John W. Devlin
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View article: 1171 Enhancing affinity of the novel HER2-targeting IgE, EPS 232, elicits superior anti-tumour activity supporting use in cancers with ultra-low HER2 expression
1171 Enhancing affinity of the novel HER2-targeting IgE, EPS 232, elicits superior anti-tumour activity supporting use in cancers with ultra-low HER2 expression Open
View article: Prediction of pharmacist medication interventions using medication regimen complexity
Prediction of pharmacist medication interventions using medication regimen complexity Open
Background Critically ill patients are managed with complex medication regimens that require medication management to optimize safety and efficacy. When performed by a critical care pharmacist (CCP), discrete medication management activiti…
View article: Augmenting Mortality Prediction in Critically Ill Adults With Medication Data and Machine Learning Models
Augmenting Mortality Prediction in Critically Ill Adults With Medication Data and Machine Learning Models Open
BACKGROUND: Mortality prediction in ICU adults is only marginally improved when medication regimen complexity (MRC) data is incorporated into traditional regression models. Machine learning (ML) may improve this prediction. OBJECTIVE: To c…
View article: Should delirium be routinely treated with haloperidol? Yes!
Should delirium be routinely treated with haloperidol? Yes! Open
View article: Impact of adding an airway safety prompt to the A–F bundle on unplanned extubation in the intensive care unit
Impact of adding an airway safety prompt to the A–F bundle on unplanned extubation in the intensive care unit Open
Objective Endotracheal intubation is a life-saving intervention for adults with acute respiratory failure (ARF) but may result in unplanned extubation (UE). The success of UE prevention efforts has varied. We describe the development, impl…
View article: Hybrid IgE-IgG1 antibodies (IgEG): a new antibody class that combines IgE and IgG functionality
Hybrid IgE-IgG1 antibodies (IgEG): a new antibody class that combines IgE and IgG functionality Open
IgG-based anti-cancer therapies have achieved promising clinical outcomes, but, especially for patients with solid tumors, response rates vary. IgE antibodies promote distinct immune responses compared to IgG and have shown anti-tumoral pr…
View article: Airway Safety During Mechanical Ventilation: Survey of ICU Clinicians Practices and Perceptions
Airway Safety During Mechanical Ventilation: Survey of ICU Clinicians Practices and Perceptions Open
We report results from a survey of members of the Society of Critical Care Medicine to assess ICU clinicians’ perceptions of artificial airway safety practices and unplanned extubation (UE) prevention. The survey was distributed between Ja…
View article: Comparing the impact of targeting limited driving pressure to low tidal volume ventilation on mortality in mechanically ventilated adults with COVID-19 ARDS: an exploratory target trial emulation
Comparing the impact of targeting limited driving pressure to low tidal volume ventilation on mortality in mechanically ventilated adults with COVID-19 ARDS: an exploratory target trial emulation Open
Background An association between driving pressure (∆P) and the outcomes of invasive mechanical ventilation (IMV) may exist. However, the effect of a sustained limitation of ∆P on mortality in patients with acute respiratory distress syndr…
View article: INhaled Sedation versus Propofol in REspiratory failure in the Intensive Care Unit (INSPiRE-ICU1): protocol for a randomised, controlled trial
INhaled Sedation versus Propofol in REspiratory failure in the Intensive Care Unit (INSPiRE-ICU1): protocol for a randomised, controlled trial Open
Introduction Sedation in mechanically ventilated adults in the intensive care unit (ICU) is commonly achieved with intravenous infusions of propofol, dexmedetomidine or benzodiazepines. Significant limitations associated with each can impa…
View article: Endoscopic Retrograde Cholangio-Pancreatography and Endoscopic Ultrasound in the Management of Paediatric Acute Recurrent Pancreatitis and Chronic Pancreatitis
Endoscopic Retrograde Cholangio-Pancreatography and Endoscopic Ultrasound in the Management of Paediatric Acute Recurrent Pancreatitis and Chronic Pancreatitis Open
Objectives: To evaluate the role of ERCP (endoscopic retrograde cholangio-pancreatography) and EUS (endoscopic ultrasound) and to describe the efficacy and safety of these procedures in a paediatric cohort with chronic pancreatitis (CP) an…
View article: Cognitive and functional change in skilled nursing facilities: Differences by delirium and Alzheimer's disease and related dementias
Cognitive and functional change in skilled nursing facilities: Differences by delirium and Alzheimer's disease and related dementias Open
Background Whether cognitive and functional recovery in skilled nursing facilities (SNF) following hospitalization differs by delirium and Alzheimer's disease related dementias (ADRD) has not been examined. Objective To compare change in c…
View article: Augmenting mortality prediction with medication data and machine learning models
Augmenting mortality prediction with medication data and machine learning models Open
Background In critically ill patients, complex relationships exist among patient disease factors, medication management, and mortality. Considering the potential for nonlinear relationships and the high dimensionality of medication data, m…
View article: A common data model for the standardization of intensive care unit medication features
A common data model for the standardization of intensive care unit medication features Open
Objective Common data models provide a standard means of describing data for artificial intelligence (AI) applications, but this process has never been undertaken for medications used in the intensive care unit (ICU). We sought to develop …
View article: Unsupervised machine learning analysis to identify patterns of ICU medication use for fluid overload prediction
Unsupervised machine learning analysis to identify patterns of ICU medication use for fluid overload prediction Open
INTRODUCTION Intravenous (IV) medications are a fundamental cause of fluid overload (FO) in the intensive care unit (ICU); however, the association between IV medication use (including volume), administration timing, and FO occurrence rema…
View article: Catalyzing delirium research: The <scp>NIDUS</scp> delirium network
Catalyzing delirium research: The <span>NIDUS</span> delirium network Open
Delirium, an acute disorder of attention and cognition, has been well-recognized as a common, serious, and potentially preventable contributor to poor outcomes in older adults, including substantial morbidity, mortality, and loss of indepe…
View article: How does haloperidol influence the long-term outcomes of delirium?
How does haloperidol influence the long-term outcomes of delirium? Open
View article: The Delphi Delirium Management Algorithms. A practical tool for clinicians, the result of a modified Delphi expert consensus approach.
The Delphi Delirium Management Algorithms. A practical tool for clinicians, the result of a modified Delphi expert consensus approach. Open
Delirium is common in hospitalised patients, and there is currently no specific treatment. Identifying and treating underlying somatic causes of delirium is the first priority once delirium is diagnosed. Several international guidelines pr…
View article: Clinical Impact of the Implementation Strategies Used to Apply the 2013 Pain, Agitation/Sedation, Delirium or 2018 Pain, Agitation/Sedation, Delirium, Immobility, Sleep Disruption Guideline Recommendations: A Systematic Review and Meta-Analysis
Clinical Impact of the Implementation Strategies Used to Apply the 2013 Pain, Agitation/Sedation, Delirium or 2018 Pain, Agitation/Sedation, Delirium, Immobility, Sleep Disruption Guideline Recommendations: A Systematic Review and Meta-Analysis Open
OBJECTIVES: To summarize the effectiveness of implementation strategies for ICU execution of recommendations from the 2013 Pain, Agitation/Sedation, Delirium (PAD) or 2018 PAD, Immobility, Sleep Disruption (PADIS) guidelines. DATA SOURCES:…
View article: Relationship Between Pain and Delirium in Critically Ill Adults
Relationship Between Pain and Delirium in Critically Ill Adults Open
OBJECTIVES: Although opioids are frequently used to treat pain, and are an important risk for ICU delirium, the association between ICU pain itself and delirium remains unclear. We sought to evaluate the relationship between ICU pain and d…
View article: Machine learning vs. traditional regression analysis for fluid overload prediction in the ICU
Machine learning vs. traditional regression analysis for fluid overload prediction in the ICU Open
View article: Scheduled intravenous opioids
Scheduled intravenous opioids Open
View article: Data Missingness Reporting and Use of Methods to Address It in Critical Care Cohort Studies
Data Missingness Reporting and Use of Methods to Address It in Critical Care Cohort Studies Open
IMPORTANCE: Failure to recognize and address data missingness in cohort studies may lead to biased results. Although Strengthening the Reporting of Observational Studies in Epidemiology reporting guidelines advocate data missingness report…
View article: Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial
Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial Open
View article: Frequency of screening and SBT Technique Trial—North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan
Frequency of screening and SBT Technique Trial—North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan Open
View article: A Common Data Model for the standardization of intensive care unit (ICU) medication features in artificial intelligence (AI) applications
A Common Data Model for the standardization of intensive care unit (ICU) medication features in artificial intelligence (AI) applications Open
Objective Common Data Models provide a standard means of describing data for artificial intelligence (AI) applications, but this process has never been undertaken for medications used in the intensive care unit (ICU). We sought to develop …
View article: Evaluation of medication regimen complexity as a predictor for mortality
Evaluation of medication regimen complexity as a predictor for mortality Open
View article: Machine learning vs. traditional regression analysis for fluid overload prediction in the ICU
Machine learning vs. traditional regression analysis for fluid overload prediction in the ICU Open
Background Fluid overload, while common in the ICU and associated with serious sequelae, is hard to predict and may be influenced by ICU medication use. Machine learning (ML) approaches may offer advantages over traditional regression tech…
View article: Pharmacophenotype identification of intensive care unit medications using unsupervised cluster analysis of the ICURx common data model
Pharmacophenotype identification of intensive care unit medications using unsupervised cluster analysis of the ICURx common data model Open
Background Identifying patterns within ICU medication regimens may help artificial intelligence algorithms to better predict patient outcomes; however, machine learning methods incorporating medications require further development, includi…
View article: Measures for the Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS)
Measures for the Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS) Open
OBJECTIVES: To gain consensus on measurement methods for outcomes (delirium occurrence, severity, time to resolution, mortality, health-related quality of life [HrQoL], emotional distress including anxiety, depression, acute stress, and po…
View article: Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement
Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement Open
Background: Sleep and circadian disruption (SCD) is common and severe in the ICU. On the basis of rigorous evidence in non-ICU populations and emerging evidence in ICU populations, SCD is likely to have a profound negative impact on…