John E. Baker
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View article: Radiation-Induced Cardiotoxicity in Hypertensive Salt-Sensitive Rats: A Feasibility Study
Radiation-Induced Cardiotoxicity in Hypertensive Salt-Sensitive Rats: A Feasibility Study Open
Radiation therapy (RT) plays a vital role in managing thoracic cancers, though it can lead to adverse effects, including significant cardiotoxicity. Understanding the risk factors like hypertension in RT is important for patient prognosis …
View article: Advancing cell-free DNA as a biomarker of damage to heart caused by ionizing radiation
Advancing cell-free DNA as a biomarker of damage to heart caused by ionizing radiation Open
Exposure to diagnostic and therapeutic radiation introduces risks for development of diseases later in life by causing DNA damage in cells. Currently, there is no clinical method for determining exposure risk caused by radiation toxicity t…
View article: Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand
Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand Open
Introduction To evaluate the long-term risk of developing type 2 diabetes (T2D) among women with a history of gestational diabetes mellitus (GDM) compared with those with impaired glucose tolerance (IGT). Research design and methods Using …
View article: Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats
Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats Open
Introduction Effects and interactions between different spaceflight stressors are expected to be experienced by crew on missions when exposed to microgravity and galactic cosmic rays (GCRs). One of the limitations of previous studies on si…
View article: Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats
Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats Open
Introduction: The space environment astronauts experience during space missions consists of multiple environmental challenges, including microgravity. In this study, we assessed the behavioral and cognitive performances of male Fisher rats…
View article: Improving attitudes towards adders (<i>Vipera berus</i>) and nature connectedness in primary‐age group children
Improving attitudes towards adders (<i>Vipera berus</i>) and nature connectedness in primary‐age group children Open
Adder ( Vipera berus ) populations are experiencing declines in many countries, including the United Kingdom. Perceptions of adders and other venomous snakes are generally negative, making conservation of these species a challenge, and per…
View article: Association Between Onset of Type 2 Diabetes and Risk of Atrial Fibrillation in New Zealanders With Impaired Glucose Tolerance Over 25 Years
Association Between Onset of Type 2 Diabetes and Risk of Atrial Fibrillation in New Zealanders With Impaired Glucose Tolerance Over 25 Years Open
Background The association between the onset of type 2 diabetes (T2D) and atrial fibrillation (AF) risk in individuals with impaired glucose tolerance (IGT) remains unclear. This study aimed to investigate the relationship between the inci…
View article: Exposure to multiple ion beams, broadly representative of galactic cosmic rays, causes perivascular cardiac fibrosis in mature male rats
Exposure to multiple ion beams, broadly representative of galactic cosmic rays, causes perivascular cardiac fibrosis in mature male rats Open
Long-duration space exploratory missions to the Earth’s moon and the planet Mars are actively being planned. Such missions will require humans to live for prolonged periods beyond low earth orbit where astronauts will be continuously expos…
View article: Correction: Lenarczyk et al. T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys. Toxics 2022, 10, 797
Correction: Lenarczyk et al. T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys. Toxics 2022, 10, 797 Open
In the original publication [...]
View article: Myocardial Contractility Pattern Characterization in Radiation-Induced Cardiotoxicity Using Magnetic Resonance Imaging: A Pilot Study with ContractiX
Myocardial Contractility Pattern Characterization in Radiation-Induced Cardiotoxicity Using Magnetic Resonance Imaging: A Pilot Study with ContractiX Open
Radiation therapy (RT) plays an integral role in treating thoracic cancers, despite the risk of radiation-induced cardiotoxicity. We hypothesize that our newly developed magnetic resonance imaging (MRI)-based contractility index (Contracti…
View article: T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys
T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys Open
Heart disease is a significant adverse event caused by radiotherapy for some cancers. Identifying the origins of radiogenic heart disease will allow therapies to be developed. Previous studies showed non-targeted effects manifest as fibros…
View article: Effects of 5-Ion Beam Irradiation and Hindlimb Unloading on Metabolic Pathways in Plasma and Brain of Behaviorally Tested WAG/Rij Rats
Effects of 5-Ion Beam Irradiation and Hindlimb Unloading on Metabolic Pathways in Plasma and Brain of Behaviorally Tested WAG/Rij Rats Open
A limitation of simulated space radiation studies is that radiation exposure is not the only environmental challenge astronauts face during missions. Therefore, we characterized behavioral and cognitive performance of male WAG/Rij rats 3 m…
View article: 165Ethnic differences in type 2 diabetes mortality and hospitalisation rates in a New Zealand population1994-2018
165Ethnic differences in type 2 diabetes mortality and hospitalisation rates in a New Zealand population1994-2018 Open
Background Type 2 Diabetes (T2DM) affects different populations disproportionately including in New Zealand (NZ), where long-term temporal trends in cause-specific clinical outcomes between Māori, European and Pacific people remain unclear…
View article: Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit
Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit Open
A primary objective of the National Aeronautics and Space Administration (NASA) is expansion of humankind’s presence outside low-Earth orbit, culminating in permanent interplanetary travel and habitation. Having no inherent means of physio…
View article: Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune system
Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune system Open
Cardiac disease is a frequent and significant adverse event associated with radiotherapy for cancer. Identifying the underlying mechanism responsible for radiation injury to the heart will allow interventions to be developed. In the presen…
View article: Age at Exposure to Radiation Determines Severity of Renal and Cardiac Disease in Rats
Age at Exposure to Radiation Determines Severity of Renal and Cardiac Disease in Rats Open
Radiotherapy with sparsely ionizing photons is a cornerstone of successful cancer treatment. Age at time of exposure to radiation is known to influence biological outcomes for many end points. The effect of dose and age at exposure upon th…
View article: <i>Lactobacillus plantarum</i> 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease
<i>Lactobacillus plantarum</i> 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease Open
Rationale: A strong association has emerged between the gut microbiome and atherosclerotic disease. Our recent data suggest Lactobacillus plantarum 299v (Lp299v) supplementation reduces infarct size in male rats. Limited human data are ava…
View article: P.066 Cortical autonomic patterns in Neurogenic Orthostatic Hypotension
P.066 Cortical autonomic patterns in Neurogenic Orthostatic Hypotension Open
Background: Neurogenic orthostatic hypotension (NOH), defined as a drop in systolic blood pressure (SBP) ≥30mmHg on standing or head-up tilt, is associated with autonomic dysfunction. The cortical autonomic network (CAN) is a network of br…
View article: RECOMBINANT ERYTHROPOIETIN MITIGATES REPERFUSION INJURY IN NEONATAL RAT CARDIOMYOCYTES BY NOVEL MULTIPLE SIGNALLING PATHWAYS
RECOMBINANT ERYTHROPOIETIN MITIGATES REPERFUSION INJURY IN NEONATAL RAT CARDIOMYOCYTES BY NOVEL MULTIPLE SIGNALLING PATHWAYS Open
Objective: Recombinant Human Erythropoietin (rhEPO) is strongly inferred to protect the cardiomyocytes from the reperfusion injury and our aim is to elucidate the cardioprotective effect and the exact mechanism behind the cardioprotection.…
View article: Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats
Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats Open
Intestinal microbiota determine severity of myocardial infarction in rats. We determined whether low molecular weight metabolites derived from intestinal microbiota and transported to the systemic circulation are linked to severity of myoc…
View article: Pre-treatment of EPO maintains mitochondrial membrane potential in H/R induced H9C2 cells.
Pre-treatment of EPO maintains mitochondrial membrane potential in H/R induced H9C2 cells. Open
The effect of EPO on Membrane potential was determined by colocalization studies using Rhodamine-123 and DCFH-DA. H9C2 cells were subjected to H/R with or without pre-treatment with 20 U/ml EPO for 24 hrs. H9C2 cells pretreated with EPO an…
View article: Simvastatin mitigates increases in risk factors for and the occurrence of cardiac disease following 10 Gy total body irradiation
Simvastatin mitigates increases in risk factors for and the occurrence of cardiac disease following 10 Gy total body irradiation Open
The ability of simvastatin to mitigate the increases in risk factors for and the occurrence of cardiac disease after 10 Gy total body irradiation ( TBI ) was determined. This radiation dose is relevant to conditioning for stem cell transpl…
View article: 101 Applications for a Binary Table and a Spreadsheet
101 Applications for a Binary Table and a Spreadsheet Open
The purpose of this paper is to show how to create a binary table in Excel and to give applications of a varied nature using the binary table to generate data on which mathematical investigations can be based. Elementary applications consi…
View article: Conditional Formatting Revisited: a Companion for Teachers and Others
Conditional Formatting Revisited: a Companion for Teachers and Others Open
Conditional formatting is a truly remarkable feature of the modern spreadsheet program, exemplified by Microsoft Excel. In the decade since the first publication on conditional formatting in this journal, and with the singular exception of…
View article: Another 101 Uses for a Binary Table and a Spreadsheet
Another 101 Uses for a Binary Table and a Spreadsheet Open
The purpose of this paper is to broaden the scope of a previous paper and show applications of a varied nature using the binary table to generate data on which mathematical investigations can be based. Elementary applications considered ar…