John E. Dowling
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View article: Treatments for RYR1-related disorders
Treatments for RYR1-related disorders Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To analyse the benefits and harms of pharmacological or other interventions (e.g. special diet, exercise programme) compared with pla…
View article: High-throughput ultrastructural analysis of macular telangiectasia type 2
High-throughput ultrastructural analysis of macular telangiectasia type 2 Open
Introduction Macular Telangiectasia type 2 (MacTel), is an uncommon form of late-onset, slowly-progressive macular degeneration. Associated with regional Müller glial cell loss in the retina and the amino acid serine synthesized by Müller …
View article: Neuromodulation: Actions of Dopamine, Retinoic Acid, Nitric Oxide, and Other Substances on Retinal Horizontal Cells
Neuromodulation: Actions of Dopamine, Retinoic Acid, Nitric Oxide, and Other Substances on Retinal Horizontal Cells Open
Whereas excitation and inhibition of neurons are well understood, it is clear that neuromodulatory influences on neurons and their synapses play a major role in shaping neural activity in the brain. Memory and learning, emotional and other…
View article: Restoring partial vision to a blind patient
Restoring partial vision to a blind patient Open
This paper reports an important breakthrough in partially restoring sight to a man who had lost his vision due to retinitis pigmentosa (RP), a heritable retinal degenerative disease that affects approximately 1 in 4000 people. Long conside…
View article: Evaluation of preprocessing techniques for chief complaint classification
Evaluation of preprocessing techniques for chief complaint classification Open
OBJECTIVE: To determine whether preprocessing chief complaints before automatically classifying them into syndromic categories improves classification performance. METHODS: We preprocessed chief complaints using two preprocessors (CCP and …
View article: Rods Contribute to Visual Behavior in Larval Zebrafish
Rods Contribute to Visual Behavior in Larval Zebrafish Open
Because the nof mutants lacked a photopic ERG but displayed scotopic ERGs after dark adaptation, the mutants clearly had functional rods. WT larvae and the nof mutants displayed comparable scotopic light-On VMRs and scotopic OKRs after dar…
View article: A connectomics approach to understanding a retinal disease
A connectomics approach to understanding a retinal disease Open
Significance Macular degenerations of the retina are a leading cause of legal blindness (visual acuity less than 20/200) globally, and we know little about what causes them. Here we describe electron microscopic observations from the retin…
View article: Decision letter: Human foveal cone photoreceptor topography and its dependence on eye length
Decision letter: Human foveal cone photoreceptor topography and its dependence on eye length Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract We provide the first measures…
View article: Capturing Light—The Photoreceptors
Capturing Light—The Photoreceptors Open
The human eye contains two types of photoreceptors - rods that mediate dim-light vision, and three subtypes of cones that operate in bright light and are responsible for color vision. Light is captured in the photoreceptors by light- sensi…
View article: Higher-Level Processing and Visual Perception
Higher-Level Processing and Visual Perception Open
Cortical area V1 projects mainly to adjacent area V2 where stripe-like regions contain neurons mainly orientation-selective, movement-sensitive, or color-selective. From there, neurons project to separate areas concerned with form, movemen…
View article: Analyzing the Visual Image—The Retina
Analyzing the Visual Image—The Retina Open
Two stages of visual information processing occur in the retina–one in the outer retina and the other in the inner retina. The photoreceptors provide input to the outer retina whereas the bipolar cells carry the visual signals from the out…
View article: Beyond the Retina—Lateral Geniculate Nucleus and Visual Cortex
Beyond the Retina—Lateral Geniculate Nucleus and Visual Cortex Open
In mammals, most visual information is transmitted from the eye to area V1 of the cortex via the lateral geniculate nucleus, although some visual information goes to non-cortical structures. In V1 there is substantial processing of visual …