John Danias
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View article: Proteomic Characterization of the Rhesus Macaque Lens Nucleus: Similarity to Human Lens, Age Effects on Protein Solubility, and Trends in Post-Translational Modifications
Proteomic Characterization of the Rhesus Macaque Lens Nucleus: Similarity to Human Lens, Age Effects on Protein Solubility, and Trends in Post-Translational Modifications Open
These data indicate a high level of conformity between rhesus macaque and human lens proteomes, and a few key differences. We identified several age-related differences in protein solubility and PTM that may contribute to lens pathology.
View article: The ocular surface microbiome of rhesus macaques
The ocular surface microbiome of rhesus macaques Open
Background The ocular surface microbiota (OSM) is important for eye health, and variations in OSM composition have been associated with multiple diseases in humans. Studies of OSM-disease dynamics in humans are confounded by lifestyle fact…
View article: Lamina Cribrosa Microstructure in Nonhuman Primates With Naturally Occurring Peripapillary Retinal Nerve Fiber Layer Thinning
Lamina Cribrosa Microstructure in Nonhuman Primates With Naturally Occurring Peripapillary Retinal Nerve Fiber Layer Thinning Open
Our findings indicate structural alterations in the LC of NHP exhibiting natural thinning of the RNFL, a common characteristic of glaucomatous damage.
View article: Effect of Glucosamine on Intraocular Pressure and Risk of Developing Glaucoma
Effect of Glucosamine on Intraocular Pressure and Risk of Developing Glaucoma Open
Précis: Glucosamine supplementation is common but can be associated with increased intraocular pressure (IOP) and could contribute to the pathogenesis of glaucoma. It may be prudent for ophthalmologists to elicit any history of glucosamine…
View article: Retinal thickness and antidepressants
Retinal thickness and antidepressants Open
Background Depression is associated with synaptic pruning in the brain. Antidepressants reverse this process. Synaptic pruning can be inferred by measuring retinal thickness with ocular coherence tomography (OCT). With data from UK Biobank…
View article: Recreating the Trabecular Outflow Tissue on Implantable, Micropatterned, Ultrathin, Porous Polycaprolactone Scaffolds
Recreating the Trabecular Outflow Tissue on Implantable, Micropatterned, Ultrathin, Porous Polycaprolactone Scaffolds Open
Glaucoma, where increased intraocular pressure (IOP) leads to damage to the optic nerve and loss of sight, is amongst the foremost causes of irreversible blindness worldwide. In primary open angle glaucoma, the increased IOP is a result of…
View article: Age-Related Differences in Ocular Features of a Naturalistic Free-Ranging Population of Rhesus Macaques
Age-Related Differences in Ocular Features of a Naturalistic Free-Ranging Population of Rhesus Macaques Open
Rhesus macaques exhibit age-related ocular associations similar to those observed in human aging, including decreased corneal thickness, increased axial length, myopic shift, and higher prevalence of cataract and retinal drusen.
View article: Age-related differences in ocular features of a naturalistic free-ranging population of rhesus macaques
Age-related differences in ocular features of a naturalistic free-ranging population of rhesus macaques Open
Purpose Rhesus macaques ( Macaca mulatta ) are the premier nonhuman primate model for studying human health and disease. We aimed to investigate if age was associated with ocular features of clinical relevance in a large cohort of free-ran…
View article: Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms Open
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mo…
View article: Tissue plasminogen activator rescues steroid-induced outflow facility reduction via non-enzymatic action.
Tissue plasminogen activator rescues steroid-induced outflow facility reduction via non-enzymatic action. Open
tPA enzymatic activity is not necessary in the regulation of aqueous humor outflow. tPA can increase the expression of matrix metalloproteinases in a cytokine-mediated fashion. This cascade of events may eventually lead to extracellular ma…
View article: Tissue Plasminogen Activator in Trabecular Meshwork Attenuates Steroid Induced Outflow Resistance in Mice
Tissue Plasminogen Activator in Trabecular Meshwork Attenuates Steroid Induced Outflow Resistance in Mice Open
Tissue plasminogen activator, a serine protease encoded by the PLAT gene is present in the trabecular meshwork (TM) and other ocular tissues and has been reported to be downregulated by treatment with steroids in vitro. Steroids are known …
View article: A Biomimetic, Stem Cell‐Derived In Vitro Ocular Outflow Model
A Biomimetic, Stem Cell‐Derived In Vitro Ocular Outflow Model Open
Age‐related human trabecular meshwork (HTM) cell loss is suggested to affect its ability to regulate aqueous humor outflow in the eye. In addition, disease‐related HTM cell loss is suggested to lead to elevated intraocular pressure in glau…
View article: Do epigenetic changes caused by commensal microbiota contribute to development of ocular disease? A review of evidence
Do epigenetic changes caused by commensal microbiota contribute to development of ocular disease? A review of evidence Open
There is evidence that genetic polymorphisms and environmentally induced epigenetic changes play an important role in modifying disease risk. The commensal microbiota has the ability to affect the cellular environment throughout the body w…
View article: Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation
Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation Open
tPA deficiency reduced outflow facility in mice and was associated with reduced MMP expression. The mechanism of action of tPA is unlikely to involve plasminogen activation. tPA is not the only mediator of TA-induced outflow facility chang…
View article: TGFβ2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor
TGFβ2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor Open
Members of the transforming growth factor beta (TGFβ) cytokine family have long been associated with affecting several cellular functions, including cell proliferation, differentiation and extracellular matrix (ECM) turnover. Of particular…
View article: A Pilot Study to Evaluate the Oral Microbiome and Dental Health in Primary Open-Angle Glaucoma
A Pilot Study to Evaluate the Oral Microbiome and Dental Health in Primary Open-Angle Glaucoma Open
Purpose: To evaluate possible associations between primary open-angle glaucoma (POAG), dental health, and the oral microbiome. Methods: Case-control study was conducted at SUNY Downstate. Adult subjects (40 to 87 y) were recruited as POAG …