Fergus Caskey
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View article: How do older patients with advanced kidney disease, and their family members, understand kidney function and failure? A qualitative study
How do older patients with advanced kidney disease, and their family members, understand kidney function and failure? A qualitative study Open
Background Patients approaching kidney failure are increasingly older, and living with multiple long-term conditions. The benefits of kidney replacement therapy (KRT) are uncertain for many in this group. Supporting decisions between treat…
View article: Examining the pathway to specialist care for children and young people with late presentation of chronic kidney disease in the UK: a qualitative study
Examining the pathway to specialist care for children and young people with late presentation of chronic kidney disease in the UK: a qualitative study Open
Objective Detecting chronic kidney disease (CKD) early can provide opportunities to optimise native kidney function, prevent further decline and plan for timely kidney transplantation if required. Understanding how children are found to ha…
View article: A pragmatic, randomised, open-label, multi-centre UK registry-facilitated trial evaluating the effect of high-dose cholecalciferol on mortality in patients on dialysis: the SIMPLIFIED trial
A pragmatic, randomised, open-label, multi-centre UK registry-facilitated trial evaluating the effect of high-dose cholecalciferol on mortality in patients on dialysis: the SIMPLIFIED trial Open
Background Vitamin D deficiency is common in patients with end stage kidney disease (ESKD) and is a strong predictor of death from cardiovascular disease, infections and cancer. Currently only 68% of patients in the UK survive 3 years or m…
View article: Protein carbamylation is associated with increased mortality and CKD progression in patients with CKD: results from the EQUAL study
Protein carbamylation is associated with increased mortality and CKD progression in patients with CKD: results from the EQUAL study Open
Background and hypothesis Urea accumulated in CKD patients’ blood can spontaneously decompose into reactive isocyanate and bind to plasma proteins in a reaction called carbamylation. Recent studies suggest a direct link between protein car…
View article: Wider stakeholders’ perspectives on what is needed to implement electronic patient-reported outcome systems across UK kidney healthcare organisations: a qualitative study
Wider stakeholders’ perspectives on what is needed to implement electronic patient-reported outcome systems across UK kidney healthcare organisations: a qualitative study Open
Background: Implementing large scale electronic patient-reported outcome (ePRO) systems into clinical pathways requires these systems to cross the organisational boundaries of healthcare providers. Doing this successfully requires involvin…
View article: How are treatment decisions for myocardial infarction made in the presence of advanced kidney disease? A qualitative study in the UK
How are treatment decisions for myocardial infarction made in the presence of advanced kidney disease? A qualitative study in the UK Open
Objectives To understand why patients with chronic kidney disease (CKD) may not be treated according to international guidelines for myocardial infarction (MI). Design Multicentre qualitative interview study. Interviews were analysed using…
View article: #1318 Burden of pruritus in older CKD stage 4-5 patients: 7-year follow-up of the EQUAL study
#1318 Burden of pruritus in older CKD stage 4-5 patients: 7-year follow-up of the EQUAL study Open
Background and Aims Chronic kidney disease-associated pruritus (CKD-aP) is ranked within the top 10 most prevalent and burdensome symptoms in patients with kidney failure. CKD-aP is associated with reduced quality of life (QoL), psychologi…
View article: Association of autosomal dominant polycystic kidney disease (ADPKD) with cardiovascular disease and mortality in patients with treated kidney failure
Association of autosomal dominant polycystic kidney disease (ADPKD) with cardiovascular disease and mortality in patients with treated kidney failure Open
Introduction Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem syndrome associated with significant morbidity and mortality, particularly kidney failure. This study sought to evaluate mortality and transplant outcomes i…
View article: Causal assessment of CKD-MBD biomarker alterations on CKD progression through a g-formula analysis in the EQUAL study
Causal assessment of CKD-MBD biomarker alterations on CKD progression through a g-formula analysis in the EQUAL study Open
Among older men and women with advanced CKD not receiving dialysis, the presence of hyperphosphatemia, especially when combined with hypocalcemia and hyperparathyroidism, leads to an increased risk of CKD progression.
View article: How Do Older Patients With Advanced Kidney Disease, and Their Family Members, Understand Kidney Function and Failure? A Qualitative Study
How Do Older Patients With Advanced Kidney Disease, and Their Family Members, Understand Kidney Function and Failure? A Qualitative Study Open
Background Patients approaching kidney failure are increasingly older, and living with multiple long-term conditions. The benefits of kidney replacement therapy (KRT) are uncertain for many in this group. Supporting decisions between treat…
View article: Risk communication during treatment decision-making conversations with older people with advanced kidney disease
Risk communication during treatment decision-making conversations with older people with advanced kidney disease Open
Findings demonstrate how clinicians can convey information to patients about the risks of dialysis in advanced kidney disease to enable patients to recognise and consider CKM as a valid option.
View article: ‘That’s why I wanted him to go on dialysis’ – a qualitative inductive thematic analysis of older patients’ and their family members’ perspectives on kidney failure treatment decision-making
‘That’s why I wanted him to go on dialysis’ – a qualitative inductive thematic analysis of older patients’ and their family members’ perspectives on kidney failure treatment decision-making Open
Background Chronic kidney disease (CKD) is increasingly common amongst frail older patients with multiple health problems. These patients typically decide between kidney replacement therapy (KRT) with dialysis, which carries uncertain surv…
View article: BioImpedance Spectroscopy to maintain Renal Output: the BISTRO randomised controlled trial
BioImpedance Spectroscopy to maintain Renal Output: the BISTRO randomised controlled trial Open
Background Fluid removal is a key component of dialysis treatment but, if excessive, can result in a faster decline in residual kidney function. Prescribing the optimal removal of fluid on dialysis to avoid this is therefore important. Bio…
View article: Variation in Management of CKD-Associated Pruritus: Results From a Multinational Survey of Kidney Units
Variation in Management of CKD-Associated Pruritus: Results From a Multinational Survey of Kidney Units Open
There is considerable variation in the management of CKDaP. Unexplained clinical variation suggests a need for the development of evidence-based guidelines and additional high-quality studies to inform care.
View article: How do patient information documents present dialysis and conservative kidney management? A document analysis
How do patient information documents present dialysis and conservative kidney management? A document analysis Open
Background Most older people with advanced kidney disease face a decision between conservative kidney management (CKM) or dialysis and must weigh their potential benefits, risks and impacts on quality and length of life. Patient informatio…
View article: ‘<i>That’s why I wanted him to go on dialysis</i>’ – a qualitative inductive thematic analysis of older patients’ and their family members’ perspectives on kidney failure treatment decision-making
‘<i>That’s why I wanted him to go on dialysis</i>’ – a qualitative inductive thematic analysis of older patients’ and their family members’ perspectives on kidney failure treatment decision-making Open
Background Chronic kidney disease (CKD) is increasingly common amongst frail older patients with multiple health problems. These patients typically decide between kidney replacement therapy (KRT) with dialysis, which carries uncertain surv…
View article: Predicting Hospitalization and Related Outcomes in Advanced Chronic Kidney Disease: A Systematic Review, External Validation, and Development Study
Predicting Hospitalization and Related Outcomes in Advanced Chronic Kidney Disease: A Systematic Review, External Validation, and Development Study Open
Hospitalizations are important but difficult to predict for patients with advanced CKD. An improved prediction model should be developed, for example, using a more specific outcome (eg, cardiovascular hospitalizations) and more predictors …
View article: Maintaining kidney health in aging societies: a JSN and ERA call to action
Maintaining kidney health in aging societies: a JSN and ERA call to action Open
Chronic kidney disease (CKD) is the fastest growing cause of death, expected to become the fifth global cause of death and the third in some countries with long life expectancy, such as Japan and Spain, by 2050. This reflects societal agin…
View article: Cardiometabolic protein expression levels and pathways associated with kidney function decline in older European adults with advanced kidney disease
Cardiometabolic protein expression levels and pathways associated with kidney function decline in older European adults with advanced kidney disease Open
Background Cardiovascular disease and chronic kidney disease (CKD) progression pathophysiology are similar. We investigated associations of cardiometabolic protein expression and pathways with kidney function decline in older adults with a…
View article: ‘It’s basically ‘have that or die’’: a qualitative study of older patients’ choices between dialysis and conservative kidney management
‘It’s basically ‘have that or die’’: a qualitative study of older patients’ choices between dialysis and conservative kidney management Open
Objectives Older people with kidney failure often have a limited range of treatment options, with few being well enough to receive a transplant. Instead, they either start dialysis or have ‘conservative kidney management’ (CKM). CKM involv…
View article: Identifying children who develop severe chronic kidney disease using primary care records
Identifying children who develop severe chronic kidney disease using primary care records Open
Background Understanding whether symptoms suggestive of chronic kidney disease (CKD) are reported to primary care before diagnosis may provide opportunities for earlier detection, thus supporting strategies to prevent progression and impro…
View article: Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA
Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA Open
A core feature of universal health coverage is equitable access to affordable care not exposing people to financial hardship. This study aims to provide a global overview on availability and access to medications and health technologies fo…