John D. Pickard YOU? Author Swipe

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Clinical Characteristics and Mortality of Neurocritical Care Patients With Post-traumatic Cerebral Venous Outflow Compromise Open

Tommi K. Korhonen, Moritz Steinruecke, David Clark, Ivan Timofeev, Adel Helmy , et al. · 2025

BACKGROUND AND OBJECTIVES: The clinical characteristics and natural history of post-traumatic cerebral venous outflow compromise (VOC) are poorly characterized. We aimed to determine the prevalence of VOC in at-risk traumatic brain injury …

Clinical indications and patient outcomes of intracranial venous sinus stenting beyond overt idiopathic intracranial hypertension: a scoping review Open

Shiva A. Nischal, Rocío Fernández‐Méndez, Vasu Gautam, Shaan Patel, Catherine McMahon , et al. · 2025

Background Intracranial venous sinus stenting (VSS) was initially developed as an alternative approach to addressing venous outflow obstruction in the context of idiopathic intracranial hypertension (IIH). In recent years, the technique ha…

Cognitive Motor Dissociation in Disorders of Consciousness Open

Yelena G. Bodien, Judith Allanson, Paolo Cardone, Arthur Bonhomme, Jerina Carmona , et al. · 2024

Approximately one in four participants without an observable response to commands performed a cognitive task on fMRI or EEG as compared with one in three participants with an observable response to commands. (Funded by the James S. McDonne…

A synergistic workspace for human consciousness revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2024

How is the information-processing architecture of the human brain organised, and how does its organisation support consciousness? Here, we combine network science and a rigorous information-theoretic notion of synergy to delineate a ‘syner…

Author response: A synergistic workspace for human consciousness revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2024

A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans Open

Dorottya Szocs, Dian Lyu, Andrea I. Luppi, Peter Coppola, Rebecca Woodrow , et al. · 2024

Summary Currently, there is substantial ongoing discussion around the functional role of the thalamus in consciousness. What is missing in the literature, however, is a systematic investigation of the relevance of specific thalamic nuclei …

Author response: A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2024

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing arc…

A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2024

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing arc…

A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2024

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing arc…

Author response: A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2024

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing arc…

Author Response: A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2024

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing arc…

Reviewer #2 (Public Review): A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2024

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing arc…

Reviewer #3 (Public Review): A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2024

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing arc…

A synergistic workspace for human consciousness revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2023

How is the information-processing architecture of the human brain organised, and how does its organisation support consciousness? Here, we combine network science and a rigorous information-theoretic notion of synergy to delineate a ‘syner…

A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2023

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing arc…

Author Response: A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2023

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing arc…

Reduced emergent character of neural dynamics in patients with a disrupted connectome Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2023

Distributed harmonic patterns of structure-function dependence orchestrate human consciousness Open

Andrea I. Luppi, Jakub Vohryzek, Morten L. Kringelbach, Pedro A. M. Mediano, Michael M Craig , et al. · 2023

A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations of consciousn…

The complexity of the stream of consciousness Open

Peter Coppola, Judith Allanson, Lorina Naçi, R. Adapa, Paola Finoia , et al. · 2022

Diffusion Tensor Imaging Profiles Can Distinguish Diffusivity and Neural Properties of White Matter Injury in Hydrocephalus vs. Non-hydrocephalus Using a Strategy of a Periodic Table of DTI Elements Open

Nicole C. Keong, Christine Lock, Shereen Xue Yun Soon, Aditya Tri Hernowo, Zofia Czosnyka , et al. · 2022

Background: The aim of this study was to create a simplistic taxonomy to improve transparency and consistency in, and reduce complexity of, interpreting diffusion tensor imaging (DTI) profiles in white matter disruption. Using a novel stra…

Reduced emergent character of neural dynamics in patients with a disrupted connectome Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2022

High-level brain functions are widely believed to emerge from the orchestrated activity of multiple neural systems. However, lacking a formal definition and practical quantification of emergence for experimental data, neuroscientists have …

Evaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months Open

Angelos G. Kolias, Hadie Adams, Ivan Timofeev, Elizabeth A. Corteen, Iftakher Hossain , et al. · 2022

ISRCTN Identifier: 66202560.

Prolonged disorders of consciousness: A response to a “critical evaluation of the new UK guidelines.” Open

Derick T Wade, Lynne Turner‐Stokes, E. Diane Playford, Judith Allanson, John D. Pickard · 2022

Background In 2020, The London Royal College of Physicians published “Prolonged disorders of consciousness following sudden-onset brain injury: national clinical guidelines”. In 2021, in the journal Brain, Scolding et al. published “a crit…

Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness Open

Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard , et al. · 2022

Network dynamics scale with levels of awareness Open

Peter Coppola, Lennart R. B. Spindler, Andrea I. Luppi, R. Adapa, Lorina Naçi , et al. · 2022

Small world topologies are thought to provide a valuable insight into human brain organisation and consciousness. However, functional magnetic resonance imaging studies in consciousness have not yielded consistent results. Given the import…

Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients Open

Mathew R. Guilfoyle, Adel Helmy, Joseph E. Donnelly, Matthew G. Stovell, Ivan Timofeev , et al. · 2021

Traumatic brain injury (TBI) is a major cause of death and disability, particularly amongst young people. Current intensive care management of TBI patients is targeted at maintaining normal brain physiology and preventing secondary injury.…

Equitable Access to State-of-the-Art Medical Technology—a Malaysian Mini–Public-Private Partnership Case Study Open

Vicknes Waran, R. Thillainathan, Ravindran Karuppiah, John D. Pickard · 2021

Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation Open

Lennart R. B. Spindler, Andrea I. Luppi, R. Adapa, Michael M Craig, Peter Coppola , et al. · 2021

Significance Understanding the neural bases of consciousness is of basic scientific and clinical importance. Human neuroimaging has established that a network of interconnected brain regions known as the default mode network disintegrates …

A paradigm for chronic fatigue syndrome: caught between idiopathic intracranial hypertension and spontaneous intracranial hypotension; caused by cranial venous outflow obstruction Open

Nicholas Higgins, John D. Pickard · 2021

In chronic fatigue syndrome a normal intracranial pressure does not exclude significant physiological disturbance.

Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury Open

Jeroen Hermanides, Young T. Hong, Monica Trivedi, Joanne Outtrim, Franklin I. Aigbirhio , et al. · 2021

Metabolic derangements following traumatic brain injury are poorly characterized. In this single-centre observational cohort study we combined 18F-FDG and multi-tracer oxygen-15 PET to comprehensively characterize the extent and spatial pa…

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