John D. Minna
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View article: Figure S7 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma
Figure S7 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma Open
Comparing NE score-associated features between SCLC and other cancer types.
View article: Figure S1 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma
Figure S1 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma Open
Intratumoral NE heterogeneity in SCLC patient tumors and intra-cell line NE heterogeneity in SCLC and NBL cell lines.
View article: Figure S4 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma
Figure S4 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma Open
SCLC vs. NBL concordance of NE score association with omics, drug sensitivity, and dependency data.
View article: Figure S2 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma
Figure S2 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma Open
Known NBL prognostic factors consistently associate with outcome across different NBL studies but not NE scores.
View article: TMPRSS11B promotes an acidified microenvironment and immune suppression in squamous lung cancer
TMPRSS11B promotes an acidified microenvironment and immune suppression in squamous lung cancer Open
Lung cancer is the leading cause of cancer-related deaths worldwide. Existing therapeutic options have limited efficacy, particularly for lung squamous cell carcinoma (LUSC), underscoring the critical need for the identification of new the…
View article: Supplementary Figure 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 3 shows the effect of ISR pathway activation on dendritic cells and T cells.
View article: Supplementary Table 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Table 2 shows the primers used in this study.
View article: Data from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Data from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
The integrated stress response (ISR) is an adaptive pathway hijacked by cancer cells to survive cellular stresses in the tumor microenvironment. ISR activation potently induces PD-L1, leading to suppression of antitumor immunity. In this s…
View article: Supplementary Table 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Table 4 shows the clinicopathological characteristics of surgically resected primary NSCLC patients included in this study.
View article: Supplementary Figure 6 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 6 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 6 shows the characterization of CD155 expression in surgically resected primary NSCLC patients.
View article: SARS-CoV-2 vaccine failure rates and predictors of immune response in a diverse immunocompromised patient population
SARS-CoV-2 vaccine failure rates and predictors of immune response in a diverse immunocompromised patient population Open
Supported by a grant from Regeneron Pharmaceuticals, Inc., and P54 CA260560.
View article: Supplementary Figure 5 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 5 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 5 shows the effect of ISR pathway inhibition on immune cell populations in vivo.
View article: Supplementary Figure 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 2 shows the effect of ISR pathway activation on protein and mRNA stability, and translation.
View article: Supplementary Table 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Table 1 shows the chemicals used in this study.
View article: Supplementary Figure 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 4 shows the effect of ISR pathway inhibition in vitro and in vivo.
View article: Supplementary Figure 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 1 shows the effect of ISR pathway activation on multiple immune checkpoint proteins
View article: Supplementary Table 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Table 3 shows the antibodies used in this study.
View article: Supplementary Figure S1 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma
Supplementary Figure S1 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma Open
Figure S1. Sorting of CD24highCD44lowEPCAMhigh tumor propagating cells.
View article: Supplementary Table S4 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma
Supplementary Table S4 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma Open
Table S4. Tumor formation in H209 in vivo ELDA.
View article: Supplementary Figure S3 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma
Supplementary Figure S3 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma Open
Figure S3. Inhibition of ERK phosphorylation does not affect TPC function.
View article: Supplementary Table S2 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma
Supplementary Table S2 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma Open
Table S2. KSR2 is preferentially expressed in human SCLC-A cell lines.
View article: Data from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma
Data from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma Open
Small cell lung carcinoma (SCLC) tumors are heterogeneous, with a subpopulation of cells primed for tumor initiation. In this study, we show that kinase suppressor of Ras 2 (KSR2) promotes the self-renewal and clonogenicity of SCLC cells. …
View article: Supplementary Figure S2 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma
Supplementary Figure S2 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma Open
Figure S2. Proliferation, apoptosis, and subtype are not affected by KSR2 disruption in H209 tumor xenografts.
View article: Supplementary Table S3 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma
Supplementary Table S3 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma Open
Table S3. Tumor formation in KP1 in vivo ELDA.
View article: Supplementary Table S1 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma
Supplementary Table S1 from KSR2 Promotes Self-Renewal and Clonogenicity of Small Cell Lung Carcinoma Open
Table S1. Key resources and reagents used in this study.
View article: Contrasting interferon-mediated antiviral responses in human lung adenocarcinoma cells
Contrasting interferon-mediated antiviral responses in human lung adenocarcinoma cells Open
Lung cancers develop from lung epithelial cells after a series of genetic and epigenetic changes, and these cells are major sites of influenza virus infection. Thus, we explored how changes found in patient-derived lung cancer cell lines i…
View article: The Current State of Tumor Microenvironment-Specific Therapies for Non-Small Cell Lung Cancer
The Current State of Tumor Microenvironment-Specific Therapies for Non-Small Cell Lung Cancer Open
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality. Exploration of the tumor microenvironment (TME) has resulted in dramatic advancements in the treatment of NSCLC through the advent of immunotherapy. …
View article: High KYNU Expression Is Associated with Poor Prognosis, KEAP1/STK11 Mutations, and Immunosuppressive Metabolism in Patient-Derived but Not Murine Lung Adenocarcinomas
High KYNU Expression Is Associated with Poor Prognosis, KEAP1/STK11 Mutations, and Immunosuppressive Metabolism in Patient-Derived but Not Murine Lung Adenocarcinomas Open
Background/Objectives: We aimed to discover genes with bimodal expression linked to patient outcomes, to reveal underlying oncogenotypes and identify new therapeutic insights in lung adenocarcinoma (LUAD). Methods: We performed meta-analys…
View article: Table S2 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Table S2 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Depositor communications, describing input from data depositors
View article: Table S1 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Table S1 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Current collection of LCAMGDB datasets