J. Jeffrey Carr
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View article: Multimodal Cardiac Imaging of Immune‐Mediated Complications Post Heart Transplantation: A Contemporary Review
Multimodal Cardiac Imaging of Immune‐Mediated Complications Post Heart Transplantation: A Contemporary Review Open
Heart transplantation significantly enhances survival and quality of life for patients with end‐stage heart failure. Despite advances in surgical and postoperative care, immune‐mediated complications, acute graft rejection and cardiac allo…
View article: Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis.
Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis. Open
View article: An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy
An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy Open
The high burden of dilated cardiomyopathy (DCM) in individuals of African descent remains incompletely explained. Here, to explore a genetic basis, we conducted a genome-wide association study in 1,802 DCM cases and 93,804 controls of Afri…
View article: Pulmonary Artery Size on CT Associates with Mean Pulmonary Artery Pressure and Mortality
Pulmonary Artery Size on CT Associates with Mean Pulmonary Artery Pressure and Mortality Open
In subjects without significant lung disease outside of PH, PA size on CT was associated with increased mPAP and decreased transplant-free survival across the spectrum of PH severity and demonstrated modest diagnostic discriminatory abilit…
View article: Coffee consumption and calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study
Coffee consumption and calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study Open
View article: Sugar-Sweetened Beverage Consumption and Calcified Atherosclerotic Plaques in the Coronary Arteries: The NHLBI Family Heart Study
Sugar-Sweetened Beverage Consumption and Calcified Atherosclerotic Plaques in the Coronary Arteries: The NHLBI Family Heart Study Open
BACKGROUND: Sugar-sweetened beverage (SSB) intake is associated with higher risk of weight gain, diabetes, hypertension, cardiovascular disease, and cardiovascular mortality. However, the association of SSB with subclinical atherosclerosis…
View article: Cardiometabolic Health and Bariatric Surgery: A 25-Year Longitudinal Cohort Study in CARDIA Participants
Cardiometabolic Health and Bariatric Surgery: A 25-Year Longitudinal Cohort Study in CARDIA Participants Open
Objective: Compare longitudinal cardiometabolic health outcomes among individuals who underwent bariatric surgery (BarS) with nonsurgical controls. Background: BarS is well-established for inducing profound weight loss and improving cardio…
View article: No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study
No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study Open
Background Artificial sweeteners have become ubiquitous additives in the food supply, and yet the safety of their regular consumption remains controversial. The present study examined whether intakes of aspartame or saccharin are related t…
View article: Human Physiologic Responses to Insulin in Indigenous Americans Identify a Metabolic Susceptibility Profile Linked to Diabetes
Human Physiologic Responses to Insulin in Indigenous Americans Identify a Metabolic Susceptibility Profile Linked to Diabetes Open
OBJECTIVE To identify metabolic signatures of insulin action/secretion in Indigenous Americans (IAs) and their association with diabetes. RESEARCH DESIGN AND METHODS We defined circulating metabolomic signatures of insulin action/secretion…
View article: Human physiologic responses to insulin in Indigenous Americans identify a metabolic susceptibility profile linked to diabetes
Human physiologic responses to insulin in Indigenous Americans identify a metabolic susceptibility profile linked to diabetes Open
Objective: To identify a metabolic signature of insulin action/secretion in Indigenous Americans (IAs) and its association with diabetes. Research Design and Methods: We defined circulating metabolomic signatures of insulin action/secretio…
View article: Human physiologic responses to insulin in Indigenous Americans identify a metabolic susceptibility profile linked to diabetes
Human physiologic responses to insulin in Indigenous Americans identify a metabolic susceptibility profile linked to diabetes Open
Objective: To identify a metabolic signature of insulin action/secretion in Indigenous Americans (IAs) and its association with diabetes. Research Design and Methods: We defined circulating metabolomic signatures of insulin action/secretio…
View article: Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults
Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults Open
INTRODUCTION More intermuscular fat (IMF) has been associated with lower cognitive performance through mechanisms that are not fully elucidated. METHODS The associations of 7628 plasma proteins with IMF were assessed in the Baltimore Longi…
View article: Cumulative Lipids Exposure Through Young Adulthood and Metabolic Dysfunction-Associated Steatotic Liver Disease in Midlife
Cumulative Lipids Exposure Through Young Adulthood and Metabolic Dysfunction-Associated Steatotic Liver Disease in Midlife Open
View article: Corrigendum to “Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden” [American Journal of Preventive Cardiology 21 (2025) 100916]
Corrigendum to “Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden” [American Journal of Preventive Cardiology 21 (2025) 100916] Open
[This corrects the article DOI: 10.1016/j.ajpc.2024.100916.].
View article: Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study
Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study Open
Rationale: Increased risk of coronavirus disease (COVID-19) hospitalization and death has been reported among patients with clinical lung disease. Objective: To test the association of objective measures of prepandemic lung f…
View article: Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness
Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness Open
Carotid artery intima-media thickness (cIMT) is a measurement of subclinical atherosclerosis that predicts future cardiovascular events, including stroke and myocardial infarction. Genome-wide association studies (GWAS) have identified onl…
View article: Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk
Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk Open
Background Previous work has shown a role of CCL2, a key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor of CCL2, provides protection against human athe…
View article: Molecular architecture of human atherosclerosis revealed through integrative human genetics
Molecular architecture of human atherosclerosis revealed through integrative human genetics Open
Current genetic discovery methods are largely restricted to profiling circulating molecules or genetic architecture, limited in use of tissue-based molecular genetics to identify pathogenic and therapeutic targets. Here, we leverage a mult…
View article: The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies
The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies Open
Introduction Human immunodeficiency virus (HIV) infection is linked to myocardial fibrosis. Observational studies using cardiac magnetic resonance (CMR) have explored this relationship but scarcity of data synthesis limits our understandin…
View article: Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults
Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults Open
INTRODUCTION More intermuscular fat (IMF) has been associated with lower cognitive performance and faster age-associated decline in cognitive function however, the mechanisms driving this relationship have not been fully elucidated. We uti…
View article: Abdominal Myosteatosis and Cognitive Decline in a Biracial Cohort: Insights from CARDIA Study
Abdominal Myosteatosis and Cognitive Decline in a Biracial Cohort: Insights from CARDIA Study Open
Objective Skeletal muscle fat infiltration (myosteatosis) increases with age and is an emerging risk factor for dementia. We aimed to determine the association between myosteatosis and cognitive decline among middle-aged White and Black Am…
View article: Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden
Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden Open
View article: Multiparametric cardiac MRI for detection and grading of cardiac allograft vasculopathy in heart transplant recipients: A machine learning approach
Multiparametric cardiac MRI for detection and grading of cardiac allograft vasculopathy in heart transplant recipients: A machine learning approach Open
View article: Validation of normal reference ranges in cardiac magnetic resonance imaging: The Multi-Ethnic Study of Atherosclerosis
Validation of normal reference ranges in cardiac magnetic resonance imaging: The Multi-Ethnic Study of Atherosclerosis Open
Our results support the clinical relevance of CMR normal reference ranges for LV parameters. Most LV CMR parameters beyond the normal reference range (2SD-threshold) were associated with elevated CV risk at 5 and 10 years. Elevated LVEDDi,…
View article: Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis
Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis Open
SUMMARY Epitranscriptomic modifications on RNA play critical roles in stability, processing, and function, partly by influencing interactions with RNA-binding proteins and receptors. The role of post-transcriptional RNA modifications on ce…
View article: A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver
A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver Open
View article: The Primacy of Adipose Tissue Gene Expression and Plasma Lipidome in Cardiometabolic Disease in Persons With HIV
The Primacy of Adipose Tissue Gene Expression and Plasma Lipidome in Cardiometabolic Disease in Persons With HIV Open
Background Persons with HIV (PWH) on contemporary antiretroviral therapy (ART) are at elevated risk for developing age-related cardiometabolic diseases. We hypothesized that integrative analysis of cross-tissue, multimodal data from PWH co…
View article: ABDOMINAL MYOSTEATOSIS AND COGNITIVE FUNCTION: INSIGHTS FROM CARDIA STUDY
ABDOMINAL MYOSTEATOSIS AND COGNITIVE FUNCTION: INSIGHTS FROM CARDIA STUDY Open
The role of myosteatosis in cognitive decline is largely from cross-sectional studies in White populations. Longitudinal studies including Black populations, who have a higher risk of both myosteatosis and dementia than Whites, are warrant…
View article: A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver
A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver Open
View article: Lung structure and longitudinal change in cardiac structure and function: the MESA COPD Study
Lung structure and longitudinal change in cardiac structure and function: the MESA COPD Study Open
Background Lung structure and cardiac structure and function are associated cross-sectionally. The classic literature suggests relationships of airways disease to cor pulmonale and emphysema to reduced cardiac output (CO) but longitudinal …