Explanipedia

Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway Open

Wisberty J. Gordián‐Vélez, Kevin D. Browne, Jonathan H. Galarraga, Dimple Chouhan, John E. Duda , et al. · 2024

Parkinson's disease is characterized by motor deficits emerging from insufficient dopamine in the striatum after degeneration of dopaminergic neurons and their long‐projecting axons comprising the nigrostriatal pathway. To address this, a …

Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology Open

Gábor G. Kovács, Lea T. Grinberg, Glenda M. Halliday, Irina Alafuzoff, Brittany N. Dugger , et al. · 2024

UNDERSTANDING SYNUCLEINOPATHY IN PARKINSON’S DISEASE USING A HUMAN TISSUE ENGINEERED NIGROSTRIATAL PATHWAY Open

Dimple Chouhan, Saarang Karandikar, Franco A. Laimo, Ronit Patel, Kevin D. Browne , et al. · 2023

Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs–An exploratory study Open

James P. Harris, Constance J. Mietus, Kevin D. Browne, Kathryn L. Wofford, Carolyn E. Keating , et al. · 2023

Closed-head traumatic brain injury (TBI) is induced by rapid motion of the head, resulting in diffuse strain fields throughout the brain. The injury mechanism(s), loading thresholds, and neuroanatomical distribution of affected cells remai…

Persistence of Hyper-Ramified Microglia in Porcine Cortical Gray Matter after Mild Traumatic Brain Injury Open

Michael R. Grovola, Alan Jinich, Nicholas Paleologos, Edgardo J. Arroyo, Kevin D. Browne , et al. · 2023

Traumatic brain injury (TBI) is a major contributor to morbidity and mortality in the United States as several million people visit the emergency department every year due to TBI exposures. Unfortunately, there is still no consensus on the…

Axonal Tract Reconstruction Using a Tissue-Engineered Nigrostriatal Pathway in a Rat Model of Parkinson’s Disease Open

Laura A. Struzyna, Kevin D. Browne, Justin C. Burrell, Wisberty J. Gordián Vélez, Kathryn L. Wofford , et al. · 2022

Parkinson’s disease (PD) affects 1–2% of people over 65, causing significant morbidity across a progressive disease course. The classic PD motor deficits are caused by the degeneration of dopaminergic neurons in the substantia nigra pars c…

Understanding health care needs among Veterans with Parkinson's disease: A survey study Open

Megan Feeney, John E. Duda, Amie Hiller, Jay I. Phillips, Christiana Evers , et al. · 2022

Among Veterans, it is estimated that 110,000 are living with Parkinson's disease (PD) in the United States. Whether or not Veterans living with PD are enrolled in the Veterans Health Administration (VHA), they may require special considera…

Non-tremor motor dysfunction in Lewy body dementias is associated with AD biomarkers Open

Ian M. Walker, Katheryn A Q Cousins, Andrew Siderowf, John E. Duda, James F. Morley , et al. · 2022

Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced Parkinsonism Open

Whitley W. Aamodt, Jacob G. Dubroff, Gang Cheng, Betty Taylor, Stephanie A. Wood , et al. · 2022

Drug-induced parkinsonism (DIP) can be clinically indistinguishable from degenerative parkinsonism, and bedside assessments are needed to differentiate between these conditions. We examined 34 U.S. Veterans with DIP using 123 I-FP-CIT (DAT…

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium Open

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy , et al. · 2022

The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy body dementia (LBD), which includes dementia with Lewy bodies (DL…

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium Open

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy , et al. · 2021

The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy Body Dementia (LBD), which includes Dementia with Lewy Bodies (DL…

Uremic Striatopallidal Syndrome Manifesting as Acute Onset Chorea Open

Emily K. Forbes, Pavan A. Vaswani, John E. Duda, James F. Morley · 2021

Renal dysfunction has been associated with a spectrum of movement disorders, including parkinsonism, tremor, myoclonus, ataxia, and chorea.1 Here, we present a case of an African-American man with chronic kidney disease who developed uremi…

Commentary: Uremic Striatopallidal Syndrome Manifesting as Acute Onset Chorea Open

Anthony E. Lang, Emily K. Forbes, Pavan A. Vaswani, John E. Duda, James F. Morley , et al. · 2021

This is the case of a 50-year-old African American male with diabetes, hypertension, and chronic kidney disease attributed to membranous nephropathy stable under treatment with peritoneal dialysis.1 He presented acutely with generalized ch…

Restoring lost nigrostriatal fibers in Parkinson’s disease based on clinically-inspired design criteria Open

Wisberty J. Gordián‐Vélez, Dimple Chouhan, Rodrigo A. España, H. Isaac Chen, Jason A. Burdick , et al. · 2021

Dopaminergic axon tracts within a hyaluronic acid hydrogel encasement for implantation to restore the nigrostriatal pathway Open

Wisberty J. Gordián‐Vélez, Kevin D. Browne, Jonathan H. Galarraga, John E. Duda, Rodrigo A. España , et al. · 2021

Parkinson’s disease (PD) affects 10 million patients worldwide, making it the second most prevalent neurodegenerative disease. Motor symptoms emerge from the loss of dopamine in the striatum after the death of dopaminergic neurons and the …

Diverse changes in microglia morphology and axonal pathology during the course of 1 year after mild traumatic brain injury in pigs Open

Michael R. Grovola, Nicholas Paleologos, Daniel P. Brown, Nathan Tran, Kathryn L. Wofford , et al. · 2021

Over 2.8 million people experience mild traumatic brain injury (TBI) in the United States each year, which may lead to long‐term neurological dysfunction. The mechanical forces that are caused by TBI propagate through the brain to produce …

Cognitive Profile and Markers of Alzheimer Disease–Type Pathology in Patients With Lewy Body Dementias Open

Erica Howard, David J. Irwin, Katya Rascovsky, Naomi Nevler, Sanjana Shellikeri , et al. · 2021

Markers of AD-type copathology are implicated in impaired language performance in LBD. Biologically based classification of LBD may be advantageous over clinically defined syndromes to elucidate clinical heterogeneity.

Tau pathology associates with in vivo cortical thinning in Lewy body disorders Open

Nicola Spotorno, David G. Coughlin, Christopher A. Olm, David A. Wolk, Sanjeev Vaishnavi , et al. · 2020

Objectives To investigate the impact of Alzheimer’s disease (AD) co‐pathology on an in vivo structural measure of neurodegeneration in Lewy body disorders (LBD). Methods We studied 72 LBD patients (Parkinson disease (PD) = 2, PD‐MCI = 25, …

Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in Pigs Open

Michael R. Grovola, Nicholas Paleologos, Daniel P. Brown, Nathan Tran, Kathryn L. Wofford , et al. · 2020

Over 2.8 million people experience mild traumatic brain injury (TBI) in the United States each year, which may lead to long-term neurological dysfunction. The mechanical forces that occur due to TBI propagate through the brain to produce d…

Hippocampal subfield pathologic burden in Lewy body diseases <i>vs</i>. Alzheimer’s disease Open

David G. Coughlin, Ranjit Ittyerah, Claire Peterson, Jennifer S. Phillips, Stephanie Miller , et al. · 2020

Aims Lewy body diseases (LBD) are characterized by alpha‐synuclein (SYN) pathology, but comorbid Alzheimer’s disease (AD) pathology is common and the relationship between these pathologies in microanatomic hippocampal subfields is understu…

A Review of the Relationship Between Vitamin D and Parkinson Disease Symptoms Open

Michelle Fullard, John E. Duda · 2020

Vitamin D is a fat-soluble secosteroid that exerts its effects by binding to the vitamin D receptor (VDR), through which it directly and indirectly modulates the expression of hundreds to thousands of genes. While originally known for its …

Neurons in Subcortical Oculomotor Regions Are Vulnerable to Plasma Membrane Damage after Repetitive Diffuse Traumatic Brain Injury in Swine Open

Carolyn E. Keating, Kevin D. Browne, John E. Duda, D. Kacy Cullen · 2020

Oculomotor deficits, such as insufficiencies in accommodation, convergence, and saccades, are common following traumatic brain injury (TBI). Previous studies in patients with mild TBI attributed these deficits to insufficient activation of…

Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse traumatic brain injury in pigs Open

Michael R. Grovola, Nicholas Paleologos, Kathryn L. Wofford, James P. Harris, Kevin D. Browne , et al. · 2020

Emerging regenerative medicine and tissue engineering strategies for Parkinson’s disease Open

James P. Harris, Justin C. Burrell, Laura A. Struzyna, H. Isaac Chen, Mijail D. Serruya , et al. · 2020

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, affecting 1–2% of people over 65. The classic motor symptoms of PD result from selective degeneration of dopaminergic neurons in the substantia nigra…

Excessive daytime sleepiness and topographic expansion of Lewy pathology Open

Robert D. Abbott, G. Webster Ross, John E. Duda, Chol Shin, Jane Uyehara‐Lock , et al. · 2019

The association between EDS and PD includes relationships with extensive topographic LP expansion. The neocortex could be especially vulnerable to adverse relationships between sleep disorders and aggregation of misfolded α-synuclein and L…

Early and Accurate Identification of Parkinson Disease Among US Veterans Open

Sneha Mantri, John E. Duda, James F. Morley · 2019

Early and accurate identification and management of veterans at risk for Parkinson disease is an important priority area for the US Department of Veterans Affairs because of the substantial impact on quality of life and disability-adjusted…

Most cases with Lewy pathology in a population-based cohort adhere to the Braak progression pattern but ‘failure to fit’ is highly dependent on staging system applied Open

David G. Coughlin, Helen Petrovitch, Lon R. White, Joseph V. Noorigian, Kamal Masaki , et al. · 2019

Lewy Body Dementia Association’s Research Centers of Excellence Program: Inaugural Meeting Proceedings Open

Bethany L. Peterson, Melissa J. Armstrong, Douglas Galasko, James E. Galvin, Jennifer G. Goldman , et al. · 2019

The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator's meeting was held on December 14, 2017, in New Orleans. The program was established to increase patient access to clinical experts on Lewy …

Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology Open

G. Webster Ross, Robert D. Abbott, Helen Petrovitch, John E. Duda, Caroline M. Tanner , et al. · 2018

Background Organochlorine pesticides are associated with an increased risk of Parkinson's disease. A preliminary analysis from the Honolulu‐Asia Aging Study suggested that heptachlor epoxide, a metabolite from an organochlorine pesticide e…

Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders Open

David G. Coughlin, Sharon X. Xie, Mendy Liang, Andrew Williams, Claire Peterson , et al. · 2018

Objective To use digital histology in a large autopsy cohort of Lewy body disorder (LBD) patients with dementia to test the hypotheses that co‐occurring Alzheimer disease (AD) pathology impacts the anatomic distribution of α‐synuclein (SYN…

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