John Cafardi
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View article: Single cell RNA transcriptome response to fentanyl use in persons with hepatitis C virus infection
Single cell RNA transcriptome response to fentanyl use in persons with hepatitis C virus infection Open
Introduction The US has experienced a major drug epidemic in recent years, attributed in large part to synthetic opioids such as fentanyl. Here, we evaluated how recreational / non-prescribed fentanyl use in persons living with HCV infecti…
View article: Vertical Transmission of Hepatitis C Virus Among Women With a History of Injection Opioid Use
Vertical Transmission of Hepatitis C Virus Among Women With a History of Injection Opioid Use Open
We evaluated vertical transmission and linkage to care in women with hepatitis C virus (HCV) and history of injection drug use employing co-localized testing and treatment. Transmission occurred in 1 of 23 infants, with mother-infant genet…
View article: Phase 1 study of safety, pharmacokinetics, and antiviral activity of <scp>SARS‐CoV</scp>‐2 neutralizing monoclonal antibody <scp>ABBV‐47D11</scp> in patients with <scp>COVID</scp>‐19
Phase 1 study of safety, pharmacokinetics, and antiviral activity of <span>SARS‐CoV</span>‐2 neutralizing monoclonal antibody <span>ABBV‐47D11</span> in patients with <span>COVID</span>‐19 Open
ABBV‐47D11 is a neutralizing monoclonal antibody that targets a mutationally conserved hydrophobic pocket distal to the ACE2 binding site of SARS‐CoV‐2. This first‐in‐human safety, pharmacokinetics, and antiviral pharmacodynamic assessment…
View article: Efficacy and Safety of Pacritinib vs Placebo for Patients With Severe COVID-19
Efficacy and Safety of Pacritinib vs Placebo for Patients With Severe COVID-19 Open
Importance The morbidity and mortality associated with COVID-19 remain high despite advances in standard of care therapy, and the role of anti-inflammatory agents that inhibit the interleukin 6/JAK2 pathway is still being elucidated. Objec…
View article: Opportunistic Fungal Infection Associated With COVID-19
Opportunistic Fungal Infection Associated With COVID-19 Open
We report 2 cases of severe coronavirus disease 2019 requiring prolonged hospitalization complicated by the late onset of opportunistic fungal infections, histoplasmosis, and cryptococcosis.
View article: Chronic Liver Disease and COVID‐19: Alcohol Use Disorder/Alcohol‐Associated Liver Disease, Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Autoimmune Liver Disease, and Compensated Cirrhosis
Chronic Liver Disease and COVID‐19: Alcohol Use Disorder/Alcohol‐Associated Liver Disease, Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Autoimmune Liver Disease, and Compensated Cirrhosis Open
Potential conflict of interest: J.C. advises and received grants from Gilead. Because between 1% and 11% of patients with Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection may have chronic liver disease,1,2 understandi…
View article: Brucella Endocarditis in Persons Who Inject Drugs
Brucella Endocarditis in Persons Who Inject Drugs Open
We report 2 cases of infective endocarditis in injection drug users due to Brucella infection. Although cardiac involvement is a frequent sequela of brucellosis and endocarditis is often seen with injection drug use, Brucella endocarditis …
View article: 565. Implementing HIV Rapid Entry in a Community Infectious Disease Practice
565. Implementing HIV Rapid Entry in a Community Infectious Disease Practice Open
BACKGROUND: Successful achievement of “90-90-90” HIV care continuum goals depends on increasing diagnosis, linkage to care, and treatment initiation. Recent improvement efforts include immediate linkage and antiretroviral (ARV) therapy acc…
View article: Microbiological profile and risk factors for in-hospital mortality of infective endocarditis in tertiary care hospitals of south Vietnam
Microbiological profile and risk factors for in-hospital mortality of infective endocarditis in tertiary care hospitals of south Vietnam Open
Streptococcal species were the major pathogen of IE in the recent years with low rates of antimicrobial resistance. Prosthetic valve involvement, moderate or severe heart failure and vegetation size of more than 15 mm were independent pred…