John C. Rasmussen
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View article: Additional evidence from a case report supports a novel hypothesis on the association between complex regional pain syndrome and lymphedema
Additional evidence from a case report supports a novel hypothesis on the association between complex regional pain syndrome and lymphedema Open
A previous report of 4 heterogeneous cases demonstrated that automated manual lymphatic drainage therapy (AMLDT), administered by a novel, pneumatic mat of 16 pressurized air channels that inflate and deflate sequentially to mimic the stre…
View article: Preclinical Evaluation of Closed Incisional Negative Pressure Therapy on Post‐Surgical Oedema and Lymphatic Activity
Preclinical Evaluation of Closed Incisional Negative Pressure Therapy on Post‐Surgical Oedema and Lymphatic Activity Open
Closed incisional Negative Pressure Therapy (ciNPT) has demonstrated improved post‐surgical healing with reduced oedema and hematoma/seroma formation in patients. The underlying mechanism of action is poorly understood, although evidence i…
View article: Case Report: The effect of automated manual lymphatic drainage therapy on lymphatic contractility in 4 distinct cases
Case Report: The effect of automated manual lymphatic drainage therapy on lymphatic contractility in 4 distinct cases Open
Introduction Automated manual lymphatic drainage therapy (AMLDT) is available for home use in the form of a pneumatic mat of 16 pressurized air channels that inflate and deflate to mimic the stretch and release action of manual lymphatic d…
View article: Near-Infrared Fluorescence Tomography and Imaging of Ventricular Cerebrospinal Fluid Flow and Extracranial Outflow in Non-Human Primates
Near-Infrared Fluorescence Tomography and Imaging of Ventricular Cerebrospinal Fluid Flow and Extracranial Outflow in Non-Human Primates Open
The role of the lymphatics in the clearance of cerebrospinal fluid (CSF) from the brain has been implicated in multiple neurodegenerative conditions. In premature infants, intraventricular hemorrhage causes increased CSF production and, if…
View article: Imaging peripheral lymphatic dysfunction in chronic conditions
Imaging peripheral lymphatic dysfunction in chronic conditions Open
The lymphatics play important roles in chronic diseases/conditions that comprise the bulk of healthcare worldwide. Yet the ability to routinely image and diagnose lymphatic dysfunction, using commonly available clinical imaging modalities,…
View article: Plasma Cytokines/Chemokines as Predictive Biomarkers for Lymphedema in Breast Cancer Patients
Plasma Cytokines/Chemokines as Predictive Biomarkers for Lymphedema in Breast Cancer Patients Open
Breast cancer-related lymphedema (BCRL) occurs in ~ 40% of patients after axillary lymph node dissection (ALND), radiation therapy (RT), or chemotherapy. First-line palliative treatment utilizes compression garments and specialized massage…
View article: Prediction of breast cancer-related lymphedema by dermal backflow detected with near-infrared fluorescence lymphatic imaging
Prediction of breast cancer-related lymphedema by dermal backflow detected with near-infrared fluorescence lymphatic imaging Open
View article: Lymphatic function and anatomy in early stages of lipedema
Lymphatic function and anatomy in early stages of lipedema Open
Objective Lipedema is an inflammatory subcutaneous adipose tissue disease that develops in women and may progress to lipolymphedema, a condition similar to lymphedema, in which lymphatic dysfunction results in irresolvable edema. Because i…
View article: Prediction of Breast Cancer-Related Lymphedema by Dermal Backflow Detected With Near-Infrared Fluorescence Lymphatic Imaging: Results of a Prospective, Longitudinal Cohort Study
Prediction of Breast Cancer-Related Lymphedema by Dermal Backflow Detected With Near-Infrared Fluorescence Lymphatic Imaging: Results of a Prospective, Longitudinal Cohort Study Open
View article: Lymphatic Dissemination and Axillary Web Syndrome in Primary Cutaneous Tuberculosis Secondary to Needlestick Injury
Lymphatic Dissemination and Axillary Web Syndrome in Primary Cutaneous Tuberculosis Secondary to Needlestick Injury Open
Cutaneous tuberculosis secondary to skin inoculation of Mycobacterium tuberculosis is uncommon but it can occur in the health care settings. Herein, we report an unusual case of primary cutaneous tuberculosis of the thumb following a needl…
View article: Multimodality lymphatic imaging of postoperative chylothorax in an infant with Noonan syndrome: a case report
Multimodality lymphatic imaging of postoperative chylothorax in an infant with Noonan syndrome: a case report Open
Background Chylothorax is a rare complication of pediatric cardiac operations that occurs more frequently in children with Noonan syndrome, a genetic disorder associated with cardiac defects and lymphatic anomalies. Case presentation We re…
View article: Degradation of lymphatic anatomy and function in early venous insufficiency
Degradation of lymphatic anatomy and function in early venous insufficiency Open
View article: The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors
The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors Open
Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may not always result in c…
View article: Assessing lymphatic route of CSF outflow and peripheral lymphatic contractile activity during head‐down tilt using near‐infrared fluorescence imaging
Assessing lymphatic route of CSF outflow and peripheral lymphatic contractile activity during head‐down tilt using near‐infrared fluorescence imaging Open
Evidence overwhelmingly suggests that the lymphatics play a critical role in the clearance of cerebrospinal fluid (CSF) from the cranial space. Impairment of CSF outflow into the lymphatics is associated with a number of pathological condi…
View article: Head and Neck Lymphedema: Treatment Response to Single and Multiple Sessions of Advanced Pneumatic Compression Therapy
Head and Neck Lymphedema: Treatment Response to Single and Multiple Sessions of Advanced Pneumatic Compression Therapy Open
Ten head and neck cancer survivors diagnosed with head and neck lymphedema (HNL) were imaged using near‐infrared fluorescence lymphatic imaging (NIRFLI) prior to and immediately after an initial advance pneumatic compression device treatme…
View article: Nanotopography-based lymphatic delivery for improved anti-tumor responses to checkpoint blockade immunotherapy
Nanotopography-based lymphatic delivery for improved anti-tumor responses to checkpoint blockade immunotherapy Open
Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against "self" antigens (Ags). In cancer, an…
View article: Near-infrared fluorescence lymphatic imaging of Klippel-Trénaunay syndrome
Near-infrared fluorescence lymphatic imaging of Klippel-Trénaunay syndrome Open
View article: Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis
Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis Open
View article: Near-Infrared Fluorescence Lymphatic Imaging of a Toddler With Congenital Lymphedema
Near-Infrared Fluorescence Lymphatic Imaging of a Toddler With Congenital Lymphedema Open
Primary lymphedema in the pediatric population remains poorly diagnosed and misunderstood due to a lack of information on the causation and underlying anatomy of the lymphatic system. Consequently, therapeutic protocols for pediatric patie…
View article: Effect of pneumatic compression therapy on lymph movement in lymphedema-affected extremities, as assessed by near-infrared fluorescence lymphatic imaging
Effect of pneumatic compression therapy on lymph movement in lymphedema-affected extremities, as assessed by near-infrared fluorescence lymphatic imaging Open
Previous studies have shown cost effectiveness and quality-of-life benefit of pneumatic compression therapy (PCT) for lymphedema (LE). Insurers, such as the Centers for Medicare/Medicaid (CMS), however, desire visual proof that PCT moves l…
View article: Dermal Backflow Seen Through Near-Infrared Fluorescence Imaging: An Early Response to Cancer Treatments in Head and Neck for the Detection of Lymphedema
Dermal Backflow Seen Through Near-Infrared Fluorescence Imaging: An Early Response to Cancer Treatments in Head and Neck for the Detection of Lymphedema Open
View article: A novel mutation in CELSR1 is associated with hereditary lymphedema
A novel mutation in CELSR1 is associated with hereditary lymphedema Open
CELSRI may be responsible for primary, non-syndromic lymphedema in humans.
View article: Determining the Performance of Fluorescence Molecular Imaging Devices Using Traceable Working Standards With SI Units of Radiance
Determining the Performance of Fluorescence Molecular Imaging Devices Using Traceable Working Standards With SI Units of Radiance Open
To date, no emerging preclinical or clinical near-infrared fluorescence (NIRF) imaging devices for noninvasive and/or surgical guidance have their performances validated on working standards with SI units of radiance that enable comparison…
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View article: Near-Infrared Fluorescence Lymphatic Imaging in Lymphangiomatosis
Near-Infrared Fluorescence Lymphatic Imaging in Lymphangiomatosis Open
Further research into anatomical and functional lymphatic changes associated with the progression and treatment of lymphangiomatosis could aid in understanding the pathophysiology of the disease as well as point to treatment strategies.
View article: Near-infrared fluorescence lymphatic imaging in a patient treated for venous occlusion
Near-infrared fluorescence lymphatic imaging in a patient treated for venous occlusion Open
Although lower extremity edema/lymphedema can result from venous and/or lymphatic abnormalities, effective treatment depends upon understanding their relative contributions to the condition. Herein we use near-infrared fluorescence lymphat…
View article: Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression
Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression Open