John C. Morgan
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View article: Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control Open
Alzheimer's disease (AD) has traditionally been associated with amyloid-β plaques, but growing evidence underscores the role of neuroinflammation in disease progression. The autoinflammatory hypothesis of AD suggests chronic immune dysfunc…
View article: Automated Imaging Differentiation for Parkinsonism
Automated Imaging Differentiation for Parkinsonism Open
Importance Magnetic resonance imaging (MRI) paired with appropriate disease-specific machine learning holds promise for the clinical differentiation of Parkinson disease (PD), multiple system atrophy (MSA) parkinsonian variant, and progres…
View article: Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control Open
Alzheimer’s disease has traditionally been associated with amyloid-β plaques, but growing evidence underscores the role of neuroinflammation in disease progression. The autoimmune hypothesis of Alzheimer’s disease suggests chronic inflamma…
View article: Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease
Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a challenging medical issue that requires efficacious treatment options to improve long-term quality of life. Cannabidiol (CBD) is a cannabis-derived phytocannabinoid with potential health benefits, including re…
View article: Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson’s disease study
Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson’s disease study Open
Estimates of the spectrum and frequency of pathogenic variants in Parkinson’s disease (PD) in different populations are currently limited and biased. Furthermore, although therapeutic modification of several genetic targets has reached the…
View article: Understanding neuropsychiatric symptoms in Alzheimer’s disease: challenges and advances in diagnosis and treatment
Understanding neuropsychiatric symptoms in Alzheimer’s disease: challenges and advances in diagnosis and treatment Open
Neuropsychiatric symptoms (NPS) in Alzheimer’s disease (AD) affect up to 97% of AD patients, with an estimated 80% of current AD patients experiencing these symptoms. Common AD-associated NPS include depression, anxiety, agitation, aggress…
View article: The Georgia Memory Net: Implementation of a statewide program to diagnose and treat Alzheimer's disease and related dementias
The Georgia Memory Net: Implementation of a statewide program to diagnose and treat Alzheimer's disease and related dementias Open
Objectives The number of people living with dementia is growing and most patients go years without receiving a specific diagnosis or support services, leading to suboptimal care, negative impacts on the quality of life, and increased costs…
View article: Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment
Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment Open
Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) and its interaction with tumor cells play important roles in the d…
View article: Low-Dose Niacin Supplementation Improves Motor Function in US Veterans with Parkinson’s Disease: A Single-Center, Randomized, Placebo-Controlled Trial
Low-Dose Niacin Supplementation Improves Motor Function in US Veterans with Parkinson’s Disease: A Single-Center, Randomized, Placebo-Controlled Trial Open
A six-month double-blind, placebo-controlled randomized study was conducted to ascertain whether low-dose daily niacin supplementation would improve motor symptoms in Parkinson’s disease (PD) patients. A total of 47 PD patients were assign…
View article: T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications
T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications Open
Development of complications in type 1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort of 1646 patients diagnosed with type 1 diabetes (T1D) to develop a clinical risk score for diabetic periphe…
View article: A potential role for cannabichromene in modulating TRP channels during acute respiratory distress syndrome
A potential role for cannabichromene in modulating TRP channels during acute respiratory distress syndrome Open
Background Acute respiratory distress syndrome (ARDS) is a life-threatening clinical syndrome whose potential to become one of the most grievous challenges of the healthcare system evidenced by the COVID-19 pandemic. Considering the lack o…
View article: Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression
Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression Open
ClinicalTrials.gov Identifier: NCT02642393.
View article: T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications
T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications Open
Development of complications in type-1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort of 1646 patients diagnosed with type 1 diabetes (T1D) to develop a clinical risk score for diabetic periphe…
View article: Low dose niacin versus placebo in the treatment of Parkinson’s Disease: A Randomized Controlled Trial
Low dose niacin versus placebo in the treatment of Parkinson’s Disease: A Randomized Controlled Trial Open
BackgroundParkinson’s Disease (PD) patients have lower niacin levels compared to their spouses. The main objective was to study low-dose daily niacin supplementation versus placebo on motor symptoms in Parkinson’s disease subjects.MethodsA…
View article: Low Dose Niacin Versus Placebo Treatment for Parkinson's Disease: A Randomized Controlled Trial
Low Dose Niacin Versus Placebo Treatment for Parkinson's Disease: A Randomized Controlled Trial Open
Background Parkinson's Disease (PD) patients have lower niacin levels compared to their spouses. The main objective was to study low-dose daily niacin supplementation on motor symptoms in Parkinson's disease subjects. Methods Forty-Seven P…
View article: Niacin Enhancement for Parkinson’s Disease: An Effectiveness Trial
Niacin Enhancement for Parkinson’s Disease: An Effectiveness Trial Open
We previously reported that individuals with Parkinson’s disease (PD) present with lower vitamin B3 levels compared to controls. It may be related to carbidopa interaction, defective tryptophan metabolism, and stresses of night sleep disor…
View article: Serum Levels of Inflammatory Proteins Are Associated With Peripheral Neuropathy in a Cross-Sectional Type-1 Diabetes Cohort
Serum Levels of Inflammatory Proteins Are Associated With Peripheral Neuropathy in a Cross-Sectional Type-1 Diabetes Cohort Open
Chronic low-grade inflammation is involved in the pathogenesis of type-1 diabetes (T1D) and its complications. In this cross-section study design, we investigated association between serum levels of soluble cytokine receptors with presence…
View article: Pimavanserin Treatment for Parkinson’s Disease Psychosis in Clinical Practice
Pimavanserin Treatment for Parkinson’s Disease Psychosis in Clinical Practice Open
Background. Parkinson’s disease psychosis (PDP) is a common, nonmotor symptom of Parkinson’s disease (PD), which may affect up to 60% of patients and is associated with impaired quality of life, increased healthcare costs, and nursing home…
View article: Prospective Home-use Study on Non-invasive Neuromodulation Therapy for Essential Tremor
Prospective Home-use Study on Non-invasive Neuromodulation Therapy for Essential Tremor Open
This study suggests that non-invasive neuromodulation therapy used repeatedly at home over three months results in safe and effective hand tremor reduction in many essential tremor patients.
View article: Niacin for Parkinson's disease
Niacin for Parkinson's disease Open
Parkinson's disease (PD) is a neurodegenerative disease associated with progressive loss of motor function and cognitive decline occurring in 1% of the USA population. There is no cure for PD, and current treatment regimens are directed to…
View article: Tremor and Dystonia in Jacob's Syndrome (47,XYY)
Tremor and Dystonia in Jacob's Syndrome (47,XYY) Open
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View article: Exploring the cognitive workload during a visual search task in Parkinson's Disease
Exploring the cognitive workload during a visual search task in Parkinson's Disease Open
International Congress of Parkinson's Disease and Movement Disorders , NICE, FRANCE, 22-/09/2019 - 26/09/2019
View article: Niacin Ameliorates Neuro-Inflammation in Parkinson’s Disease via GPR109A
Niacin Ameliorates Neuro-Inflammation in Parkinson’s Disease via GPR109A Open
In this study, we used macrophage RAW264.7 cells to elucidate the molecular mechanism underlying the anti-inflammatory actions of niacin. Anti-inflammatory actions of niacin and a possible role of its receptor GPR109A have been studied pre…
View article: Neuropsychiatric Symptoms in Dementia: Considerations for Pharmacotherapy in the USA
Neuropsychiatric Symptoms in Dementia: Considerations for Pharmacotherapy in the USA Open
Dementia affects all domains of cognition. The relentless progression of the disease after diagnosis is associated with a 98% incidence of neuropsychiatric symptoms (NPS) at some point in the disease, including depression, psychosis, agita…