John C. Cheronis
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View article: A novel gene expression profiling system using quantitative PCR. For clinical research and drug development.
A novel gene expression profiling system using quantitative PCR. For clinical research and drug development. Open
Innovation of gene technologies such as DNA microarray and real-time PCR has made it possible to quantitatively measure the expression of multiple genes. Such new technologies are expected to advance clinical medicine and pave new avenues …
View article: Development of Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase
Development of Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase Open
5-Amino-2-phenylpyrimidin-6-ones, some of their desamino derivatives, and miscellaneous derivatives were synthesized and biologically evaluated on both in vitro activity and oral activity in an acute hemorrhagic assay. These compounds cont…
View article: Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase
Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase Open
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDesign and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil ElastaseKazuyuki Ohmoto, Tetsuya Yamamoto, Toshihide Horiuchi, Hirotoshi Imanishi, Yoshihiko Odagaki, Kazuhito …
View article: Purification and characterization of a novel zinc-proteinase from cultures of Aeromonas hydrophila.
Purification and characterization of a novel zinc-proteinase from cultures of Aeromonas hydrophila. Open
While searching for an enzyme capable of breaking epsilon-(gamma-Glu)-Lys isopeptide bonds cross-linking protein chains, we purified a metallo-proteinase which mimics the action of an isopeptidase on the gamma-chain dimers of cross-linked …
View article: Inhibition of human leucocyte elastase by ursolic acid. Evidence for a binding site for pentacyclic triterpenes
Inhibition of human leucocyte elastase by ursolic acid. Evidence for a binding site for pentacyclic triterpenes Open
Several pentacyclic triterpenoid metabolites of plant origin are inhibitors of hydrolysis of both synthetic peptide substrates and elastin by human leucocyte elastase (HLE). Ursolic acid, the most potent of these compounds, has an inhibiti…