolome
CD5 Deficiency Alters Helper T Cell Metabolic Function and Shifts the Systemic Metabolome Open
Metabolic function plays a key role in immune cell activation, destruction of foreign pathogens, and memory cell generation. As T cells are activated, their metabolic profile is significantly changed due to signaling cascades mediated by t…
View article: Making a Cold Tumor Hot: The Role of Vaccines in the Treatment of Glioblastoma
Making a Cold Tumor Hot: The Role of Vaccines in the Treatment of Glioblastoma Open
The use of immunotherapies for the treatment of brain tumors is a topic that has garnered considerable excitement in recent years. Discoveries such as the presence of a glymphatic system and immune surveillance in the central nervous syste…
View article: CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs
CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs Open
CD4 + T cells are crucial for effective repression and elimination of cancer cells. Despite a paucity of CD4 + T cell receptor (TCR) clinical studies, CD4 + T cells are primed to become important therapeutics as they help circumvent tumor …
View article: <scp>MTA</scp>1‐activated Epi‐micro<scp>RNA</scp>‐22 regulates E‐cadherin and prostate cancer invasiveness
<span>MTA</span>1‐activated Epi‐micro<span>RNA</span>‐22 regulates E‐cadherin and prostate cancer invasiveness Open
We have previously shown that metastasis‐associated protein 1 ( MTA 1), a chromatin remodeler, plays an important role in prostate cancer invasiveness, likely through regulation of epithelial‐to‐mesenchymal transition. Here, we identified …
View article: Ductal Carcinoma In situ of the Male Breast
Ductal Carcinoma In situ of the Male Breast Open
Background: Ductal carcinoma in situ of the male breast is an unusual lesion and most often associated with invasive carcinoma. On rare occasions when the in situ component is present in pure form, histological grade is almos…