John E. Ellis
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View article: Allosteric modulators of M1 muscarinic receptors enhance acetylcholine efficacy and decrease locomotor activity and turning behaviors in zebrafish
Allosteric modulators of M1 muscarinic receptors enhance acetylcholine efficacy and decrease locomotor activity and turning behaviors in zebrafish Open
Allosteric modulation of muscarinic acetylcholine receptors (mAChR) has been identified as a potential strategy for regulating cholinergic signaling in the treatment of various neurological disorders. Most positive allosteric modulators (P…
View article: 0452 C-reactive Protein Is Associated with Hypertension in Mild-to-Moderate Obstructive Sleep Apnea: Age Effect
0452 C-reactive Protein Is Associated with Hypertension in Mild-to-Moderate Obstructive Sleep Apnea: Age Effect Open
Introduction Mild-to-moderate obstructive sleep apnea (mmOSA) is highly prevalent in general population. It has been shown that mmOSA is a significant risk factor for the development of cardiovascular and cerebrovascular disease in young a…
View article: Hybrid Allosteric Modulators of M1 Muscarinic Receptors Enhance Acetylcholine Efficacy and Decrease Locomotor Activity and Turning Behaviors in Zebrafish
Hybrid Allosteric Modulators of M1 Muscarinic Receptors Enhance Acetylcholine Efficacy and Decrease Locomotor Activity and Turning Behaviors in Zebrafish Open
Allosteric modulation of muscarinic acetylcholine receptors (mAChR) has been identified as a potential strategy for regulating cholinergic signaling in the treatment of various neurological disorders. Most positive allosteric modulators (P…
View article: Crystal structure and synthesis of the bis(anthracene)dicuprate dianion as the dipotassium salt, [K(tetrahydrofuran)<sub>2</sub>]<sub>2</sub>[{Cu(9,10-η<sup>2</sup>-anthracene)}<sub>2</sub>], the first anionic arene complex of copper
Crystal structure and synthesis of the bis(anthracene)dicuprate dianion as the dipotassium salt, [K(tetrahydrofuran)<sub>2</sub>]<sub>2</sub>[{Cu(9,10-η<sup>2</sup>-anthracene)}<sub>2</sub>], the first anionic arene complex of copper Open
Reactions of (tricyclohexylphosphane)copper(I) chloride with two equivalents of potassium anthracene (KAn) in tetrahydrofuran (THF) at 200 K provides air-sensitive but thermally stable (at 293 K) solutions from which yellow crystalline blo…
View article: CCDC 1176158: Experimental Crystal Structure Determination
CCDC 1176158: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Effect of Spin–Orbit Coupling on Phonon-Mediated Magnetic Relaxation in a Series of Zero-Valent Vanadium, Niobium, and Tantalum Isocyanide Complexes
Effect of Spin–Orbit Coupling on Phonon-Mediated Magnetic Relaxation in a Series of Zero-Valent Vanadium, Niobium, and Tantalum Isocyanide Complexes Open
Spin-vibronic coupling leads to spin relaxation in paramagnetic molecules, and an understanding of factors that contribute to this phenomenon is essential for designing next-generation spintronics technology, including single-molecule magn…
View article: Allostery of atypical modulators at oligomeric G protein-coupled receptors
Allostery of atypical modulators at oligomeric G protein-coupled receptors Open
Many G protein-coupled receptors (GPCRs) are therapeutic targets, with most drugs acting at the orthosteric site. Some GPCRs also possess allosteric sites, which have become a focus of drug discovery. In the M 2 muscarinic receptor, allost…
View article: Correction: The Chatt reaction: conventional routes to homoleptic arenemetalates of d-block elements
Correction: The Chatt reaction: conventional routes to homoleptic arenemetalates of d-block elements Open
Correction for ‘The Chatt reaction: conventional routes to homoleptic arenemetalates of d-block elements’ by John E. Ellis et al., Dalton Trans., 2019, 48, 9538–9563.
View article: STERICALLY CROWDED σ‐ AND π‐BONDED METAL ARYL COMPLEXES
STERICALLY CROWDED σ‐ AND π‐BONDED METAL ARYL COMPLEXES Open
Homoleptic complexes in which alkyl or aryl groups are η1-bound to a transition metal form one of the cornerstones of organometallic chemistry. For example, most transition metals form both neutral and anionic complexes with σ-bonding aryl…
View article: CCDC 1843316: Experimental Crystal Structure Determination
CCDC 1843316: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1551212: Experimental Crystal Structure Determination
CCDC 1551212: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1551214: Experimental Crystal Structure Determination
CCDC 1551214: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1551213: Experimental Crystal Structure Determination
CCDC 1551213: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Allosteric modulation in monomers and oligomers of a G protein-coupled receptor
Allosteric modulation in monomers and oligomers of a G protein-coupled receptor Open
The M2 muscarinic receptor is the prototypic model of allostery in GPCRs, yet the molecular and the supramolecular determinants of such effects are unknown. Monomers and oligomers of the M2 muscarinic receptor therefore have been compared …
View article: Author response: Allosteric modulation in monomers and oligomers of a G protein-coupled receptor
Author response: Allosteric modulation in monomers and oligomers of a G protein-coupled receptor Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1: Extended Methods Appendix 2: Extended Details of the Molecular Modeling and Dynamics References Decision letter Author respons…
View article: Crystal structure of heptakis(2,6-dimethylphenyl isocyanide-κ<i>C</i>)vanadium(I) iodide
Crystal structure of heptakis(2,6-dimethylphenyl isocyanide-κ<i>C</i>)vanadium(I) iodide Open
The title salt, [V(C 9 H 9 N) 7 ] + I − or [V(CNXyl) 7 ] + I − (Xyl is 2,6-dimethylphenyl), crystallized from tetrahydrofuran at low temperatures after reacting (Et 4 N) + [V(CO) 6 ] − , excess of CNXyl and iodine. The complex cation and t…
View article: Crystal structure of (18-crown-6)potassium(I) [(1,2,3,4,5-η)-cycloheptadienyl][(1,2,3-η)-cycloheptatrienyl]cobalt(I)
Crystal structure of (18-crown-6)potassium(I) [(1,2,3,4,5-η)-cycloheptadienyl][(1,2,3-η)-cycloheptatrienyl]cobalt(I) Open
The reaction of bis(anthracene)cobaltate(−I) with excess cycloheptatriene, C 7 H 8 , resulted in a new 18-electron cobaltate containing two different seven-membered ring ligands, based on single-crystal X-ray diffraction. The asymmetric un…