John C. Salerno
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View article: MAP kinases differentially bind and phosphorylate NOS3 via two unique NOS3 sites
MAP kinases differentially bind and phosphorylate NOS3 via two unique NOS3 sites Open
Nitric oxide synthase 3 (NOS3) is a major vasoprotective enzyme that catalyzes the conversion of l ‐arginine to nitric oxide (NO) in response to a significant number of signaling pathways. Here, we provide evidence that NOS3 interactions w…
View article: Control of eNOS and nNOS through regulation of obligatory conformational changes in the reductase catalytic cycle
Control of eNOS and nNOS through regulation of obligatory conformational changes in the reductase catalytic cycle Open
Endothelial and neuronal nitric oxide synthases (eNOS, nNOS) are important signal generators in a number of processes including angiogenesis and neurotransmission. The homologous inducible isoform (iNOS) occupies a multitude of conformatio…
View article: Novel cell-penetrating peptide-adaptors effect intracellular delivery and endosomal escape of protein cargos
Novel cell-penetrating peptide-adaptors effect intracellular delivery and endosomal escape of protein cargos Open
The use of cell-penetrating peptides (CPPs) as biomolecular delivery vehicles holds great promise for therapeutic and other applications, but development has been stymied by poor delivery and lack of endosomal escape. We have developed a C…