John Conto
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View article: Pre-transplant Screening for MMP-9 in Allogeneic HSCT Candidates
Pre-transplant Screening for MMP-9 in Allogeneic HSCT Candidates Open
Purpose: InflammaDry® (Quidel Eye Health, San Diego, California), an FDA-approved point-of-care commercial test, measures matrix metalloproteinase-9 (MMP-9) levels in the tear film. MMP-9 is an inflammatory biomarker that is elevated in re…
View article: LipiFlow for the treatment of dry eye disease
LipiFlow for the treatment of dry eye disease Open
LipiFlow performs similarly to other commonly used DED treatments with regard to DED signs and symptoms. The best available evidence was deemed to have a high level of bias, leading to low or very low certainty evidence. Additional researc…
View article: Use of InflammaDry® for MMP-9 detection in ocular graft versus host disease
Use of InflammaDry® for MMP-9 detection in ocular graft versus host disease Open
Background: InflammaDry® is a point-of-care test that can detect matrix metalloproteinase-9 (MMP-9), an inflammatory biomarker that is elevated in ocular surface stress and desiccation, such as in ocular graft-versus-host disease (oGVHD). …
View article: LipiFlow for the treatment of dry eye disease
LipiFlow for the treatment of dry eye disease Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the effectiveness of the LipiFlow Thermal Pulsation System on dry eye signs and symptoms compared to placebo or other commercially availabl…
View article: Chronic Ocular Graft Versus Host Disease: An Update and Review
Chronic Ocular Graft Versus Host Disease: An Update and Review Open
An updated comprehensive literature review was completed of chronic ocular graft versus host disease (oGVHD) to identify current and future considerations as to the causes, diagnosis, and treatment of this complication after allogenic hema…
View article: A Review of Limbal Stem Cell Deficiency
A Review of Limbal Stem Cell Deficiency Open
Limbal stem cell deficiency (LSCD) can be secondary to multiple etiologies including contact lens wear, chemical or thermal trauma, and systemic disease, any of which can result in the reduction of the number of stem cells or their decreas…