John Cafferkey
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View article: Intubation aids in hyperangulated videolaryngoscopy: essential components more than just adjuncts
Intubation aids in hyperangulated videolaryngoscopy: essential components more than just adjuncts Open
We read with interest the study by Eum et al. [1], which compares performance of airway adjuncts for facilitating tracheal intubation using hyperangulated videolaryngoscopy in patients with predicted difficulty. We welcome research in this…
View article: Albumin versus Balanced Crystalloid for the early resuscitation of sepsis: a randomised feasibility trial. The ABC-Sepsis Trial.
Albumin versus Balanced Crystalloid for the early resuscitation of sepsis: a randomised feasibility trial. The ABC-Sepsis Trial. Open
Purpose International guidelines recommend intravenous crystalloid as the primary fluid for sepsis resuscitation, with 5% human albumin solution (HAS) as second line. However, it is unclear which fluid has superior clinical effectiveness. …
View article: Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus Open
Objectives Motor neuron disease (MND) is an incurable progressive neurodegenerative disease with limited treatment options. There is a pressing need for innovation in identifying therapies to take to clinical trial. Here, we detail a syste…
View article: Interferon-γ release assay screening in biologics: safe and reliable, but not perfect
Interferon-γ release assay screening in biologics: safe and reliable, but not perfect Open
Background Systemic biologic agents can increase the risk of re-activation of latent tuberculosis (TB). Prior to initiation, screening for latent TB using an interferon-γ release assay (IGRA) is recommended. There is concern that false-neg…
View article: Pulmonary embolism diagnosis part 1: clinical assessment at the front door
Pulmonary embolism diagnosis part 1: clinical assessment at the front door Open
This first of two practice reviews addresses pulmonary embolism (PE) diagnosis considering important aspects of PE clinical presentation and comparing evidence-based PE testing strategies. A companion paper addresses the management of PE. …
View article: Albumin versus balanced crystalloid for resuscitation in the treatment of sepsis: A protocol for a randomised controlled feasibility study, “ABC-Sepsis”
Albumin versus balanced crystalloid for resuscitation in the treatment of sepsis: A protocol for a randomised controlled feasibility study, “ABC-Sepsis” Open
Background Patients presenting with suspected sepsis to secondary care often require fluid resuscitation to correct hypovolaemia and/or septic shock. Existing evidence signals, but does not demonstrate, a benefit for regimes including albu…
View article: A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease
A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease Open
Background Motor neuron disease (MND) is an incurable progressive neurodegenerative disease with limited treatment options. There is a pressing need for innovation in identifying therapies to take to clinical trial. Objectives Here we deta…
View article: Pulmonary embolism management in the emergency department: part 2
Pulmonary embolism management in the emergency department: part 2 Open
Pulmonary embolism (PE) can present with a range of severity. Prognostic risk stratification is important for efficacious and safe management. This second of two review articles discusses the management of high-, intermediate- and low-risk…
View article: Open extent IV thoracoabdominal aneurysm repair: 22-year experience of the Scottish National Service
Open extent IV thoracoabdominal aneurysm repair: 22-year experience of the Scottish National Service Open
Background Since 1999, the Scottish National Service for Thoracoabdominal Aneurysms has offered repair of thoracoabdominal aneurysms (TAAAs) to a population of 5.5 million people. The open operation most commonly performed by the service i…
View article: Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections
Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections Open
James A Coultas, 1 John Cafferkey, 2 Patrick Mallia, 1 Sebastian L Johnston 1 1National Heart and Lung Institute, Imperial College London, London, UK; 2Respiratory Medicine, St Mary’s Hospital, Imperial College Healthcare Foundation Trust,…
View article: Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections
Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections Open
Rhinovirus infection is common and usually causes mild, self-limiting upper respiratory tract symptoms. Rhinoviruses can cause exacerbation of chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease, leading t…
View article: Review: The Nose as a Route for Therapy. Part 2 Immunotherapy
Review: The Nose as a Route for Therapy. Part 2 Immunotherapy Open
The nose provides a route of access to the body for inhalants and fluids. Unsurprisingly it has a strong immune defense system, with involvement of innate (e.g., epithelial barrier, muco- ciliary clearance, nasal secretions with interferon…
View article: Contributor Biographies
Contributor Biographies Open
Economic Ideas in the Interwar British Daily Press', at the same institution.He is currently working on a reappraisal of the Empire Crusade campaign and a survey of how
View article: Factors associated with reattendance to emergency services following COVID‐19 hospitalization
Factors associated with reattendance to emergency services following COVID‐19 hospitalization Open
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View article: Use of the HoloLens2 Mixed Reality Headset for Protecting Health Care Workers During the COVID-19 Pandemic: Prospective, Observational Evaluation
Use of the HoloLens2 Mixed Reality Headset for Protecting Health Care Workers During the COVID-19 Pandemic: Prospective, Observational Evaluation Open
Background The coronavirus disease (COVID-19) pandemic has led to rapid acceleration in the deployment of new digital technologies to improve both accessibility to and quality of care, and to protect staff. Mixed-reality (MR) technology is…
View article: Using HoloLens2™ to reduce staff exposure to aerosol generating procedures during a global pandemic
Using HoloLens2™ to reduce staff exposure to aerosol generating procedures during a global pandemic Open
RATIONALE COVID-19 poses a unique challenge; caring for patients with a novel, infectious disease whilst protecting staff. Some interventions used to give oxygen therapy are aerosol generating procedures. Staff delivering such intervention…