John Norrie
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View article: Morphine for chronic breathlessness (MABEL) in the UK: a health economic evaluation of a multisite, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial
Morphine for chronic breathlessness (MABEL) in the UK: a health economic evaluation of a multisite, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial Open
Objectives To compare costs and health consequences and to assess the cost-effectiveness of using low-dose oral long-acting morphine in people with chronic breathlessness. Design Within-trial planned cost-consequences and cost-effectivenes…
View article: Perioperative Medicine for Older People Undergoing Surgery Scale Up (POPS-SUp): study protocol
Perioperative Medicine for Older People Undergoing Surgery Scale Up (POPS-SUp): study protocol Open
Background Surgery provides definitive management of many age-related diseases, relieving symptoms or extending life. Age-related physiological decline, multimorbidity, and frailty predispose older people to postoperative complications and…
View article: Morphine for chronic breathlessness (MABEL) in the UK: a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial
Morphine for chronic breathlessness (MABEL) in the UK: a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial Open
NIHR Health Technology Assessment programme (HTA Project 17/34/01).
View article: Correction: Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank
Correction: Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank Open
[This corrects the article DOI: 10.1371/journal.pmed.1004532.].
View article: Four Year Clinical and Cost Effectiveness of Vaginal Pessary Self‐Management Versus Clinic‐Based Care for Pelvic Organ Prolapse (<scp>TOPSY</scp>): Long Term Follow‐Up of a Randomised Controlled Superiority Trial
Four Year Clinical and Cost Effectiveness of Vaginal Pessary Self‐Management Versus Clinic‐Based Care for Pelvic Organ Prolapse (<span>TOPSY</span>): Long Term Follow‐Up of a Randomised Controlled Superiority Trial Open
Objective To compare long‐term clinical and cost‐effectiveness of pessary self‐management (SM) with clinic‐based care (CBC) for pelvic floor‐specific quality of life (QoL). Design Four‐year questionnaire follow‐up of trial participants. Se…
View article: Robustly measuring multimorbidity using disparate linked datasets
Robustly measuring multimorbidity using disparate linked datasets Open
Background Measurement of multimorbidity, the co-occurrence of two or more conditions in the same individual, is highly variable which limits the consistency and reproducibility of research. Methods Using data from 172,563 UK Biobank (UKB)…
View article: Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report
Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report Open
Background Almost all large-scale trials of disease-modifying therapeutic agents in critical care have failed to show benefit for patients, which may be explained in part by the clinical and biological heterogeneity inherent in virtually a…
View article: A digital intervention to improve mental health and interpersonal resilience for young people who have experienced online sexual abuse: the i-Minds non-randomised feasibility clinical trial and nested qualitative study
A digital intervention to improve mental health and interpersonal resilience for young people who have experienced online sexual abuse: the i-Minds non-randomised feasibility clinical trial and nested qualitative study Open
Background No evidence-based support for young people who have experienced technology-assisted sexual abuse exists. The project’s aims were to develop a digital intervention that improves mentalisation (the ability to understand the minds …
View article: Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation
Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation Open
Background Overactive bladder is a common problem affecting the United Kingdom adult female population. Symptoms include urinary urgency, with or without urgency incontinence, increased daytime urinary frequency and nocturia. Initial conse…
View article: GRACE: protocol for a UK, secondary care, multicentre, assessor-blinded randomised controlled trial with a non-inferiority comparison to evaluate graduated compression stockings as an adjunct to extended duration pharmacological thromboprophylaxis for venous thromboembolism prevention
GRACE: protocol for a UK, secondary care, multicentre, assessor-blinded randomised controlled trial with a non-inferiority comparison to evaluate graduated compression stockings as an adjunct to extended duration pharmacological thromboprophylaxis for venous thromboembolism prevention Open
Introduction Venous thromboembolism (VTE) occurs when a blood clot forms in a vein. It is comprised of deep vein thrombosis (DVT) and pulmonary embolism and can be potentially life-threatening. Patients undergoing surgery are at increased …
View article: Open science policy guidelines promoting open data sharing in low and middle-income countries for respiratory health research under NIHR Global RESPIRE project
Open science policy guidelines promoting open data sharing in low and middle-income countries for respiratory health research under NIHR Global RESPIRE project Open
Open science drives progress, especially in the low-and-middle-income countries (LMICs), where data security and confidentiality are at risk due to lack of resources and non-compliance with diverse privacy laws. The National Institutes of …
View article: A digital intervention to improve mental health and interpersonal resilience in young people who have experienced Technology-Assisted Sexual Abuse: a feasibility clinical trial
A digital intervention to improve mental health and interpersonal resilience in young people who have experienced Technology-Assisted Sexual Abuse: a feasibility clinical trial Open
Background A digital mental health intervention (DMHI) to improve mentalisation in young people who have experienced technology-assisted sexual abuse (TASA) may reduce the risk of re-victimisation and future harm and make them more resilie…
View article: Compression Hosiery to Avoid the Post-Thrombotic Syndrome: a synopsis of the CHAPS RCT
Compression Hosiery to Avoid the Post-Thrombotic Syndrome: a synopsis of the CHAPS RCT Open
Background Approximately half of adults diagnosed with deep vein thrombosis will develop the post-thrombotic syndrome leading to chronic symptoms – including leg pain, oedema, venous ectasia and, in 5% of cases, venous ulceration. Risk fac…
View article: Health Economic Evaluation of a Double-Blind, Randomised, Placebo-Controlled Trial of Low-Dose Oral Morphine (MABEL)
Health Economic Evaluation of a Double-Blind, Randomised, Placebo-Controlled Trial of Low-Dose Oral Morphine (MABEL) Open
Objectives To compare costs and health consequences and to assess the cost-effectiveness of using low-dose oral long-acting morphine in people with chronic breathlessness. Design Within-trial planned cost-consequences and cost-effectivenes…
View article: Cost-Effectiveness of α<sub>2</sub> Agonists for Intravenous Sedation in Patients With Critical Illness
Cost-Effectiveness of α<sub>2</sub> Agonists for Intravenous Sedation in Patients With Critical Illness Open
Importance Propofol and the α 2 agonists dexmedetomidine and clonidine are used for sedation in patients with critical illness receiving mechanical ventilation. Evidence about the cost-effectiveness of intravenous (IV) sedation with these …
View article: Optimising participation in a pulmonary rehabilitation programme for people living with chronic respiratory diseases in rural India: a feasibility study
Optimising participation in a pulmonary rehabilitation programme for people living with chronic respiratory diseases in rural India: a feasibility study Open
The study was registered at the Clinical Trials Registry - India (CTRI/2020/09/027818).
View article: Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT
Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT Open
Background Observational studies of people with chronic obstructive pulmonary disease using beta-blockers for cardiovascular disease indicate that beta-blocker use is associated with reduced risk of chronic obstructive pulmonary disease ex…
View article: Patient and healthcare professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: qualitative study of the CATHETER II trial
Patient and healthcare professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: qualitative study of the CATHETER II trial Open
Objectives To explore trial participants’ experience of long-term catheters (LTC), the acceptability of washout policies, their experience of the CATHETER II trial (a randomised controlled trial comparing the clinical effectiveness of vari…
View article: Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: a multicentre, superiority, parallel, open-label, randomised controlled trial
Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: a multicentre, superiority, parallel, open-label, randomised controlled trial Open
UK National Institute for Health and Care Research Health Technology Assessment Programme.
View article: A pilot study of a ketogenic diet in bipolar disorder: clinical, metabolic and magnetic resonance spectroscopy findings
A pilot study of a ketogenic diet in bipolar disorder: clinical, metabolic and magnetic resonance spectroscopy findings Open
Background Preliminary evidence suggests that a ketogenic diet may be effective for bipolar disorder. Aims To assess the impact of a ketogenic diet in bipolar disorder on clinical, metabolic and magnetic resonance spectroscopy outcomes. Me…
View article: Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank
Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank Open
Background Depression is associated with a range of adverse physical health outcomes. We aimed to quantify the association between depression and the subsequent rate of accrual of long-term physical health conditions in middle and older ag…
View article: mHealth intervention (mTB-Tobacco) for smoking cessation in people with drug-sensitive pulmonary tuberculosis in Bangladesh and Pakistan: protocol for an adaptive design, cluster randomised controlled trial (Quit4TB)
mHealth intervention (mTB-Tobacco) for smoking cessation in people with drug-sensitive pulmonary tuberculosis in Bangladesh and Pakistan: protocol for an adaptive design, cluster randomised controlled trial (Quit4TB) Open
Introduction People with tuberculosis (TB) who continue to smoke are more likely to have poor health outcomes than those who quit. Established smoking cessation approaches such as mHealth may help patients with TB quit smoking. This paper …
View article: Decellularized dermis allograft for the treatment of venous leg ulceration: the DAVE RCT
Decellularized dermis allograft for the treatment of venous leg ulceration: the DAVE RCT Open
Background Venous leg ulcers (VLUs) cause significant impairment to patients’ quality of life (QoL) and up to 30% do not heal at 6 months. Decellularized dermis (DCD) allografts have been shown to be effective in improving healing rates of…
View article: Intravenous lidocaine for gut function recovery in colonic surgery: a health economic evaluation of the ALLEGRO randomised clinical trial
Intravenous lidocaine for gut function recovery in colonic surgery: a health economic evaluation of the ALLEGRO randomised clinical trial Open
Objectives To compare costs, health outcomes and cost-effectiveness of using intravenous lidocaine (bolus given at induction of anaesthesia, followed by infusion for 6–12 hours) during colorectal surgery to improve the return of gastrointe…
View article: Women and birth partners’ experiences of cervical ripening at home and in hospital
Women and birth partners’ experiences of cervical ripening at home and in hospital Open
Background In the United Kingdom, induction of labour rates are rapidly rising, and around a third of pregnant women undergo the procedure. The first stage, cervical ripening, traditionally carried out in hospital, is increasingly offered …
View article: Hypertonic saline nasal irrigation and gargling for suspected or confirmed COVID-19: Pragmatic randomised controlled trial (ELVIS COVID-19)
Hypertonic saline nasal irrigation and gargling for suspected or confirmed COVID-19: Pragmatic randomised controlled trial (ELVIS COVID-19) Open
ClinicalTrials.gov (NCT05104372).
View article: A mHealth intervention (mTB-Tobacco) for smoking cessation in people with drug-sensitive pulmonary tuberculosis: protocol for an adaptive design, cluster randomised controlled trial (Quit4TB)
A mHealth intervention (mTB-Tobacco) for smoking cessation in people with drug-sensitive pulmonary tuberculosis: protocol for an adaptive design, cluster randomised controlled trial (Quit4TB) Open
Introduction People with tuberculosis (TB) who continue to smoke are more likely to have poor health outcomes than those who quit. Established smoking cessation approaches such as mHealth may help TB patients quit smoking. This paper summa…
View article: Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT
Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT Open
Background Problems in children’s early social and emotional development are likely to have major long-term consequences for the individual and society: maternal emotional well-being is associated with better outcomes. Interventions design…