Robert J. Christy
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View article: Thermal damage to the skin from 8.2 and 95 GHz microwave exposures in swine
Thermal damage to the skin from 8.2 and 95 GHz microwave exposures in swine Open
A study of burn thresholds from superficially penetrating radio-frequency (RF) energy at 8.2 and 95 GHz for swine skin was conducted. The study determined the thresholds for superficial, partial-thickness, and full-thickness burn severitie…
View article: Development of a Static Avascular and Dynamic Vascular Human Skin Equivalent Employing Collagen/Keratin Hydrogels
Development of a Static Avascular and Dynamic Vascular Human Skin Equivalent Employing Collagen/Keratin Hydrogels Open
One of the primary complications in generating physiologically representative skin tissue is the inability to integrate vasculature into the system, which has been shown to promote the proliferation of basal keratinocytes and consequent ke…
View article: Comparison of Intact Fish Skin Graft and Allograft as Temporary Coverage for Full-Thickness Burns: A Non-Inferiority Study
Comparison of Intact Fish Skin Graft and Allograft as Temporary Coverage for Full-Thickness Burns: A Non-Inferiority Study Open
The extent and depth of burn injury may mandate temporary use of cadaver skin (allograft) to protect the wound and allow the formation of granulation tissue while split-thickness skin grafts (STSGs) are serially harvested from the same don…
View article: Review of machine learning for optical imaging of burn wound severity assessment
Review of machine learning for optical imaging of burn wound severity assessment Open
The field would benefit from systematic analysis of the effects of different input data modalities, training/testing sets, and ML classifiers on the reported accuracy. Despite this current limitation, ML-based algorithms show significant p…
View article: Epidemiological Assessment of Bovine Foot and Mouth Disease in different Sized Herds and among Species and Breed in Tamil Nadu, India
Epidemiological Assessment of Bovine Foot and Mouth Disease in different Sized Herds and among Species and Breed in Tamil Nadu, India Open
The dairy industry encounters substantial challenges due to livestock diseases that pose a threat to farmers' livelihood, food security and economy. Among the bovine diseases, Foot and Mouth disease (FMD) is most contagious and economicall…
View article: Evaluation of Topical Off-the-Shelf Therapies to Reduce the Need to Evacuate Battlefield-Injured Warfighters
Evaluation of Topical Off-the-Shelf Therapies to Reduce the Need to Evacuate Battlefield-Injured Warfighters Open
Introduction Immediate evacuation of burn casualties can be challenging in austere environments, and it is predicted to be even more difficult in future multi-domain battlespaces against near-peer foes. Therefore, a need exists to treat bu…
View article: The Role of Vitamin E in Thermal Burn Injuries, Infection, and Sepsis: A Review
The Role of Vitamin E in Thermal Burn Injuries, Infection, and Sepsis: A Review Open
Thermal burn injuries are still a serious public health concern in the United States, due to the initial insult and resulting comorbidities. Burned patients are increasingly susceptible to colonization by endogenous and exogenous microorga…
View article: Evaluation of Topical Off-The-Shelf Therapies to Improve Prolonged Field Care of Burn-Injured Service Members
Evaluation of Topical Off-The-Shelf Therapies to Improve Prolonged Field Care of Burn-Injured Service Members Open
Introduction Burns are common injuries on the battlefield. Given austere environments, surgical debridement of injured service members is often not feasible in these settings. Delays in surgical debridement create a risk of infection and d…
View article: Advances in Immunomodulation and Immune Engineering Approaches to Improve Healing of Extremity Wounds
Advances in Immunomodulation and Immune Engineering Approaches to Improve Healing of Extremity Wounds Open
Delayed healing of traumatic wounds often stems from a dysregulated immune response initiated or exacerbated by existing comorbidities, multiple tissue injury or wound contamination. Over decades, approaches towards alleviating wound infla…
View article: Characterization of a Human Platelet Lysate-Loaded Keratin Hydrogel for Wound Healing Applications In Vitro
Characterization of a Human Platelet Lysate-Loaded Keratin Hydrogel for Wound Healing Applications In Vitro Open
One of the promising approaches to facilitate healing and regenerative capacity includes the application of growth-factor-loaded biomaterials. Human platelet lysate (hPL) derived from platelet-rich plasma through a freeze-thaw process has …
View article: 615 Evaluation of Topical Off-The-Shelf Therapies to Improve Burn Wound Healing During Prolonged Field Care
615 Evaluation of Topical Off-The-Shelf Therapies to Improve Burn Wound Healing During Prolonged Field Care Open
Introduction Burns are common injuries in the battlefield. Given austere environments, prolonged field care (PFC) is often necessary. Delays in surgical debridement create a risk of infection and deranged healing for burn patients. As such…
View article: 613 Evaluation of Non-Euphoric Phytocannabinoid Elixir 14 (NEPE-14) Application in Deep Partial-Thickness Burn Wounds
613 Evaluation of Non-Euphoric Phytocannabinoid Elixir 14 (NEPE-14) Application in Deep Partial-Thickness Burn Wounds Open
Introduction Combat-related burn wounds can be caused by exposure to a wide variety of agents including heat, electricity, radiation, chemicals, and friction. Early intervention can decrease injury severity by preventing excess inflammatio…
View article: Cerium(III) Nitrate Containing Electrospun Wound Dressing for Mitigating Burn Severity
Cerium(III) Nitrate Containing Electrospun Wound Dressing for Mitigating Burn Severity Open
Thermal injuries pose a risk for service members in prolonged field care (PFC) situations or to civilians in levels of lower care. Without access to prompt surgical intervention and treatment, potentially salvageable tissues are compromise…
View article: Assessing multimodal optical imaging of perfusion in burn wounds
Assessing multimodal optical imaging of perfusion in burn wounds Open
View article: Evaluation of <scp>KP</scp>‐1199: a novel acetaminophen analog for hemostatic function and antinociceptive effects
Evaluation of <span>KP</span>‐1199: a novel acetaminophen analog for hemostatic function and antinociceptive effects Open
Background Acetaminophen (APAP) is a widely self‐prescribed analgesic for mild to moderate pain, but overdose or repeat doses can lead to liver injury and death. Kalyra Pharmaceuticals has developed a novel APAP analog, KP‐1199, currently …
View article: An Electrospun Poly-Ethylene Oxide/Cerium (III) Nitrate Dressing for Delayed Debridement and Improved Wound Healing of Warfighter Contact Burns
An Electrospun Poly-Ethylene Oxide/Cerium (III) Nitrate Dressing for Delayed Debridement and Improved Wound Healing of Warfighter Contact Burns Open
Introduction: Thermal burns account for 5-10% of casualties sustained in present-day conflicts and are expected to be one of the most common wounds to occur in future conflicts. Timely debridement of necrotic burn tissue can greatly reduce…
View article: Minimal Effects of Intravenous Administration of Xenogeneic Adipose Derived Stem Cells on Organ Function in a Porcine 40% TBSA Burn Model
Minimal Effects of Intravenous Administration of Xenogeneic Adipose Derived Stem Cells on Organ Function in a Porcine 40% TBSA Burn Model Open
Adipose stem cells (ASCs) have shown therapeutic promise for various conditions, including burn injury. While ASCs have immunomodulatory properties, concerns exist over pro-coagulant activity after intravenous (IV) administration. In the p…
View article: ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging
ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging Open
Background Patients with severe burn injury (over 20% of the total body surface area) experience profound hypermetabolism which significantly prolongs wound healing. Adipose-derived stem cells (ASCs) have been proposed as an attractive sol…
View article: Accelerated Wound Closure of Deep Partial Thickness Burns with Acellular Fish Skin Graft
Accelerated Wound Closure of Deep Partial Thickness Burns with Acellular Fish Skin Graft Open
Thermal injuries are caused by exposure to a variety of sources, and split thickness skin grafts are the gold standard treatment for severe burns; however, they may be impossible when there is no donor skin available. Large total body surf…
View article: Review of the Terminology Describing Ionizing Radiation-Induced Skin Injury: A Case for Standardization
Review of the Terminology Describing Ionizing Radiation-Induced Skin Injury: A Case for Standardization Open
Ionizing radiation causes injury to the skin that produces a complex clinical presentation that is managed by various paradigms without clear standards. The situation is further complicated by the fact that clinicians and researchers often…
View article: Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels
Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels Open
Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the…
View article: Enzymatic Debridement of Porcine Burn Wounds via a Novel Protease, SN514
Enzymatic Debridement of Porcine Burn Wounds via a Novel Protease, SN514 Open
Necrotic tissue generated by a thermal injury is typically removed via surgical debridement. However, this procedure is commonly associated with blood loss and the removal of viable healthy tissue. For some patients and contexts such as ex…
View article: Maintaining a stable environment for electron microscopy
Maintaining a stable environment for electron microscopy Open
As new technologies continue to come to market, laboratories are expanding and investing in more and more electronic equipment.Every inch of the laboratory must be put to good use as space becomes ever-more precious.This busy setting, comb…
View article: Spatial Frequency Domain Imaging (SFDI) of clinical burns: A case report
Spatial Frequency Domain Imaging (SFDI) of clinical burns: A case report Open
While visual assessment by a clinician is the standard of care for burn severity evaluations, new technologies at various stages of development are attempting to add objectivity to this practice by quantifying burn severity. Assessment acc…
View article: Standards in Biologic Lesions: Cutaneous Thermal Injury and Inhalation Injury Working Group 2018 Meeting Proceedings
Standards in Biologic Lesions: Cutaneous Thermal Injury and Inhalation Injury Working Group 2018 Meeting Proceedings Open
On August 27 and 28, 2018, the American Burn Association, in conjunction with Underwriters Laboratories, convened a group of experts on burn and inhalation injury in Washington, DC. The goal of the meeting was to identify and discuss the e…
View article: <i>In Vivo</i> Evaluation of Three-Dimensional Printed, Keratin-Based Hydrogels in a Porcine Thermal Burn Model
<i>In Vivo</i> Evaluation of Three-Dimensional Printed, Keratin-Based Hydrogels in a Porcine Thermal Burn Model Open
Keratin is a natural material that can be derived from the cortex of human hair. Our group had previously presented a method for the printed, sequential production of three-dimensional (3D) keratin scaffolds. Using a riboflavin-sodium pers…
View article: Spatial frequency domain imaging: a quantitative, noninvasive tool for in vivo monitoring of burn wound and skin graft healing
Spatial frequency domain imaging: a quantitative, noninvasive tool for in vivo monitoring of burn wound and skin graft healing Open
There is a need for noninvasive, quantitative methods to characterize wound healing in the context of longitudinal investigations related to regenerative medicine. Such tools have the potential to inform the assessment of wound status and …
View article: Delivery of silver sulfadiazine and adipose derived stem cells using fibrin hydrogel improves infected burn wound regeneration
Delivery of silver sulfadiazine and adipose derived stem cells using fibrin hydrogel improves infected burn wound regeneration Open
Infection control is necessary for improved burn wound regeneration. In this study contact burn wounds were induced on the dorsum of the rats and were infected with Pseudomonas aeruginosa (107cfu/ml of saline) and left overnight (12-14 hou…
View article: Burn wound classification model using spatial frequency-domain imaging and machine learning
Burn wound classification model using spatial frequency-domain imaging and machine learning Open
Accurate assessment of burn severity is critical for wound care and the course of treatment. Delays in classification translate to delays in burn management, increasing the risk of scarring and infection. To this end, numerous imaging tech…
View article: Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain
Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain Open