John C. Macbeth
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View article: The Novavax Heterologous Coronavirus Disease 2019 Booster Demonstrates Lower Reactogenicity Than Messenger RNA: A Targeted Review
The Novavax Heterologous Coronavirus Disease 2019 Booster Demonstrates Lower Reactogenicity Than Messenger RNA: A Targeted Review Open
Coronavirus disease 2019 (COVID-19) continues to be a global health concern, and booster doses are necessary for maintaining vaccine-mediated protection, limiting the spread of severe acute respiratory syndrome coronavirus 2. Despite multi…
View article: Microbiome induced complement synthesized in the gut protects against enteric infections
Microbiome induced complement synthesized in the gut protects against enteric infections Open
Canonically, complement is a serum-based host defense system that protects against systemic microbial invasion. Little is known about the production and function of complement components on mucosal surfaces. Here we show gut complement com…
View article: Oral antibiotics reduce voluntary exercise behavior in athletic mice
Oral antibiotics reduce voluntary exercise behavior in athletic mice Open
The gut microbiome can affect various aspects of both behavior and physiology, including exercise ability, but effects on voluntary exercise have rarely been studied. We studied females from a selection experiment in which 4 replicate High…
View article: Induction of distinct neuroinflammatory markers and gut dysbiosis by differential pyridostigmine bromide dosing in a chronic mouse model of GWI showing persistent exercise fatigue and cognitive impairment
Induction of distinct neuroinflammatory markers and gut dysbiosis by differential pyridostigmine bromide dosing in a chronic mouse model of GWI showing persistent exercise fatigue and cognitive impairment Open
Our findings demonstrate that GW agents dose-dependently induce differential neuropathology and gut dysbiosis associated with cognitive, exercise fatigue and mood GWI phenotypes. Establishment of a comprehensive animal model that recapitul…
View article: The Interface of <i>Vibrio cholerae</i> and the Gut Microbiome
The Interface of <i>Vibrio cholerae</i> and the Gut Microbiome Open
The bacterium Vibrio cholerae is the etiologic agent of the severe human diarrheal disease cholera. The gut microbiome, or the native community of microorganisms found in the human gastrointestinal tract, is increasingly being recognized a…
View article: The autoimmune susceptibility gene, <i>PTPN2</i> , restricts expansion of a novel mouse adherent-invasive <i>E. coli</i>
The autoimmune susceptibility gene, <i>PTPN2</i> , restricts expansion of a novel mouse adherent-invasive <i>E. coli</i> Open
Inflammatory bowel disease (IBD) pathogenesis involves significant contributions from genetic and environmental factors. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 (PTPN2…
View article: A Dysbiotic Gut Microbiome Suppresses Antibody Mediated-Protection Against<i>Vibrio cholerae</i>
A Dysbiotic Gut Microbiome Suppresses Antibody Mediated-Protection Against<i>Vibrio cholerae</i> Open
Vibrio cholerae is the etiologic agent of cholera, a severe diarrheal disease that represents a significant burden on global health and productivity. Despite the pressing need, available preventative measures such as oral cholera vaccines …
View article: The Autoimmune Susceptibility Gene, <i>PTPN2</i>, Restricts Expansion of a Novel Mouse Adherent-Invasive <i>E. coli</i>
The Autoimmune Susceptibility Gene, <i>PTPN2</i>, Restricts Expansion of a Novel Mouse Adherent-Invasive <i>E. coli</i> Open
Inflammatory bowel diseases (IBD) involve genetic and environmental factors that play major roles in disease pathogenesis. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 ( PT…