John Roberts
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View article: A causal model for predicting the impact of pharmacotherapy on colorectal surgery outcomes
A causal model for predicting the impact of pharmacotherapy on colorectal surgery outcomes Open
Introduction Evidence‐based principles in enhanced recovery programs (ERPs) demonstrate substantial improvement in patient outcomes. Determining which latent variables predict composite outcomes could refine ERP pharmacotherapy recommendat…
View article: Ode to Science: With Eternal Thanks to Rudyard Kipling
Ode to Science: With Eternal Thanks to Rudyard Kipling Open
If you can keep your head when all about you Are losing theirs and blaming it on you. If you can trust yourself when all men doubt you But make allowance for their doubting too. If you can wait but not be tired by waiting And yet don't loo…
View article: Effect of CSL112 (apolipoprotein A‐I [human]) on cholesterol efflux capacity in Japanese subjects: Findings from a phase I study and a cross‐study comparison
Effect of CSL112 (apolipoprotein A‐I [human]) on cholesterol efflux capacity in Japanese subjects: Findings from a phase I study and a cross‐study comparison Open
CSL112 (apolipoprotein A‐I [apoA‐I, human]) is a novel drug in development to reduce the risk of recurrent cardiovascular events following acute myocardial infarction by increasing cholesterol efflux capacity (CEC). This phase I study aime…
View article: A systems pharmacology model for gene therapy in sickle cell disease
A systems pharmacology model for gene therapy in sickle cell disease Open
We developed a mathematical model for autologous stem cell therapy to cure sickle cell disease (SCD). Experimental therapies using this approach seek to engraft stem cells containing a curative gene. These stem cells are expected to produc…
View article: Mark William Pickett
Mark William Pickett Open
Mark William Pickett came to medicine relatively late in life, having initially completed a degree in microbiology at the University of Sheffield (1st class honours) and subsequently a PhD. It was here …
View article: Pharmacokinetics and pharmacodynamics of a recombinant fusion protein linking activated coagulation factor VII with human albumin (rVIIa-FP) in patients with congenital FVII deficiency
Pharmacokinetics and pharmacodynamics of a recombinant fusion protein linking activated coagulation factor VII with human albumin (rVIIa-FP) in patients with congenital FVII deficiency Open
Objectives: Recombinant fusion protein linking activated factor VIIa to human albumin (rVIIa-FP) is a therapeutic option designed to prevent and treat bleeding events in patients with congenital FVII deficiency with reduced infusion freque…
View article: Effects of Hormonal Changes Throughout the Menstrual Cycle on Joint Laxity in Females
Effects of Hormonal Changes Throughout the Menstrual Cycle on Joint Laxity in Females Open
The objective of this study was to examine the levels of estrogens, progesterone, LH, FSH, estradiol and testosterone and their relation to ACL laxity throughout the menstrual cycle. Subjects were tested at the onset of menses, the first d…
View article: Sustained high trough factor IX activity levels with continued use of rIX‐FP in adult and paediatric patients with haemophilia B
Sustained high trough factor IX activity levels with continued use of rIX‐FP in adult and paediatric patients with haemophilia B Open
Bleeding severity in haemophilia usually correlates with the levels of circulating clotting factor.1 Patients with mild (factor levels 6%-40% of normal activity) or moderate haemophilia (1%-5%) bleed infrequently, predominantly due to trau…
View article: In the Kitchen at White Oaks
In the Kitchen at White Oaks Open
First gentleman's part-history, part-recipe book serves up a celebration of the president's home and those who lived there.
View article: Revolutionary Time and the Avant-Garde
Revolutionary Time and the Avant-Garde Open
"Since the decidedly bleak beginning of the twenty-first century, art practice has become increasingly politicized. Yet, few sustained defenses of the avant-garde have been put forward. Revolutionary Time and the Avant-Garde is the first b…
View article: Landscape and the little man: Aalto, the institution and the individual
Landscape and the little man: Aalto, the institution and the individual Open
The architecture of Alvar Aalto had numerous formative interests, including an awareness of the forms and poetics of landscape, and a regard for the “little man,” the individual Finn living in a modernised industrialised welfare state. The…