John M. Carney
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View article: Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage
Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage Open
Anthrax represents a disease resulting from infection by toxin-secreting bacteria, Bacillus anthracis. This research aimed to identify new therapeutic targets to combat anthrax. We performed assays to assess cell viability, apoptosis, glyc…
View article: An Immunogenic and Slow-Growing Cryptococcal Strain Induces a Chronic Granulomatous Infection in Murine Lungs
An Immunogenic and Slow-Growing Cryptococcal Strain Induces a Chronic Granulomatous Infection in Murine Lungs Open
Many successful pathogens cause latent infections, remaining dormant within the host for years but retaining the ability to reactivate to cause symptomatic disease. The human opportunistic fungal pathogen Cryptococcus neoformans establishe…
View article: Comparison of Forceps, Cryoprobe, and Thoracoscopic Lung Biopsy for the Diagnosis of Interstitial Lung Disease − The CHILL Study
Comparison of Forceps, Cryoprobe, and Thoracoscopic Lung Biopsy for the Diagnosis of Interstitial Lung Disease − The CHILL Study Open
Rationale: Transbronchial lung cryobiopsy (TBLC) has emerged as a less invasive method to obtain a tissue diagnosis in patients with interstitial lung disease (ILD). The diagnostic yield of TBLC compared to surgical lung biopsy (SLB) remai…
View article: A hyper-immunogenic and slow-growing fungal strain induces a murine granulomatous response to cryptococcal infection
A hyper-immunogenic and slow-growing fungal strain induces a murine granulomatous response to cryptococcal infection Open
Many successful pathogens cause latent infections, remaining dormant within the host for years but retaining the ability to reactivate to cause symptomatic disease. The human opportunistic pathogen Cryptococcus neoformans is a ubiquitous y…
View article: Parenteral administration of oral medications in lung transplant recipients: An underrecognized problem
Parenteral administration of oral medications in lung transplant recipients: An underrecognized problem Open
Microcrystalline cellulose (MCC) is an insoluble material commonly used as a binder and filler in oral medications. Identification of pulmonary intravascular deposition of MCC in transbronchial biopsies from lung transplant (LT) recipients…
View article: Novel intronic <i>DICER1</i> variation associated with pleuropulmonary blastoma in two siblings
Novel intronic <i>DICER1</i> variation associated with pleuropulmonary blastoma in two siblings Open
Pleuropulmonary blastomas (PPB) are rare aggressive paediatric lung malignancies associated with DICER1 variants. We present two cases, a 2-year-old girl with upper respiratory tract symptoms as well as a 6-month-old girl sibling undergoin…
View article: Large mesenteric lymphangioma in an adult patient: an unusual presentation of a rare disease
Large mesenteric lymphangioma in an adult patient: an unusual presentation of a rare disease Open
Lymphangiomas are most commonly described as a small painless mass in the neck or a vesicular rash in an infant patient. Ninety per cent of cases are diagnosed before the age of 2. Treatment usually involves surgical resection. Intra-abdom…
View article: Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice
Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice Open
The gene KRAS is commonly mutated in lung cancer to encode a constitutively active and oncogenic protein that is well established to initiate and maintain lung tumorigenesis. However, the remaining wild-type KRAS protein, or the other fami…