Explanipedia

D-PLACE dataset derived from Olson et al. 2001 'Terrestrial Ecoregions of the World' Open

David M. Olson, Eric Dinerstein, Eric Wikramanayake, Neil Burgess, George V. N. Powell , et al. · 2025

Cite the source of the dataset as: Olson, D. M., Dinerstein, E., Wikramanayake, E. D., Burgess, N. D., Powell, G. V. N., Underwood, E. C., D'Amico, J. A., Itoua, I., Strand, H. E., Morrison, J. C., Loucks, C. J., Allnutt, T. F., Ricketts, …

A system for producing controlled elevation of intraocular pressure in awake Brown Norway rats Open

John C. Morrison, William O. Cepurna, Eliesa Ing, Elaine C. Johnson, Aryana Abtin , et al. · 2025

Animal models that help us understand how elevated intraocular pressure (IOP) causes axonal injury will lead to new glaucoma therapies. Because reliable measurements are difficult to obtain in chronic models, we developed the controlled el…

Classification of direct threats to the conservation of ecosystems and species 4.0 Open

Nick Salafsky, Claire Relton, Bruce E. Young, P. A. Greg Lamarre, Monika Böhm , et al. · 2024

Identifying and assessing the magnitude of direct threats to ecosystems and species are critical steps to prioritizing, planning, implementing, and assessing conservation actions. Just as medical clinicians and researchers need a standard …

Profiling IOP-Responsive Genes in the Trabecular Meshwork and Optic Nerve Head in a Rat Model of Controlled Elevation of Intraocular Pressure Open

Diana C. Lozano, Yong-Feng Yang, William O. Cepurna, Barbara F. Smoody, Eliesa Ing , et al. · 2024

This study demonstrated the ability to assay short-term IOP-responsive genes in both TM and ONH tissues simultaneously. In the TM, downregulation of TGFβ pathway genes suggests that TM responses may reduce TGFβ-induced extracellular matrix…

Whole-ocean network design and implementation pathway for Arctic marine conservation Open

T. D. James, Martin Sommerkorn, B. A. Solov’yev, Н. Г. Платонов, John C. Morrison , et al. · 2024

Source Invariance and Probabilistic Transfer: A Testable Theory of Probabilistic Neural Representations Open

Samuel Lippl, Raphael T. Gerraty, John C. Morrison, Nikolaus Kriegeskorte · 2024

As animals interact with their environments, they must infer properties of their surroundings. Some animals, including humans, can represent uncertainty about those properties. But when, if ever, do they use probability distributions to re…

Profiling IOP-responsive genes in anterior and posterior ocular tissues in the rat CEI glaucoma model Open

Diana C. Lozano, Yongfeng Yang, William O. Cepurna, Barbara F. Smoody, Eliesa Ing , et al. · 2024

Purpose The rat Controlled Elevation of Intraocular pressure (CEI) model allows study of in vivo responses to defined intraocular pressures (IOP). In this study, we use Nanostring technology to investigate in vivo IOP-related gene response…

A System for Producing Controlled Elevation of Intraocular Pressure in Awake Brown Norway Rats Open

John C. Morrison, William O. Cepurna, Eliesa Ing, Elaine C. Johnson, Aryana Abtin , et al. · 2024

Controlled Elevation of Intraocular Pressure in Anesthetized Mice Open

Diana C. Lozano, William O. Cepurna, Elaine C. Johnson, John C. Morrison · 2024

D-PLACE dataset derived from Olson et al. 2001 'Terrestrial Ecoregions of the World' Open

David M. Olson, Eric Dinerstein, Eric Wikramanayake, Neil Burgess, George V. N. Powell , et al. · 2023

<p>Cite the source of the dataset as:</p>\n\n<blockquote>\n<p>Olson, D. M., Dinerstein, E., Wikramanayake, E. D., Burgess, N. D., Powell, G. V. N., Underwood, E. C., D'Amico, J. A., Itoua, I., Strand, H. E., Mo…

Optic Nerve Head Gene Transcription Sequelae to a Single Elevated IOP Exposure Provides Insights Into Known Responses to Chronically Elevated IOP Open

Diana C. Lozano, Hari Jayaram, William O. Cepurna, Shandiz Tehrani, Lina Gao , et al. · 2023

The PT-CEI model places in sequence ONH gene expression responses previously reported in models with chronically elevated IOP and may provide insights into their role in optic nerve damage.

Longitudinal Observation of Retinal Response to Optic Nerve Transection in Rats Using Visible Light Optical Coherence Tomography Open

Shaohua Pi, Bingjie Wang, Min Gao, William O. Cepurna, Diana C. Lozano , et al. · 2023

Vis-OCT can provide high-definition, in vivo characterization of retinal responses to ONT in rats. Despite a significant reduction in retinal layer thickness, this was not accompanied by alterations in vascular density. Despite this, oxime…

A method describing the microdissection of trabecular meshwork tissue from Brown Norway rat eyes Open

Eliesa Ing, Diana C. Lozano, William O. Cepurna, Fountane Chan, Yongfeng Yang , et al. · 2023

Uncontrolled Bleeding After Tongue Laceration Leading to a Difficult Airway in the Setting of Hemophilia A: A Case Report Open

Rebecca L. Siegel, Dalal Budri, John C. Morrison · 2022

Simultaneous Bilateral Ovarian Torsion in a Transgender Patient Open

Rasheeda Rickman, Alanna O’Connell, Meredith Jones, John C. Morrison · 2022

Ovarian torsions are a diagnostic challenge in the emergency room that result in significant morbidity when missed. Ovarian torsions have a low incidence and can present with atypical and variable symptoms. As such, recognition of ovarian …

Volume-based, layer-independent, disease-agnostic detection of abnormal retinal reflectivity, nonperfusion, and neovascularization using structural and angiographic OCT Open

Shaohua Pi, Tristan T. Hormel, Bingjie Wang, Steven T. Bailey, Thomas S. Hwang , et al. · 2022

Optical coherence tomography (OCT) is widely used in ophthalmic practice because it can visualize retinal structure and vasculature in vivo and 3-dimensionally (3D). Even though OCT procedures yield data volumes, clinicians typically inter…

Using the Conservation Standards Framework to Address the Effects of Climate Change on Biodiversity and Ecosystem Services Open

Marcia Brown, John C. Morrison, Terri T. Schulz, Molly S. Cross, Nicole Püschel-Hoeneisen , et al. · 2022

Climate change has challenged biodiversity conservation practitioners and planners. In this paper, we provide scalable guidance on integrating climate change into conservation planning and adaptive management that results in the most appro…

Probabilistic representations should be defined by their computational role: reply to Rahnev et al. 2021 Open

Raphael T. Gerraty, Samuel Lippl, John C. Morrison, Nikolaus Kriegeskorte · 2021

Note: This is a reply to the Generative Adversarial Collaboration "Is perception probabilistic? Clarifying the definitions" by Rahnev, Block, Denison, and Jehee (DOI 10.31234/osf.io/f8v5r). Probabilistic representations promise to shed lig…

Sickle cell disease Open

Marc Parrish, John C. Morrison · 2021

Sickle cell disease (SCD) refers to a group of autosomal recessive disorders involving abnormal hemoglobin. Crisis is associated with increased maternal and perinatal morbidity and mortality. Caution must be used when interpreting theresul…

Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure Open

Liang Liu, Hana L. Takusagawa, Miles F. Greenwald, Jie Wang, Brock Alonzo , et al. · 2021

Amniotic Fluid Volume Assessment: Eight Lessons Learned Open

Everett F. Magann, Julie R. Whittington, John C. Morrison, Suneet P. Chauhan · 2021

Actual AFV can be determined by a dye-dilution technique or be directly measured at cesarean. This allows investigators to correlate estimated and actual AFVs. Lessons learned by assessing the relationship of estimated to actual AFVs. 1) U…

An end-to-end network for segmenting the vasculature of three retinal capillary plexuses from OCT angiographic volumes Open

Yukun Guo, Tristan T. Hormel, Shaohua Pi, Xiang Wei, Min Gao , et al. · 2021

The segmentation of en face retinal capillary angiograms from volumetric optical coherence tomographic angiography (OCTA) usually relies on retinal layer segmentation, which is time-consuming and error-prone. In this study, we developed a …

PDB5 Determination of Payer Budget Impact from Using an Innovative in Vitro Diagnostic in the Management of Diabetic Kidney Disease Open

William Burchenal, Manasi Datar, Kirsten E. Peters, Gareth C. Fernandez, John C. Morrison , et al. · 2021

Focal Loss Analysis of Nerve Fiber Layer Reflectance for Glaucoma Diagnosis Open

Ou Tan, Qi Sheng You, Aiyin Chen, Eliesa Ing, John C. Morrison , et al. · 2021

Purpose: To evaluate nerve fiber layer (NFL) reflectance for glaucoma diagnosis. Methods: Participants were imaged with 4.5X4.5-mm volumetric disc scans using spectral-domain optical coherence tomography (OCT). The normalized NFL reflectan…

Individual-Specific Modeling of Rat Optic Nerve Head Biomechanics in Glaucoma Open

Stephen A. Schwaner, R. Noah Perry, Alison M. Kight, Emily Winder, Hongli Yang , et al. · 2020

Glaucoma is the second leading cause of blindness worldwide and is characterized by the death of retinal ganglion cells (RGCs), the cells that send vision information to the brain. Their axons exit the eye at the optic nerve head (ONH), th…

Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography Open

Tristan T. Hormel, Yali Jia, Yifan Jian, Thomas S. Hwang, Steven T. Bailey , et al. · 2020

In vivo retinal neuronal cells visualization with visible light OCT Open

Shaohua Pi, Tristan T. Hormel, Xiang Wei, William O. Cepurna, John C. Morrison , et al. · 2020

Blood Oxygen Saturation in Retinal Microcirculation Open

Shaohua Pi, Tristan T. Hormel, Xiang Wei, William O. Cepurna, Bingjie Wang , et al. · 2020

Time Course of Optic Nerve Head (ONH) Glia Proliferation following a Pulse-Train Controlled Elevation of IOP (PT-CEI) Open

Diana C. Lozano, Hailey Pausz, William O. Cepurna, Virginia O'Callahan, Susan Wentzien , et al. · 2020

Systemic Rho kinase inhibition protects optic nerve axons against acute intraocular pressure elevation through stabilization of astrocyte cytoskeleton and connexin43 gap junctions Open

Shandiz Tehrani, Katherine Delf, William O. Cepurna, Diana C. Lozano, Elaine C. Johnson , et al. · 2020

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